Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Separation of Blood Leucocytes, Granulocytes and Lymphocytes

1974 • 667 citations

Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

1998 • 524 citations

Primary progressive multiple sclerosis

1997 • 505 citations

Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination

1998 • 423 citations

Differential Ultrastructural Localization of Myelin Basic Protein, Myelin/Oligodendroglial Glycoprotein, and 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase in the CNS of Adult Rats

1989 • 388 citations

Randomised placebo-controlled trial of monthly intravenous immunoglobulin therapy in relapsing-remitting multiple sclerosis

1997 • 386 citations

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

1994 • 384 citations

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

1997 • 365 citations

Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study

1999 • 345 citations

Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone

1997 • 320 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

1995 • 314 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation

1999 • 289 citations

Animal models

1994 • 276 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Multiple sclerosis: Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown

1981 • 259 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

1998 • 257 citations

Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily

1992 • 240 citations

The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat

1995 • 231 citations

Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)

1987 • 217 citations

Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls

1991 • 196 citations

Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system.

1997 • 190 citations

Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.

1995 • 185 citations

Neuropathology in multiple sclerosis: new concepts

1998 • 177 citations

Neuropathology in multiple sclerosis: new concepts

1998 • 172 citations

Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions

1997 • 169 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

Autoimmune Pathogenesis of Multiple Sclerosis: Role of Autoreactive T Lymphocytes and New Immunotherapeutic Strategies

1997 • 159 citations

Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)‐derived peptide: Preliminary analysis of MOG T cell epitopes

1995 • 157 citations

The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane.

1986 • 151 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis

1992 • 117 citations

Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis

1998 • 116 citations

Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG)

1999 • 114 citations

[31] Myelin basic proteins

1974 • 111 citations

Multiple Sclerosis: Lessons from Neuropathology

1998 • 107 citations

TCR usage in human and experimental demyelinating disease

1996 • 104 citations

Creation of a model for multiple sclerosis in Callithrix jacchus marmosets

1997 • 86 citations

Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis

1997 • 80 citations

Investigation of Myelin/Oligodendrocyte Glycoprotein Membrane Topology

1996 • 77 citations

T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects

1998 • 63 citations

Multiple sclerosis: comparison of the human T-cell response to S100 beta and myelin basic protein reveals parallels to rat experimental autoimmune panencephalitis

1997 • 56 citations

HPRT mutant T-cell lines from multiple sclerosis patients recognize myelin proteolipid protein peptides

1997 • 47 citations

Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region

1995 • 44 citations

TCR repertoire to proteolipid protein (PLP) in multiple sclerosis (MS): homologies between PLP-specific T cells and MS-associated T cells in TCR junctional sequences

1996 • 23 citations

Conjugal multiple sclerosis

1992 • 19 citations

Nucleotide sequences of H2 g7 K and D loci of nonobese diabetic mice

1995 • 9 citations