Effects of Muscarinic Agonists and Depolarizing Agents on Inositol Monophosphate Accumulation in the Rabbit Vagus Nerve

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Simplex Method for Function Minimization

1965 • 27,535 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

Fitting curves to data using nonlinear regression: a practical and nonmathematical review

1987 • 1,314 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

Molecular Properties of the Muscarinic Acetylcholine Receptor

1987 • 478 citations

Selectivity of muscarinic antagonists in radioligand and in vivo experiments for the putative M1, M2 and M3 receptors.

1987 • 442 citations

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat

1986 • 373 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

1986 • 283 citations

Muscarinic receptor subclasses

1983 • 238 citations

Intracellular Ca2+ activates phospholipase C

1988 • 233 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Agonists differentiate muscarinic receptors that inhibit cyclic AMP formation from those that stimulate phosphoinositide metabolism.

1984 • 219 citations

Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase.

1985 • 217 citations

Inositol lipids in cell signalling.

1989 • 212 citations

Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms

1984 • 194 citations

Muscarinic agonist binding and phospholipid turnover in brain.

1983 • 185 citations

Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: II. Calcium Requirement

1984 • 182 citations

Characterization of the cholinergic stimulation of phosphoinositide hydrolysis in rat brain slices

1984 • 175 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine.

1987 • 157 citations

Effects of divalent and trivalent cations on Na+-Ca2+ exchange in cardiac sarcolemmal vesicles

1983 • 155 citations

Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: stimulatory effects of agents that enhance influx of sodium ions.

1986 • 151 citations

Polyphosphoinositides in myelin

1965 • 136 citations

Differential Stimulation of Inositol Phospholipid Turnover in Brain by Analogs of Oxotremorine

1984 • 134 citations

Human platelets contain phospholipase C that hydrolyzes polyphosphoinositides.

1983 • 129 citations

The selectivity of ion channels in nerve and muscle

1982 • 128 citations

New subtypes of muscarinic acetylcholine receptors.

1989 • 126 citations

Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1

1989 • 123 citations

Electrically induced release of acetylcholine from denervated Schwann cells

1974 • 118 citations

A high-performance liquid chromatographic method to measure 32P incorporation into phosphorylated metabolites in cultured cells

1982 • 113 citations

Dihydropyridine calcium channel activators and antagonists influence depolarization-evoked inositol phospholipid hydrolysis in brain

1985 • 112 citations

The action of acetylcholine and some related substances on conduction in mammalian non‐myelinated nerve fibres

1961 • 106 citations

Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.

1987 • 105 citations

Muscarinic Receptors and Hydrolysis of Inositol Phospholipids in Rat Cerebral Cortex and Parotid Gland

1985 • 100 citations

The Cholinergic Receptor Protein in Its Membrane Environment

1975 • 93 citations

The putative M1 muscarinic receptor does not regulate phosphoinositide hydrolysis. Studies with pirenzepine and McN-A343 in chick heart and astrocytoma cells.

1985 • 92 citations

Tetradotoxin-sensitive and tetrodotoxin-resistant Na+ channels differ in their sensitivity to Cd2+ and Zn2+

1986 • 88 citations

Ca2+ transport in nerve fibers

1988 • 83 citations

The control by Ca2+ of the polyphosphoinositide phosphodiesterase and the Ca2+-pump ATPase in human erythrocytes

1982 • 80 citations

A Putative M₃ Muscarinic Cholinergic Receptor of High Molecular Weight Couples to Phosphoinositide Hydrolysis in Human SK‐N‐SH Neuroblastoma Cells

1988 • 78 citations

Axonal transport of muscarinic cholinergic receptors in rat vagus nerve: high and low affinity agonist receptors move in opposite directions and differ in nucleotide sensitivity

1982 • 77 citations

Depolarization of nonmyelinated fibers of the rat vagus nerve produced by activation of protein kinase C

1988 • 73 citations

Formation of inositol phosphates in synaptoneurosomes of guinea pig brain: stimulatory effects of receptor agonists, sodium channel agents and sodium and calcium ionophores

1988 • 71 citations

Potassium Ion Facilitation of Phosphoinositide Turnover Activation by Muscarinic Receptor Agonists in Rat Brain

1986 • 64 citations

Stimulation of phosphoinositide breakdown in brain synaptoneurosomes by agents that activate sodium influx: antagonism by tetrodotoxin, saxitoxin, and cadmium.

1987 • 61 citations

Membrane depolarization and carbamoylcholine stimulate phosphatidylinositol turnover in intact nerve terminals.

1988 • 58 citations

Phosphoinositide hydrolysis induced by depolarization and sodium channel activation in mouse cerebrocortical slices

1989 • 58 citations

Neurotransmitter‐Induced Inositol Phosphate Formation in Neurons in Primary Culture

1988 • 57 citations

Progesterone derivatives that bind to the digitalis receptor

1989 • 57 citations

On the involvement of multiple muscarinic receptor subtypes in the activation of phosphoinositide metabolism in rat cerebral cortex.

1990 • 56 citations

Regional characterization of agonist and depolarization-induced phosphoinositide hydrolysis in rat brain.

1986 • 55 citations

Depolarisation of guinea-pig visceral smooth muscle causes hydrolysis of inositol phospholipids

1986 • 51 citations

Raising the ambient potassium ion concentration enhances carbachol stimulated phosphoinositide hydrolysis in rat brain hippocampal and cerebral cortical miniprisms

1986 • 51 citations

Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells: effect of sodium channel activators.

1988 • 50 citations

Dual pathways in muscarinic receptor stimulation of phosphoinositide hydrolysis

1987 • 48 citations

Evidence that transmitter can be released from regions of the nerve cell other than presynaptic axon terminal: Axonal release of acetylcholine without modulation

1983 • 47 citations

Stimulation of phosphoinositide hydrolysis in myelin by muscarinic agonist and potassium

1987 • 46 citations

Phosphatidic Acid and Phosphoinositide Turnover in Myelin and Its Stimulation by Acetylcholine

1988 • 45 citations

[Axon-Schwann cell relations].

1972 • 45 citations

Assessment of mechanistic proposals for the binding of agonists to cardiac muscarinic receptors

1986 • 44 citations

Depolarization increases inositolphosphate production in a particulate preparation from rat brain

1986 • 44 citations

Accumulation of inositol phosphates in sympathetic ganglia. Effects of depolarization and of amine and peptide neurotransmitters

1985 • 44 citations

Increased Intracellular Calcium Stimulates ³H‐Inositol Polyphosphate Accumulation in Rat Cerebral Cortical Slices

1990 • 43 citations

M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells

1991 • 38 citations

Depolarisation-evoked release of acetylcholine can mediate phosphoinositide hydrolysis in slices of rat cerebral cortex

1987 • 37 citations

Effects of Neuronal Activity on Inositol Phospholipid Metabolism in the Rat Autonomic Nervous System

1985 • 36 citations

Axon-Schwann Cell Relationship

1984 • 36 citations

Selective effector coupling of muscarinic acetylcholine receptor subtypes.

1989 • 35 citations

Effects of surugatoxin and other nicotinic and muscarinic antagonists on phosphatidylinositol metabolism in active sympathetic ganglia

1977 • 34 citations

THE USE OF DRUG ANTAGONISTS FOR THE IDENTIFICATION AND CLASSIFICATION OF DRUGS

1947 • 34 citations

Muscarinic Cholinergic Receptor‐Mediated Phosphoinositide Metabolism in Peripheral Nerve

1991 • 32 citations

Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: constitutional and stereochemical aspects

1991 • 31 citations

Presence of cholinergic neurons in the vagal afferent system: Biochemical and immunohistochemical approaches

1989 • 31 citations

Muscarinic Cholinergic Receptors and their Interactions with Drugs

1989 • 30 citations

Kinetic Analysis of A23187‐Mediated Polyphosphoinositide Breakdown in Rat Cortical Synaptosomes Suggests that Inositol Bisphosphate Does Not Arise Primarily by Degradation of Inositol Trisphosphate

1989 • 30 citations

Selective effector coupling of muscarinic acetylcholine receptor subtypes

1989 • 27 citations

The human astrocytoma cell line 1321 N1 contains M₂‐glandular type muscarinic receptors linked to phosphoinositide turnover

1989 • 27 citations

Depolarization-induced changes in the muscarinic receptor in rat brain and heart are mediated by pertussis-toxin-sensitive G-proteins

1991 • 27 citations

Muscarine stimulates the hydrolysis of inositol-containing phospholipids in the superior cervical ganglion.

1985 • 26 citations

Muscarinic receptor coupling to inositol phospholipid metabolism in guinea-pig cerebral cortex, parotid gland and ileal smooth muscle

1988 • 25 citations

Stereospecific regulation of [3H]inositol monophosphate accumulation by calcium channel drugs from all three main chemical classes

1986 • 24 citations

Functional and direct binding studies using subtype selective muscarinic receptor antagonists

1988 • 23 citations

Dual Effects of K+ Depoiarisation on Inositol Polyphosphate Production in Rat Cerebral Cortex

1989 • 23 citations

Relationship of ATP Turnover, Polyphosphoinositide Metabolism, and Protein Phosphorylation in Sciatic Nerve and Derived Peripheral Myelin Subfractions from Normal and Streptozotocin Diabetic Rats

1989 • 23 citations

Rapid accumulation and sustained turnover of inositol phosphates in cerebral-cortex slices after muscarinic-receptor stimulation

1989 • 23 citations

Lowering of the extracellular Na+ concentration enhances high-K+-induced formation of inositol phosphates in the guinea-pig ileum

1988 • 21 citations

Differences between muscarinic-receptor- and Ca2+-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices

1990 • 20 citations

After potentials in nonmyelinated nerve fibers

1991 • 19 citations

Comparison of norepinephrine- and veratrine-induced phosphoinositide hydrolysis in rat brain.

1987 • 15 citations

Phospholipids in the Nervous System, Vol. 1

1984 • 13 citations

Effect of Electrical Stimulation on Phosphoinositide Metabolism in Rat Sciatic Nerve In Vivo

1985 • 11 citations

Biochemical measurement of muscarinic receptor efficacy and its role in receptor regulation.

1988 • 11 citations

EFFECT OF β‐ADRENERGIC DRUGS ON ADENOSINE 3′,5′‐MONOPHOSPHATE IN RABBIT VAGUS NERVE

1977 • 10 citations

Neurochemical and behavioural effects of muscarinic acetylcholine receptor agonists.

1988 • 7 citations

Cholinergic inositol phosphate formation in striatal neurons is mediated by distinct mechanisms

1991 • 6 citations

Prostaglandins cause cyclic AMP accumulation in peripheral nerve

1979 • 5 citations

Cholinergic regulation of impulse frequency in peripheral nerve

1987 • 1 citations