M3 muscarinic cholinoceptors are linked to phosphoinositide metabolism in rat cerebellar granule cells

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

The cerebellum and neural control

1985 • 1,686 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400

1989 • 1,039 citations

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

1988 • 792 citations

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

1987 • 766 citations

The role of depolarization in the survival and differentiation of cerebellar granule cells in culture

1987 • 764 citations

Putative receptor for inositol 1,4,5-trisphosphate similar to ryanodine receptor

1989 • 531 citations

The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells

1986 • 431 citations

Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat

1986 • 373 citations

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence

1986 • 344 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Muscarinic receptor subclasses

1983 • 238 citations

Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase.

1985 • 217 citations

Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes

1983 • 197 citations

Survival, morphology and adhesion properties of cerebellar interneurones cultured in chemically defined and serum-supplemented medium

1985 • 157 citations

Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay

1990 • 150 citations

Inositol polyphosphates and neuronal calcium homeostasis

1988 • 133 citations

Neurotransmitter Receptors and Phosphoinositide Turnover

1989 • 133 citations

Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1

1989 • 123 citations

Dihydropyridine calcium channel activators and antagonists influence depolarization-evoked inositol phospholipid hydrolysis in brain

1985 • 112 citations

Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells

1985 • 110 citations

Differential receptor occupancy requirements for muscarinic cholinergic stimulation of inositol lipid hydrolysis in brain and in neuroblastomas.

1987 • 105 citations

Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle

1990 • 97 citations

Stereospecific recognition sites for [3H]inositol(1,4,5)-trisphosphate in particulate preparations of rat cerebellum

1987 • 87 citations

A Putative M₃ Muscarinic Cholinergic Receptor of High Molecular Weight Couples to Phosphoinositide Hydrolysis in Human SK‐N‐SH Neuroblastoma Cells

1988 • 78 citations

Effects of thyroid state on brain development: Muscarinic acetylcholine and GABA receptors

1980 • 77 citations

Muscarinic acetylcholine receptor-mediated phosphoinositide turnover in cultured cerebellar granule cells: desensitization by receptor agonists.

1987 • 73 citations

Pirenzepine indicates heterogeneity of muscarinic receptors linked to cerebral inositol phospholipid metabolism

1985 • 63 citations

Regional characterization of agonist and depolarization-induced phosphoinositide hydrolysis in rat brain.

1986 • 55 citations

Serotonergic, adrenergic and histaminergic receptors coupled to phospholipase C in cultured cerebellar granule cells of rats

1987 • 45 citations

Increased Intracellular Calcium Stimulates ³H‐Inositol Polyphosphate Accumulation in Rat Cerebral Cortical Slices

1990 • 43 citations

Ontogeny of muscarinic receptors in the rat brain with emphasis on the differentiation of M1- and M2-subtypes— semi-quantitative in vitro autoradiography

1987 • 38 citations

Depolarisation-evoked release of acetylcholine can mediate phosphoinositide hydrolysis in slices of rat cerebral cortex

1987 • 37 citations

Is Inositol Bisphosphate the Product of A23187 and Carbachol‐Mediated Polyphosphoinositide Breakdown in Synaptosomes?

1988 • 34 citations

Transmembrane signalling; intracellular messengers and implications for drug development

1991 • 33 citations

Dual Effects of K+ Depoiarisation on Inositol Polyphosphate Production in Rat Cerebral Cortex

1989 • 23 citations

[³H]N‐Methylscopolamine Binding Studies Reveal M₂ and M₃ Muscarinic Receptor Subtypes on Cerebellar Granule Cells in Primary Culture

1990 • 21 citations

Differences between muscarinic-receptor- and Ca2+-induced inositol polyphosphate isomer accumulation in rat cerebral-cortex slices

1990 • 20 citations

MOLECULAR PHARMACOLOGY OF CLONED MUSCARINIC RECEPTORS

1990 • 10 citations

Profile of phosphatidylinositol metabolism stimulated by carbachol and glutamate in primary cultures of rat cerebellar neurons

1989 • 8 citations

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