The Interferon (IFN)-stimulated Gene Sp100 Promoter Contains an IFN-γ Activation Site and an Imperfect IFN-stimulated Response Element Which Mediate Type I IFN Inducibility

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.

1982 • 1,367 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

1994 • 1,043 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 • 798 citations

Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells

1994 • 668 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.

1995 • 531 citations

The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion.

1994 • 492 citations

Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro.

1989 • 484 citations

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element.

1987 • 398 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Autoantibodies to the Nuclear Sp100 Protein in Primary Biliary Cirrhosis and Associated Diseases: Epitope Specificity and Immunoglobulin Class Distribution

1992 • 365 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either.

1990 • 332 citations

Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0)

1993 • 316 citations

PML, a growth suppressor disrupted in acute promyelocytic leukemia.

1994 • 296 citations

Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons.

1991 • 278 citations

Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis.

1990 • 266 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

1995 • 261 citations

The PML growth-suppressor has an altered expression in human oncogenesis.

1995 • 241 citations

The acute promyelocytic leukaemia-associated PML gene is induced by interferon.

1995 • 228 citations

Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site.

1990 • 228 citations

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3.

1990 • 220 citations

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

1989 • 218 citations

PML nuclear bodies are general targets for inflammation and cell proliferation.

1995 • 163 citations

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

1994 • 162 citations

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein.

1989 • 159 citations

IFN enhance expression of Sp100, an autoantigen in primary biliary cirrhosis.

1992 • 155 citations

Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment.

1995 • 154 citations

Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.

1991 • 132 citations

Interferon‐Modulated Expression of Genes Encoding the Nuclear‐Dot‐Associated Proteins Sp100 and Promyelocytic Leukemia Protein (PML)

1996 • 122 citations

Two Nuclear Dot‐Associated Proteins, PML and SplOO, are Often Co‐Autoimmunogenic in Patients with Primary Biliary Cirrhosis

1995 • 121 citations

Alpha Interferon and Gamma Interferon Stimulate Transcription of a Single Gene through Different Signal Transduction Pathways

1989 • 112 citations

Autoimmune sera recognize a 100 kD nuclear protein antigen (sp-100).

1987 • 105 citations

PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.

1995 • 97 citations

Disruption of PML-associated nuclear bodies during human cytomegalovirus infection

1995 • 96 citations

Adenovirus Infection Induces Rearrangements in the Intranuclear Distribution of the Nuclear Body-Associated PML Protein

1995 • 91 citations

Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene.

1986 • 85 citations

Nuclear Dot Antigens may Specify Transcriptional Domains in the Nucleus

1993 • 84 citations

Cytokines and Growth factors signal through tyrosine phosphorylation of a family of related transcription factors

1994 • 84 citations

Transcription factors induced by interferons α and γ

1990 • 80 citations

Plasmid vectors with multiple cloning sites and cat-reporter gene for promoter cloning and analysis in animal cells

1988 • 58 citations

Generation of a Variant T(2;8) Translocation of Burkitt's Lymphoma by Site-Specific Recombination via the Kappa Light-Chain Joining Signals

1987 • 48 citations

The interferon‐stimulable response elements of two human genes detect overlapping sets of transcription factors

1993 • 42 citations

Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes

1994 • 34 citations

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.

1994 • 33 citations

Interferon Therapy of Multiple Sclerosis

1997 • 28 citations

Interferon response pathways—a paradigm for cytokine signalling?

1994 • 26 citations

A Highly Amplified Mouse Gene Is Homologous to the Human Interferon-Responsive Sp100 Gene Encoding an Autoantigen Associated with Nuclear Dots

1996 • 24 citations

A Member of the Mouse LRR Transcript Family with Homology to the Human Sp100 Gene

2004 • 15 citations

Functional differences in the promoters of the interferon‐inducible (2′‐5′)A oligoadenylate synthetase and 6–16 genes in interferon‐resistant Daudi cells

1994 • 14 citations

Two short autoepitopes on the nuclear dot antigen are similar to epitopes encoded by the Epstein-Barr virus.

1995 • 12 citations