Molecular genetics of murine lupus

Murine Models of Systemic Lupus Erythematosus

1985 • 1,572 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice.

1978 • 637 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Somatic recombination in a murine T-cell receptor gene

1984 • 468 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

Mouse T cell antigen receptor: Structure and organization of constant and joining gene segments encoding the β polypeptide

1984 • 407 citations

Structure, organization, and somatic rearrangement of T cell gamma genes

1985 • 395 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

1984 • 377 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

Murine T-cell receptor mutants with deletions of beta-chain variable region genes.

1986 • 304 citations

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 • 303 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor

1984 • 290 citations

The murine T-cell receptor uses a limited repertoire of expressed Vβ gene segments

1985 • 283 citations

Rationale for bone marrow transplantation in the treatment of autoimmune diseases.

1985 • 244 citations

Structure, expression and divergence of T-cell receptor β-chain variable regions

1984 • 237 citations

Diversity and structure of genes of the α family of mouse T-cell antigen receptor

1985 • 228 citations

Unusual organization and diversity of T-cell receptor a-chain genes

1985 • 212 citations

Genomic organization of the genes encoding mouse T-cell receptor α-chain

1985 • 202 citations

Rearrangement of T-cell receptor beta-chain genes during T-cell development.

1985 • 200 citations

T-Cell Receptor β-Chain Expression: Dependence on Relatively Few Variable Region Genes

1985 • 197 citations

Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

1983 • 188 citations

Limited diversity of the rearranged T-cell γ gene

1985 • 185 citations

Rearrangement and transcription of the β-chain genes of the T-cell antigen receptor in different types of murine lymphocytes

1985 • 172 citations

Induction of murine autoimmune disease by chronic polyclonal B cell activation.

1983 • 171 citations

Splenic immunoglobulin-secreting cells and their regulation in autoimmune mice.

1980 • 166 citations

Localization of a T-cell receptor diversity-region element

1984 • 159 citations

(NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction.

1981 • 157 citations

THE EFFECT OF INDUCED CHRONIC VIRAL INFECTIONS ON THE IMMUNOLOGIC DISEASES OF NEW ZEALAND MICE

1970 • 148 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Changes in immunoglobulin class and subclass of anti-DNA antibodies with increasing age in N/ZBW F1 hybrid mice.

1976 • 146 citations

Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice.

1977 • 145 citations

Molecular Genetics of the T Cell-Receptor Beta Chain

1985 • 140 citations

Variability and repertoire size of T-cell receptor Vα gene segments

1985 • 131 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

Transplantation of Autoimmune Potential. I. Development of Antinuclear Antibodies in H-2 Histocompatible Recipients of Bone Marrow from New Zealand Black Mice

1974 • 122 citations

B cell dependence on and response to accessory signals in murine lupus strains.

1983 • 108 citations

A Large Deletion Within the T-Cell Receptor Beta-Chain Gene Complex in New Zealand White Mice

1985 • 105 citations

Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells.

1980 • 100 citations

Monoclonal antibodies to DNA and RNA from NZB/NZW F1 mice: antigenic specificities and NH2 terminal amino acid sequences.

1984 • 98 citations

Genetic elements used for a murine lupus anti-DNA autoantibody are closely related to those for antibodies to exogenous antigens.

1985 • 97 citations

Clonal diversity and T-cell receptor beta-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice.

1986 • 96 citations

Segregation of polymorphic T-cell receptor genes in human families.

1985 • 94 citations

Autoimmunity and Increased c-mybTranscription

1984 • 89 citations

The influence of the lpr gene on B cell activation: Differential antibody expression in lpr congenic mouse strains

1984 • 81 citations

The lymphoproliferating cells of MRL‐lpr/lpr mice are a polyclonal population that bear the T lymphocyte receptor for antigen

1985 • 80 citations

Isotypes of spontaneous and mitogen-induced autoantibodies in SLE-prone mice.

1984 • 79 citations

Vβ gene polymorphism and a major polyclonal T cell receptor idiotype

1985 • 75 citations

Expression of autoimmunity by marrow

1978 • 70 citations

Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.

1986 • 68 citations

Cellular basis of in vitro anti-DNA antibody production: evidence for T cell dependence of IgG-class anti-DNA antibody synthesis in the (NZB X NZW)F1 hybrid.

1986 • 68 citations

Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators.

1985 • 65 citations

Ig heavy chain variable region gene complex of lupus mice exhibits normal restriction fragment length polymorphism.

1985 • 58 citations

Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes.

1983 • 53 citations

Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor.

1985 • 37 citations

B-cell hyperactivity in murine lupus I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells

1983 • 34 citations

Proton Magnetic Resonance Spectrum of Polywater

1970 • 33 citations

B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone mice

1983 • 28 citations

Specificities of NZB anti-H-2d CML reactions: role of Qa-1 and retroviral gp70 antigens.

1981 • 13 citations