DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling

DNA Repair and Mutagenesis

2006 • 4,725 citations

Requirement of mammalian DNA polymerase-β in base-excision repair

1996 • 820 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/orgadd45 Genes

2000 • 422 citations

Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis.

1996 • 337 citations

A role for p53 in base excision repair

2001 • 332 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.

2000 • 246 citations

Cisplatin induces a persistent activation of JNK that is related to cell death

1998 • 233 citations

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

2001 • 222 citations

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases

1999 • 194 citations

Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

1997 • 190 citations

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

1999 • 134 citations

Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells

2000 • 128 citations

O6-alkylguanine DNA lesions trigger apoptosis

1998 • 128 citations

Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation

2002 • 119 citations

Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1

2004 • 119 citations

DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

2001 • 117 citations

Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

2001 • 109 citations

Specific Binding of Human MSH2·MSH6 Mismatch-Repair Protein Heterodimers to DNA Incorporating Thymine- or Uracil-containing UV Light Photoproducts Opposite Mismatched Bases

1999 • 102 citations

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

1997 • 95 citations

Cell Proliferation and DNA Breaks Are Involved in Ultraviolet Light-induced Apoptosis in Nucleotide Excision Repair-deficient Chinese Hamster Cells

2002 • 82 citations

A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs.

1997 • 77 citations

c-Fos is involved in the cellular defence against the genotoxic effect of UV radiation

1995 • 74 citations

Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling

2002 • 70 citations

Chromosomal aberrations induced by restriction endonucleases

1985 • 63 citations

Human Topoisomerase IIα and IIβ Interact with the C-Terminal Region of p53

2000 • 60 citations

Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis

2000 • 59 citations

Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both

2001 • 57 citations

Comparison of the genotoxic and apoptosis-inducing properties of ganciclovir and penciclovir in Chinese hamster ovary cells transfected with the thymidine kinase gene of herpes simplex virus-1: Implications for gene therapeutic approaches

2000 • 56 citations

Induction of c-fos, c-jun, junB and junD mRNA and AP-1 by alkylating mutagens in cells deficient and proficient for the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability.

1996 • 49 citations

Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir

2002 • 48 citations

Critical steps in alkylation-induced aberration formation

1998 • 45 citations

DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage.

2001 • 39 citations

Deficiency in DNA polymerase beta provokes replication-dependent apoptosis via DNA breakage, Bcl-2 decline and caspase-3/9 activation.

2002 • 37 citations

Mismatch binding proteins and tolerance to alkylating agents in human cells

1990 • 29 citations

Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug β-D-glucosyl-ifosfamide mustard

2002 • 27 citations

Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair

2001 • 27 citations

Repair of O6-methylguanine is not affected by thymine base pairing and the presence of MMR proteins

2001 • 26 citations

Apoptosis Induced by (E)-5-(2-Bromovinyl)-2′-deoxyuridine in Varicella Zoster Virus Thymidine Kinase-Expressing Cells Is Driven by Activation of c-Jun/Activator Protein-1 and Fas Ligand/Caspase-8

2003 • 15 citations

Cloning and Functional Analysis of cDNA Encoding the Hamster Bcl-2 Protein

2000 • 4 citations