Cisplatin-induced apoptosis in 43-3B and 27-1 cells defective in nucleotide excision repair

Caspases: Enemies Within

1998 • 6,923 citations

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

1995 • 5,208 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria

1998 • 932 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Cisplatin and DNA repair in cancer chemotherapy

1995 • 506 citations

Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis

1996 • 442 citations

Protein Complexes Activate Distinct Caspase Cascades in Death Receptor and Stress-Induced Apoptosis

2000 • 332 citations

Molecular cloning of a human DNA repair gene

1984 • 307 citations

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours

1999 • 295 citations

Anticancer Drugs Induce Caspase-8/FLICE Activation and Apoptosis in the Absence of CD95 Receptor/Ligand Interaction

1999 • 294 citations

Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent.

2000 • 246 citations

Association between the level of ERCC-1 expression and the repair of cisplatin-induced DNA damage in human ovarian cancer cells.

2000 • 158 citations

BCL-2 expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells.

1995 • 144 citations

ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells

2000 • 143 citations

The role of apoptosis in cell killing by cisplatin: a flow cytometric study

1994 • 141 citations

Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents

1996 • 131 citations

Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

1998 • 124 citations

Molecular cloning and biological characterization of the human excision repair gene ERCC-3.

1990 • 119 citations

DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

2001 • 117 citations

Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells

2000 • 112 citations

Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation

2001 • 109 citations

Proteins that specifically recognize cisplatin‐damaged DNA: a clue to anticancer activity of cisplatin

1998 • 99 citations

Cisplatin sensitivity/resistance in UV repair-deficient Chinese hamster ovary cells of complementation groups 1 and 3

1993 • 99 citations

Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.

2000 • 85 citations

Radiation-induced Apoptosis and Necrosis in Molt-4 Cells: A Study of Dose-effect Relationships and Their Modification

1993 • 84 citations

Inhibition of RNA Polymerase II Transcription in Human Cell Extracts by Cisplatin DNA Damage

1999 • 75 citations

Cloning and characterization of Chinese hamster p53 cDNA

1997 • 72 citations

Intracellular IL-1beta is an inhibitor of Fas-mediated apoptosis.

1996 • 67 citations

Interstrand Cross-Links Induce DNA Synthesis in Damaged and Undamaged Plasmids in Mammalian Cell Extracts

1999 • 66 citations

Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage

1994 • 60 citations

Identification of a Silencer, Enhancer, and Basal Promoter Region in the Human CD95 (Fas/APO-1) Gene

1995 • 57 citations

Cisplatin inhibits chromatin remodeling, transcription factor binding, and transcription from the mouse mammary tumor virus promoter in vivo.

1995 • 55 citations

Anticancer Drugs Induce Caspase-8/FLICE Activation and Apoptosis in the Absence of CD95 Receptor/Ligand Interaction

1999 • 48 citations

Inhibition of Homodimerization of Poly(ADP-ribose) Polymerase by Its C-terminal Cleavage Products Produced during Apoptosis

2000 • 38 citations

Differential processing of UV mimetic and interstrand crosslink damage by XPF cell extracts

2000 • 26 citations

Regulation of Apoptosis Reduction in the Cisplatin-Resistant A431 Cell Line by Bcl-2 and CPP32

1999 • 23 citations

Ionizing radiation and the activation of caspase-8 in highly apoptosis-sensitive lymphoma cells

1999 • 23 citations

The Requirement of Yeast Ssl2 (Rad25) for the Repair of Cisplatin-Damaged DNA

1998 • 6 citations