Deficiency in DNA polymerase beta provokes replication-dependent apoptosis via DNA breakage, Bcl-2 decline and caspase-3/9 activation.

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A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

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Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

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DNA Repair and Mutagenesis

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DNA EXCISION REPAIR

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p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

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Requirement of mammalian DNA polymerase-β in base-excision repair

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MTT colorimetric assay for testing macrophage cytotoxic activity in vitro

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The comet assay: mechanisms and technical considerations

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Radiation-induced apoptosis: Relevance to radiotherapy

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Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

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The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells.

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Mammalian Abasic Site Base Excision Repair

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Base excision repair of DNA in mammalian cells

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The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

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Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

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Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway

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Molecular mechanisms involved in the production of chromosomal aberrations

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Ultraviolet Radiation-induced Apoptosis Is Mediated by Activation of CD-95 (Fas/APO-1)

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Different DNA Polymerases Are Involved in the Short- and Long-Patch Base Excision Repair in Mammalian Cells

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Transfection and expression of human O⁶-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

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Chromosomal instability, reproductive cell death and apoptosis induced by O6-methylguanine in Mex−, Mex+ and methylation-tolerant mismatch repair compromised cells: facts and models

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Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines

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DNA double-strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation

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Protection against Methylation-induced Cytotoxicity by DNA Polymerase β-Dependent Long Patch Base Excision Repair

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Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.

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O6-alkylguanine DNA lesions trigger apoptosis

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DNA double-strand breaks trigger apoptosis in p53-deficient fibroblasts

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Susceptibility to drug-induced apoptosis correlates with differential modulation of Bad, Bcl-2 and Bcl-xL protein levels

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Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

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A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs.

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DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide

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Identification of Apoptotic and Necrotic Human Leukemic Cells by Flow Cytometry

1994 • 50 citations

Critical steps in alkylation-induced aberration formation

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