The origin of CD4−CD8−TCRαβ+ thymocytes: a model based on T-cell receptor avidity

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction

1991 • 523 citations

The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo

1994 • 291 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes.

1987 • 230 citations

Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells.

1993 • 165 citations

Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes.

1994 • 155 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

An unusual lineage of alpha/beta T cells that contains autoreactive cells.

1991 • 152 citations

Phenotype, ontogeny, and repertoire of CD4-CD8- T cell receptor alpha beta + thymocytes. Variable influence of self-antigens on T cell receptor V beta usage.

1991 • 107 citations

Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice.

1991 • 97 citations

Positive selection of invariant V alpha 14+ T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells.

1995 • 84 citations

CD2-CD4-CD8- lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2+CD4+CD8+ thymic precursor.

1993 • 82 citations

Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin.

1995 • 79 citations

Induction of interleukin 2 receptor beta chain expression by self-recognition in the thymus.

1994 • 68 citations

Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.

1994 • 64 citations

Distinctive selection mechanisms govern the T cell receptor repertoire of peripheral CD4-CD8- alpha/beta T cells.

1992 • 43 citations

T cell receptor V_β genes expressed by IgG anti‐DNA autoantibody‐inducing T cells in lupus nephritis: Forbidden receptors and double‐negative T cells

1990 • 39 citations

Role of TCR specificity in CD4 versus CD8 lineage commitment.

1995 • 39 citations

Cultured Lyt-2- L3T4- T lymphocytes from normal thymus or lpr mice express a broad spectrum of cytolytic activity.

1986 • 29 citations

A novel form of self tolerance dictated in the thymus of transgenic mice with autoreactive TCR α and β chain genes

1994 • 15 citations

The balance between deletion and activation of CD4⁺8⁺ thymocytes is controlled by T cell receptor‐antigen interactions and is affected by cyclosporin A

1994 • 11 citations