Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Two populations of Ia-like molecules on a human B cell line.

1980 • 1,112 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Peptides Naturally Presented by MHC Class I Molecules

1993 • 803 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Emerging Principles for the Recognition of Peptide Antigens by MHC Class I Molecules

1992 • 730 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation

1991 • 687 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle

1992 • 414 citations

Detection of a novel human class II HLA antigen

1983 • 387 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Production of human cells expressing individual transferred HLA-A,-B,-C genes using an HLA-A,-B,-C null human cell line.

1989 • 305 citations

The HLA-A,B "negative" mutant cell line C1R expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon.

1992 • 290 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.

1991 • 242 citations

Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

1992 • 234 citations

Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells.

1988 • 226 citations

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries.

1992 • 224 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens.

1985 • 183 citations

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak.

1992 • 174 citations

Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.

1991 • 159 citations

Nomenclature for factors of the HLA system, 1991

1992 • 148 citations

In vitro peptide binding to soluble empty class I major histocompatibility complex molecules isolated from transfected Drosophila melanogaster cells.

1992 • 134 citations

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86

1993 • 107 citations

Dipeptidyl Peptidase IV in the Immune System. Effects of Specific Enzyme Inhibitors on Activity of Dipeptidyl Peptidase IV and Proliferation of Human Lymphocytes

1991 • 107 citations

Self-peptide released from class II HLA-DR1 exhibits a hydrophobic two-residue contact motif.

1992 • 85 citations

Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis

1993 • 72 citations

Conformational and structural characteristics of peptides binding to HLA-DR molecules.

1991 • 62 citations

Nomenclature for factors of theHLA system, 1991

1992 • 50 citations

Membrane-bound peptidases of lymphocytes: functional implications.

1991 • 50 citations

Immunochemically purified DR antigens in liposomes stimulate xenogeneic cytolytic T cells in secondary in vitro cultures

1986 • 50 citations

The transport of class I major histocompatibility complex antigens is determined by sequences in the ?1 and ?2 protein domains

1990 • 43 citations

Structural analysis of class II major histocompatibility complex proteins.

1992 • 26 citations

Structural requirements for the interaction between class II MHC molecules and peptide antigens

1990 • 15 citations