GTP-binding proteins and their regulatory actions on ion channels.

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart

1983 • 471 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.

1986 • 424 citations

Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current

1982 • 421 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Calcium channel currents and their inhibition by (‐)‐baclofen in rat sensory neurones: modulation by guanine nucleotides.

1987 • 342 citations

Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms

1988 • 339 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons.

1986 • 313 citations

Mechanisms of signal transduction at the dopamine D2 receptor

1989 • 312 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.

1983 • 304 citations

Arachidonic acid metabolites as intracellular modulators of the G protein-gated cardiac K+ channel

1989 • 299 citations

Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.

1979 • 288 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Identification of receptor contact site involved in receptor–G protein coupling

1987 • 249 citations

A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.

1986 • 243 citations

Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons.

1988 • 242 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

Splice Variants of the α Subunit of the G Protein G _s Activate Both Adenylyl Cyclase and Calcium Channels

1989 • 225 citations

Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.

1982 • 221 citations

Common α2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices

1987 • 202 citations

ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.

1984 • 189 citations

Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.

1986 • 169 citations

A single GTP-binding protein regulates K+-channels coupled with dopamine, histamine and acetylcholine receptors

1987 • 161 citations

Activation of a G protein promotes agonist responses to calcium channel ligands

1987 • 160 citations

Relationships within the family of GTP-binding proteins isolated from bovine central nervous system.

1985 • 160 citations

Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.

1986 • 158 citations

Somatostatin induces an inward rectification in rat locus coeruleus neurones through a pertussis toxin‐sensitive mechanism.

1988 • 157 citations

cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones

1986 • 154 citations

Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.

1984 • 144 citations

Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.

1988 • 141 citations

Control of voltage‐dependent Ca ²⁺ channels by G protein‐coupled receptors

1988 • 126 citations

Involvement of a GTP-binding protein in mediation of serotonin and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA

1986 • 116 citations

Inositol 1,4,5‐trisphosphate and diacylglycerol mimic bradykinin effects on mouse neuroblastoma x rat glioma hybrid cells.

1988 • 114 citations

A Monoclonal Antibody to the α Subunit of G _k Blocks Muscarinic Activation of Atrial K ⁺ Channels

1988 • 85 citations

Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane

1986 • 77 citations

Up- and down-modulation of single K+ channel function by distinct second messengers

1988 • 70 citations

Neuronal muscarinic responses: role of protein kinase C

1988 • 55 citations

Receptor‐phosphoinositidase C coupling Multiple G‐proteins?

1987 • 54 citations

G Proteins: A Family of Signal Transducers

1986 • 54 citations

Cyclic GMP Cascade of Vision

1986 • 54 citations

Modulations of voltage-dependent ion channels by extracellular signals

1987 • 42 citations

Requirement of GTP on somatostatin-induced K+ current in human pituitary tumor cells.

1988 • 33 citations

Guanosine 5'‐triphosphate analogue activates potassium current modulated by neurotransmitters in Aplysia neurones.

1988 • 33 citations

Dopamine‐induced depolarizing responses associated with negative slope conductance in LB‐cluster neurones of Aplysia.

1988 • 29 citations

Control of ion conductances by muscarinic receptors.

1988 • 28 citations

Functional reconstitution of skeletal muscle Ca2+ channels: separation of regulatory and channel components.

1988 • 28 citations

Enzymatic model for receptor activation of GTP-binding regulatory proteins

1987 • 23 citations

G proteins in Aplysia: biochemical characterization and regional and subcellular distribution

1989 • 16 citations

Temperature-sensitive activation of G-protein regulating the resting membrane conductance of Aplysia neurons.

1989 • 14 citations

Regulation of cGMP‐dependent conductance in cytoplasmic membrane of rod outer segments by transducin

1989 • 12 citations

Islet activating protein-sensitive guanosine triphosphate-binding protein regulates K+-channels coupled with FMRFamide receptors.

1987 • 11 citations

Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase

1985 • 6 citations