Efficient Inhibition of RET/Papillary Thyroid Carcinoma Oncogenic Kinases by 4-Amino-5-(4-Chloro-Phenyl)-7-(t-Butyl)Pyrazolo[3,4-d]Pyrimidine (PP2)

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1996 • 1,055 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

1993 • 652 citations

The RET proto-oncogene in human cancers

2000 • 295 citations

The RET receptor: function in development and dysfunction in congenital malformation

2001 • 286 citations

Receptor tyrosine kinases as targets for anticancer drugs

2002 • 251 citations

One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes

1987 • 244 citations

Multiple endocrine neoplasia type 2 and RET: from neoplasia to neurogenesis

2000 • 236 citations

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

1996 • 199 citations

The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro.

1996 • 141 citations

The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.

2002 • 133 citations

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

1996 • 112 citations

The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome.

1999 • 108 citations

cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line

1990 • 105 citations

The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.

1997 • 90 citations

Tyrosines 1015 and 1062 Arein VivoAutophosphorylation Sites in Ret and Ret-Derived Oncoproteins¹

2000 • 60 citations

Perspective: Lessons Learned from Molecular Genetic Studies of Thyroid Cancer—Insights into Pathogenesis and Tumor-Specific Therapeutic Targets

2002 • 59 citations

Disabling Abl—Perspectives on Abl kinase regulation and cancer therapeutics

2002 • 52 citations

Ret-mediated mitogenesis requires Src kinase activity.

1999 • 49 citations

Establishment of a non‐tumorigenic papillary thyroid cell line (FB‐2) carrying the RET/PTC1 rearrangement

2001 • 42 citations

On the offensive

2002 • 33 citations