The Exocrine Pancreas: The Role of Secretagogues, Cyclic Nucleotides, and Calcium in Enzyme Secretion

Relationships between calcium and cyclic nucleotides in cell activation.

1977 • 849 citations

The constitution and properties of two gastrins extracted from hog antral mucosa: Part I The isolation of two gastrins from hog antral mucosa

1964 • 846 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

The timing of calcium action during neuromuscular transmission

1967 • 564 citations

Cyclic 3',5'-Nucleotide Phosphodiesterase

1971 • 531 citations

Stimulus—secretion coupling in a neurosecretory organ: the role of calcium in the release of vasopressin from the neurohypophysis

1964 • 475 citations

The interaction of cyclic nucleotides and calcium in the control of cellular activity.

1975 • 451 citations

Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini

1978 • 380 citations

Adenyl Cyclase in Cardiac Tissue

1970 • 304 citations

Commentary on ‘Effects of acetylcholine on the turnover of phosphoryl units in individuals phospholipids of pancreas slices and brain cortex slices’ by L.E. Hokin and M.R. Hokin Biochim. Biophys. Acta 18 (1955) 102–110

1989 • 282 citations

SYNTHESIS, INTRACELLULAR TRANSPORT AND DISCHARGE OF EXPORTABLE PROTEINS IN THE PANCREATIC ACINAR CELL AND OTHER CELLS

1978 • 279 citations

CYTOCHEMISTRY OF GOLGI FRACTIONS PREPARED FROM RAT LIVER

1974 • 263 citations

Adenyl Cyclase in Fat Cells

1970 • 235 citations

Action of ionophore A23187 at the cellular level. Separation of effects at the plasma and mitochondrial membranes.

1976 • 225 citations

Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Binding of radioiodinated peptide.

1976 • 214 citations

Interaction of porcine vasoactive intestinal peptide with dispersed pancreatic acinar cells from the guinea pig. Structural requirements for effects of vasoactive intestinal peptide and secretin on cellular adenosine 3':5'-monophosphate.

1976 • 200 citations

Ca++-dependent disassembly and reassembly of occluding junctions in guinea pig pancreatic acinar cells. Effect of drugs.

1978 • 197 citations

Isolation and structure of caerulein, an active decapeptide from the skin ofHyla caerulea

1967 • 194 citations

Regulation of amylase release from dispersed pancreatic acinar cells.

1977 • 192 citations

The Binding of Calcium at Lipid‐Water Interfaces

1967 • 182 citations

Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine

1979 • 181 citations

Effects of calcium omission on acetylcholine-stimulated amylase secretion and phospholipid synthesis in pigeon pancreas slices

1966 • 179 citations

Action of cholecystokinin and cholinergic agents on calcium transport in isolated pancreatic acinar cells.

1975 • 163 citations

Actions of derivatives of cyclic nucleotides on dispersed acini from guinea pig pancreas. Discovery of a competitive antagonist of the action of cholecystokinin.

1979 • 158 citations

Pancreatic acinar cells: the role of calcium in stimulus‐secretion coupling.

1976 • 155 citations

Role of adenine and guanine nucleotides in the activity and response of adenylate cyclase systems to hormones: evidence for multisite transition states.

1975 • 133 citations

Water and electrolyte secretion by the perfused pancreas of the cat

1968 • 129 citations

Dynamic changes of the luminal plasmalemma in stimulated parotid acinar cells. A freeze-fracture study.

1976 • 122 citations

Calcium ion uptake in isolated pancreas cells induced by secretagogues

1976 • 121 citations

Studies on the role of cyclic guanosine 3':5'-monophosphate and extracellular Ca2+ in the regulation of glycogenolysis in rat liver cells.

1976 • 119 citations

Protein kinases and protein kinase substrates.

1973 • 118 citations

Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. I. Use of chlorotetracycline as fluorescent probe.

1978 • 108 citations

Induction of Enzyme Secretion in Rat Pancreatic Slices Using the Ionophore A-23187 and Calcium

1974 • 106 citations

Control of pancreatic amylase release in vitro: effects of ions, cyclic AMP, and colchicine

1972 • 100 citations

The actions of pancreozymin in pancreas slices and the role of phospholipids in enzyme secretion

1956 • 97 citations

The potentiating influences of insulin on pancreozymin‐induced hyperpolarization and amylase release in the pancreatic acinar cell.

1976 • 95 citations

Secretion of hydrolases by perfused fragments of rat pancreas: effect of calcium

1971 • 95 citations

Hormone Receptor Complexes and Their Modulation of Membrane Function

1975 • 92 citations

Role of Ca2+ and cyclic AMP in protein secretion from rat exocrine pancreas

1972 • 89 citations

Cyclid 3':5'-nucleotide phosphodiesterase. Interconvertible multiple forms and their effects on enzyme activity and kinetics.

1976 • 86 citations

The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

1975 • 84 citations

Intracellular divalent cation release in pancreatic acinar cells during stimulus-secretion coupling. II. Subcellular localization of the fluorescent probe chlorotetracycline.

1978 • 83 citations

Cellular cyclic nucleotides and enzyme secretion in the pancreatic acinar cell.

1976 • 77 citations

Pancreatic acinar cells: acetylcholine‐evoked electrical uncoupling and its ionic dependency

1978 • 72 citations

Structural Difference between Luminal and Lateral Plasmalemma in Pancreatic Acinar Cells

1974 • 71 citations

THE ROLE OF CALCIUM IN PANCREATIC ACINAR CELL STIMULUS‐SECRETION COUPLING: AN ELECTROPHYSIOLOGICAL APPROACH*

1978 • 70 citations

Pancreatic acinar cells: localization of acetylcholine receptors and the importance of chloride and calcium for acetylcholine‐evoked depolarization

1977 • 70 citations

In vitro action of bombesin on amylase secretion, membrane potential, and membrane resistance in rat and mouse pancreatic acinar cells. A comparison with other secretagogues.

1978 • 68 citations

Distribution of cell surface saccharides on pancreatic cells. II. Lectin-labeling patterns on mature guinea pig and rat pancreatic cells.

1979 • 65 citations

Role of cyclic 3′,5t́-AMP in the action of physiological secretagogues on the metabolism of rat pancreas in vitro☆

1971 • 64 citations

Pancreatic acinar cells: the acetylcholine equilibrium potential and its ionic dependency

1977 • 64 citations

Insulin receptors in isolated mouse pancreatic acini

1978 • 62 citations

Cyclic nucleotide-dependent protein kinases of the rat pancreas

1973 • 60 citations

Pancreatic enzyme response to secretin and cholecystokinin‐pancreozymin in the rat

1973 • 58 citations

Intracellular messenger role of cyclic GMP in exocrine pancreas

1976 • 56 citations

Ca++ and pancreatic amylase release

1975 • 55 citations

Ca++ fluxes in isolated cells of rat pancreas. Effect of secretagogues and different Ca++ concentrations

1976 • 54 citations

Role of calcium in exocrine pancreatic secretion. II.Comparison of the effects of carbachol and the ionophore A-23187 on enzyme secretion and calcium movements in rabbit pancreas

1976 • 52 citations

Renal cortical adenyl cyclase: Effect of parathyroid hormone and calcium

1969 • 48 citations

The control of pancreatic secretion.

1972 • 45 citations

Actions of peptides isolated from amphibian skin on pancreatic acinar cells.

1978 • 44 citations

Separate activation sites for cholecystokinin and bombesin on pancreatic acini

1979 • 38 citations

Cyclic nucleotide-dependent protein kinase activity in acinar cells from guinea pig pancreas

1978 • 37 citations

The interaction of secretin with pancreatic membranes

1976 • 35 citations

The role of extracellular Ca2+ and cyclic nucleotides in the mechanism of enzyme secretion from the cat pancereas

1975 • 34 citations

Adenosine 3′,5′-monophosphate phosphodiesterase in rat pancreas

1973 • 34 citations

Action of cholera toxin on dispersed acini from guinea pig pancreas

1979 • 32 citations

Cholinergic and peptide-stimulated discharge of secretory protein in guinea pig pancreatic lobules. Role of intracellular and extracellular calcium.

1979 • 32 citations

The Interaction of Caerulein with the Rat Pancreas. 3. Structural Requirements for in vitro Binding of Caerulein-Like Peptides and Its Relationship to Increased Calcium Outflux, Adenylate Cyclase Activation, and Secretion

1978 • 32 citations

Effects of cholera toxin on cyclic adenosine 3′,5′-monophosphate concentration and secretory processes in the exocrine pancreas

1975 • 32 citations

Effect of lanthanum on 45Ca flux and secretion of protein from rat exocrine pancreas

1973 • 31 citations

The Interaction of Caerulein with the Rat Pancreas. 1. Specific Binding of [3H]Caerulein on Plasma Membranes and Evidence for Negative Cooperativity

1978 • 31 citations

Transport and Oxidation of Amino Acids and Glucose in the Isolated Exocrine Mouse Pancreas: Effects of Insulin and Pancreozymin

1974 • 31 citations

Calcium Metabolism and Enzyme Secretion in Guinea Pig Pancreas

1978 • 26 citations

Role of calcium in exocrine pancreatic secretion. IV. Calcium movements in isolated acinar cells of rabbit pancreas

1978 • 24 citations

“Phospholipid effect” and secretion in the rat pancreas

1972 • 21 citations

Guanosine 5′, α-β-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: Evidence against pyrophosphorylation mechanism

1977 • 20 citations

Rat pancreas adenylate cyclase

1979 • 19 citations

Effect of extracellular K+ concentration on resting potential, caerulein-induced depolarization and amylase release from mouse pancreatic acinar cells

1977 • 12 citations

The Distribution of Bivalent-Cation-Stimulated Adenosine Triphosphate Hydrolysis and Calcium Accumulation in Subcellular Fractions of Rat Pancreas

1975 • 6 citations

Catharanthine: A novel stimulator of pancreatic enzyme release

1978 • 6 citations

Deleted Work

1955 • 0 citations