DNA Methylation Differences Associated with Tumor Tissues Identified by Genome Scanning Analysis

Basic local alignment search tool

1990 • 87,358 citations

Statistical methods

1967 • 19,533 citations

Fingerprinting genomes using PCR with arbitrary primers

1990 • 5,327 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

1994 • 1,205 citations

The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

1991 • 904 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal

1993 • 602 citations

Imprinted expression of the Igf2r gene depends on an intronic CpG island

1997 • 578 citations

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

1989 • 540 citations

Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.

1994 • 481 citations

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

1991 • 467 citations

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1994 • 466 citations

DNA methylation errors and cancer.

1996 • 405 citations

Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines.

1998 • 376 citations

Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE)

1997 • 369 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines.

1998 • 207 citations

Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR.

1997 • 197 citations

Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure.

1996 • 165 citations

Identification of DNA methylation markers for human breast carcinomas using the methylation-sensitive restriction fingerprinting technique.

1997 • 123 citations

Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes.

1996 • 53 citations

Overexpression of DNA Methyltransferase in Myoblast Cells Accelerates Myotube Formation

1995 • 49 citations

Gene structure and transcription in mouse cells with extensively demethylated DNA.

1989 • 47 citations

Patterns of DNA methylation are indistinguishable in different individuals over a wide range of human DNA sequences

1991 • 42 citations

Overexpression of DNA Methyltransferase in Myoblast Cells Accelerates Myotube Formation

1995 • 41 citations

Patterns of DNA methylation in selected human genes in different Hodgkin's lymphoma and leukemia cell lines and in normal human lymphocytes.

1991 • 20 citations