Separate precursor cells for macrophages and microglia in mouse brain: immunophenotypic and immunoregulatory properties of the progeny

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

1990 • 1,897 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Turnover of resident microglia in the normal adult mouse brain

1992 • 679 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared.

1995 • 622 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Macrophages and the Nervous System

1991 • 429 citations

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

1992 • 395 citations

MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon

1987 • 346 citations

Mature microglia resemble immature antigen-presenting cells

1998 • 339 citations

Kinetics of Central Nervous System Microglial and Macrophage Engraftment: Analysis Using a Transgenic Bone Marrow Transplantation Model

1997 • 336 citations

Microglia are the major cell type expressing MHC class II in human white matter

1987 • 302 citations

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

1994 • 299 citations

Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury

1989 • 289 citations

Comparison of phenotypic and functional properties of immediately ex vivo and cultured human adult microglia

1996 • 217 citations

Effects of colony stimulating factors on isolated microglia in vitro

1990 • 216 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain.

1991 • 169 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Role of Lymphokine and Antigen in the Control of Specific T Cell Responses

1980 • 147 citations

Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras

1987 • 123 citations

Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents

1997 • 110 citations

Disparity in origin of mononuclear phagocyte populations.

1976 • 109 citations

Stromal macrophages of the choroid plexus situated at an interface between the brain and peripheral immune system constitutively express major histocompatibility class II antigens

1992 • 88 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4⁺and CD8⁺T‐cells

1998 • 78 citations

Ia antigens in the normal rat nervous system and in lesions of experimental allergic encephalomyelitis

1985 • 69 citations

Immunobiology of Microglial Cellsa

1988 • 64 citations

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with na�ve CD4+ and CD8+ T-cells

1998 • 60 citations

Biology of the mononuclear phagocyte system of the central nervous system and HIV infection

1994 • 48 citations

Cellular components of the immune barrier in the spinal meninges and dorsal root ganglia of the normal rat: immunohistochemical (MHC class II) and electron-microscopic observations

1993 • 40 citations

Origins of macrophage diversity: Functional and phenotypic analysis of cloned populations of mouse splenic macrophages

1987 • 37 citations

Some fixation reagents reduce or abolish the detectability of Ia-antigen and HLA-DR on cells

1984 • 37 citations

Human microglia activate lymphoproliferative responses to recall viral antigens

1996 • 31 citations

An oscillating bubble chamber for laboratory scale production of monoclonal antibodies as an alternative to ascitic tumours

1992 • 30 citations

HEL-Flu: an influenza virus containing the hen egg lysozyme epitope recognized by CD4+ T cells from mice transgenic for an alphabeta TCR.

1997 • 16 citations

Phenotypes and alloantigen-presenting activity of individual clones of microglia derived from the mouse brain

1992 • 16 citations

Mouse splenic macrophage cell lines with different antigen-presenting activities for CD4+ helper T cell subsets and allogeneic CD8+ T cells

1992 • 15 citations

Lessons from microglia in special sites.

1993 • 11 citations