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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

Data up to Jan 2025

Published2005
Citations425
References51

Total Citations Per Year

Abstract

References (51)

Cellular mechanisms of insulin resistance

2000 • 2,692 citations

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

1997 • 1,611 citations

Banting Lecture 2001

2002 • 1,445 citations

Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

1995 • 1,310 citations

Obesity Wars

2004 • 1,119 citations

Mechanisms of fatty acid-induced inhibition of glucose uptake.

1994 • 1,049 citations

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

2000 • 983 citations

A Family of Sulfonylurea Receptors Determines the Pharmacological Properties of ATP-Sensitive K+ Channels

1996 • 968 citations

Endogenous glucose production is inhibited by the adipose-derived protein Acrp30

2001 • 896 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

1992 • 664 citations

Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*

1999 • 650 citations

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

2002 • 640 citations

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

2003 • 523 citations

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis

2001 • 506 citations

Physiological and pathophysiological roles of ATP-sensitive K+ channels

2003 • 500 citations

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

1966 • 388 citations

A brain-liver circuit regulates glucose homeostasis

2005 • 377 citations

Overfeeding Rapidly Induces Leptin and Insulin Resistance

2001 • 353 citations

Leptin selectively decreases visceral adiposity and enhances insulin action.

1997 • 349 citations

Central melanocortin receptors regulate insulin action

2001 • 335 citations

Central melanocortin receptors regulate insulin action

2001 • 317 citations

Deconstructing Type 2 Diabetes

1999 • 312 citations

Control Mechanisms of Gluconeogenesis and Ketogenesis

1969 • 303 citations

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects

1999 • 298 citations

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.

1996 • 290 citations

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

2000 • 279 citations

Mechanisms of the free fatty acid-induced increase in hepatic glucose production

2003 • 273 citations

Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain

1998 • 261 citations

Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated

2004 • 181 citations

Effects of Free Fatty Acids on Gluconeogenesis and Autoregulation of Glucose Production in Type 2 Diabetes

2001 • 176 citations

The Role of Fatty Acids in Mediating the Effects of Peripheral Insulin on Hepatic Glucose Production in the Conscious Dog

1997 • 162 citations

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

2003 • 156 citations

Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites

2003 • 151 citations

Heterogeneity of Astrocyte Resting Membrane Potentials and Intercellular Coupling Revealed by Whole-Cell and Gramicidin-Perforated Patch Recordings from Cultured Neocortical and Hippocampal Slice Astrocytes

1997 • 145 citations

Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA

1998 • 138 citations

Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation

1991 • 124 citations

Selective effects of vagal deafferentation and celiac–superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients

2003 • 115 citations

Utilization of Plasma Fatty Acid in Rat Brain: Distribution of [14C]Palmitate Between Oxidative and Synthetic Pathways

1987 • 108 citations

A method for selective section of vagal afferent or efferent axons in the rat

1994 • 91 citations

Differential Interactions of Nateglinide and Repaglinide on the Human β-Cell Sulphonylurea Receptor 1

2002 • 88 citations

In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans

1991 • 86 citations

Evidence for a Unique Long Chain Acyl-CoA Ester Binding Site on the ATP-regulated Potassium Channel in Mouse Pancreatic Beta Cells

1997 • 83 citations

Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs

2002 • 72 citations

Important role of the hepatic vagus nerve in glucose uptake and production by the liver

2000 • 68 citations

The Hepatic Vagus Mediates Fat-Induced Inhibition of Diabetic Hyperphagia

2003 • 64 citations

Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes

2003 • 42 citations

Isolated Hepatic Cholinergic Denervation Impairs Glucose and Glycogen Metabolism

2000 • 42 citations

Intracellular Cl activity: evidence of dual mechanisms of cl absorption in sweat duct

1994 • 37 citations

Interrelations between ureogenesis and gluconeogenesis in isolated hepatocytes. The role of antion transport and the competition for energy

1978 • 31 citations

Effect of hepatic nerves on disposition of an intraduodenal glucose load

1993 • 22 citations

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