Role of Bim in the survival pathway induced by Raf in epithelial cells

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Targeting RAS signalling pathways in cancer therapy

2003 • 3,105 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

2002 • 695 citations

Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis

2001 • 620 citations

Activation of the ERK1/2 Signaling Pathway Promotes Phosphorylation and Proteasome-dependent Degradation of the BH3-only Protein, Bim

2003 • 607 citations

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

2003 • 531 citations

Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression

2000 • 439 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal

2002 • 368 citations

Identification of Novel Isoforms of the BH3 Domain Protein Bim Which Directly Activate Bax To Trigger Apoptosis

2002 • 287 citations

Analysis of the transcriptional program induced by Raf in epithelial cells

2001 • 255 citations

Activation of BAD by Therapeutic Inhibition of Epidermal Growth Factor Receptor and Transactivation by Insulin-like Growth Factor Receptor

2002 • 208 citations

Ubiquitin-mediated Degradation of the Proapoptotic Active Form of Bid

2000 • 195 citations

Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.

1995 • 195 citations

The p42/p44 MAP Kinase Pathway Prevents Apoptosis Induced by Anchorage and Serum Removal

2000 • 179 citations

Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation

2002 • 177 citations

Activation of ERK1/2 by ΔRaf-1 : ER* represses Bim expression independently of the JNK or PI3K pathways

2003 • 172 citations

Rapid Phosphorylation of Ets-2 Accompanies Mitogen-Activated Protein Kinase Activation and the Induction of Heparin-Binding Epidermal Growth Factor Gene Expression by Oncogenic Raf-1

1997 • 162 citations

Epidermal Growth Factor Receptor-dependent Control of Keratinocyte Survival and Bcl-xL Expression through a MEK-dependent Pathway

2001 • 151 citations

Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

2000 • 130 citations

BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

1998 • 128 citations

Proteasomes Modulate Balance Among Proapoptotic and Antiapoptotic Bcl-2 Family Members and Compromise Functioning of the Electron Transport Chain in Leukemic Cells

2001 • 122 citations

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase

2001 • 117 citations

Activation of the Bcl-2 promoter by nerve growth factor is mediated by the p42/p44 MAPK cascade

1999 • 104 citations

Adhesion-mediated signaling in the regulation of mammary epithelial cell survival.

1999 • 100 citations

Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

2000 • 99 citations

Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family¹

2001 • 91 citations