Specific GABAA circuits in brain development and therapy

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE

1963 • 2,565 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo

2003 • 1,312 citations

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

1997 • 1,223 citations

GABA_A‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

1995 • 1,219 citations

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

1999 • 1,154 citations

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

2000 • 933 citations

Molecular and Neuronal Substrate for the Selective Attenuation of Anxiety

2000 • 927 citations

Molecular and neuronal substrates for general anaesthetics

2004 • 750 citations

Tonically active GABAA receptors: modulating gain and maintaining the tone

2004 • 730 citations

A New Benzodiazepine Pharmacology

2002 • 706 citations

Inhibitory threshold for critical-period activation in primary visual cortex

2000 • 680 citations

Postnatal Neurodevelopmental Disorders: Meeting at the Synapse?

2003 • 671 citations

Interneuron Diversity series: Rhythm and mood in perisomatic inhibition

2003 • 630 citations

Pharmacological characterization of a novel cell line expressing human α₄β₃δ GABA_A receptors

2002 • 607 citations

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA_AReceptor

2002 • 604 citations

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

2004 • 559 citations

General anesthetic actionsin vivostrongly attenuated by a point mutation in the GABA_Areceptor β3 subunit

2002 • 555 citations

Trace fear conditioning involves hippocampal α ₅ GABA _A receptors

2002 • 510 citations

Specific GABA _A Circuits for Visual Cortical Plasticity

2004 • 467 citations

Ethanol enhances α ₄ β ₃ δ and α ₆ β ₃ δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans

2003 • 462 citations

Insensitivity to anaesthetic agents conferred by a class of GABAA receptor subunit

1997 • 402 citations

The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

1997 • 382 citations

Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons

2000 • 335 citations

Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications

2003 • 325 citations

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

2003 • 290 citations

Interneuron Diversity series: Fast in, fast out – temporal and spatial signal processing in hippocampal interneurons

2003 • 269 citations

Propofol and Other Intravenous Anesthetics Have Sites of Action on the γ-Aminobutyric Acid Type A Receptor Distinct from That for Isoflurane

1998 • 253 citations

Sedation and Anesthesia Mediated by Distinct GABA_AReceptor Isoforms

2003 • 247 citations

Diazepam-induced changes in sleep: Role of the α1 GABA_Areceptor subtype

2001 • 227 citations

Columnar Architecture Sculpted by GABA Circuits in Developing Cat Visual Cortex

2004 • 192 citations

Identification of a Novel, Selective GABA_Aα5 Receptor Inverse Agonist Which Enhances Cognition

2003 • 142 citations

Synaptic basis for developmental plasticity in somatosensory cortex

2004 • 137 citations

Molecular determinants for the action of general anesthetics at recombinant α₂β₃γ₂γ‐aminobutyric acid_A receptors

2001 • 136 citations

Modulation of rhythmic brain activity by diazepam: GABA _A receptor subtype and state specificity

2004 • 129 citations

The GABAA receptor gene family: new opportunities for drug development.

2003 • 112 citations

3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABA_A Receptor-Ion Channels

2002 • 107 citations

Activity-dependent organization of inhibitory circuits: lessons from the auditory system

2004 • 104 citations

Hippocampal α5 subunit-containing GABAA receptors modulate the expression of prepulse inhibition

2004 • 103 citations

Interneurons, Spike Timing, and Perception

2001 • 87 citations

Subunit‐selective modulation of GABA_A receptors by the non‐steroidal anti‐inflammatory agent, mefenamic acid

1999 • 73 citations

Residues in Transmembrane Domains I and II Determine γ-Aminobutyric Acid Type A_AReceptor Subtype-Selective Antagonism by Furosemide

1999 • 62 citations

Sleep and Its Modulation by Drugs That Affect GABAA Receptor Function

1999 • 57 citations

Mutational analysis of molecular requirements for the actions of general anaesthetics at the gamma-aminobutyric acidA receptor subtype, alpha1beta2gamma2.

2003 • 55 citations

Overexpression of the GABAA receptor ε subunit results in insensitivity to anaesthetics

2002 • 54 citations

Modifying quinolone antibiotics yields new anxiolytics

2003 • 47 citations

Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity

2003 • 41 citations

Selective GABAA circuits for novel CNS drugs

2004 • 13 citations