Treatment with clozapine and its effect on plasma homovanillic acid and norepinephrine concentrations in schizophrenia

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

Research Diagnostic Criteria

1978 • 6,988 citations

A Diagnostic Interview

1978 • 5,735 citations

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

1991 • 2,008 citations

Dopamine in schizophrenia: a review and reconceptualization

1991 • 1,963 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

1989 • 600 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients

1986 • 318 citations

The Risks and Benefits of Clozapine versus Chlorpromazine

1987 • 299 citations

A prospective study of clozapine in treatment-resistant schizophrenic patients

1989 • 269 citations

Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

1988 • 205 citations

Plasma catecholamine metabolites and early response to haloperidol.

1984 • 146 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

Neuroleptic affinities for human brain receptors and their use in predicting adverse effects.

1984 • 131 citations

In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: Implications for drug mechanisms of action

1986 • 128 citations

Antipsychotic Drug Action in Schizophrenic Patients: Effect on Cortical Dopamine Metabolism After Long-Term Treatment

1979 • 102 citations

Direct determination of homovanillic acid release from the human brain, and indicator of central dopaminergic activity

1991 • 91 citations

An example of European multicenter trials: multispectral analysis of clozapine.

1976 • 89 citations

Effects of Neuroleptic Treatment on Symptoms of Schizophrenia and Plasma Homovanillic Acid Concentrations

1991 • 79 citations

Dopamine Metabolism and Disposition in Schizophrenic Patients

1988 • 79 citations

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain

1984 • 74 citations

Plasma catecholamine metabolites in Schizophrenics: Evidence for the two-subtype concept

1990 • 70 citations

Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats

1984 • 69 citations

Serotonin function and treatment response to clozapine in schizophrenic patients

1993 • 68 citations

Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: Studies with chronic clozapine and haloperidol

1982 • 67 citations

Plasma and CSF HVA before and after pharmacological treatment

1989 • 60 citations

Control of exogenous factors affecting plasma homovanillic acid concentration

1987 • 60 citations

Changes in Plasma Homovanillic Acid Concentrations in Schizophrenic Patients Following Neuroleptic Discontinuation

1991 • 58 citations

Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients

1987 • 51 citations

Assessment of brain dopamine metabolism from plasma HVA and MHPG during debrisoquin treatment: Validation in monkeys treated with MPTP

1988 • 49 citations

Plasma catecholamine metabolites and treatment response at neuroleptic steady state

1989 • 48 citations

Use of alumina columns to prepare plasma samples for liquid-chromatographic determination of catecholamines.

1987 • 46 citations

Therapeutic effects of clozapine

1979 • 37 citations

Acute and chronic effects of neuroleptic drugs on plasma and brain homovanilic acid in the rat

1984 • 37 citations

Differential Alteration of Striatal D-1 and D-2 Receptors Induced by the Long-Term Administration of Haloperidol, Sulpiride or Clozapine to Rats

1985 • 31 citations

Interactions of neuroleptic compounds at α2-adrenergic receptor affinity states in bovine caudate nucleus

1983 • 21 citations

Relationship between urinary excretion of homovanillic acid and norepinephrine metabolites in normal subjects and patients with orthostatic hypotension

1988 • 19 citations