Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: Studies with chronic clozapine and haloperidol

Postsynaptic Supersensitivity after 6‐Hydroxy‐dopamine Induced Degeneration of the Nigro‐striatal Dopamine System

1971 • 1,922 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity

1977 • 716 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

Stimulation of locomotor activity following injection of dopamine into the nucleus accumbens

1973 • 477 citations

Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors

1977 • 304 citations

Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system

1973 • 296 citations

Neostriatal choline acetylase and cholinesterase following selective brain lesions

1971 • 279 citations

Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs.

1978 • 276 citations

Dopaminergic supersensitivity after neuroleptics: Time-course and specificity

1978 • 271 citations

Caudate nucleus neurones: correlation of the effects of substantia nigra stimulation with iontophoretic dopamine

1970 • 271 citations

Utilization of sodium-dependent high affinity choline uptake as a measure of the activity of cholinergic neurons

1975 • 269 citations

Amphetamine-Induced Dopaminergic Hypersensitivity in Guinea Pigs

1975 • 221 citations

Modulation of receptor mechanisms in the CNS: Hyper-and hyposensitivity to catecholamines

1978 • 221 citations

Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine

1975 • 206 citations

Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: Evidence for two different mechanisms of action

1978 • 198 citations

Influence of noncholinergic drugs on rat striatal acetylcholine levels

1974 • 160 citations

Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs

1978 • 149 citations

Levodopa‐Induced dopamine receptor hypersensitivity

1977 • 147 citations

Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.

1975 • 145 citations

A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic system

1976 • 115 citations

Regulation of striatal acetylcholine concentration by dopamine receptors

1974 • 112 citations

Acute and chronic amphetamine treatments modulate striatal dopamine receptor binding sites

1979 • 108 citations

Turnover times of gamma-aminobutyric acid and acetylcholine in nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra: effects of repeated administration of haloperidol

1977 • 103 citations

Psychotherapeutic Drugs

1976 • 91 citations

Neurometabolic and behavioural effects of haloperidol in relation to drug levels in serum and brain

1977 • 88 citations

Mesolimbic and Extrapyramidal Sites for the Mediation of Stereotyped Behaviour Patterns and Hyperactivity by Amphetamine and Apomorphine in the Rat

1977 • 71 citations

Dopamine release in N. accumbens and striatum by clozapine: Simultaneous monitoring by in vivo electrochemistry

1980 • 66 citations

METHODS OF NEUROCHEMISTRY, VOL. 1

1972 • 65 citations

Decrease in rat striatal acetylcholine levels by some direct- and indirect-acting dopaminergic antagonists

1975 • 56 citations

Correlation between drug-induced supersensitivity of dopamine dependent striatal mechanisms and the increase in striatal content of the Ca2+ regulated protein activator of cAMP phosphodiesterase

1977 • 46 citations

Dopamine antagonist binding increases in two behaviorally distinct striatal denervation syndromes

1979 • 45 citations

Enhancement of self-stimulation behavior in rats and monkeys after chronic neuroleptic treatment: Evidence for mesolimbic supersensitivity

1979 • 33 citations

Selective inhibition of mesolimbic behavioral supersensitivity by naloxone

1980 • 32 citations

Effects of morphine on choline acetyltransferase levels in the caudate nucleus of the rat

1971 • 31 citations

The pharmacological properties of a potent neurotropic compound from the dibenzothiazepine group

1965 • 29 citations

Tolerance to tyrosine hydroxylase activation in N. Accumbens and C. Striatum after repeated injections of “classical” and “atypical” antischizophrenic drugs

1978 • 28 citations

The effect of drugs on the choline and acetylcholine content of the rat striatum following two methods of sacrifice

1977 • 27 citations

Dopamine-receptor binding and adenylate-cyclase activity in mouse striatal tissue in the supersensitivity phase after neuroleptic treatment

1978 • 26 citations

Effects of chronic treatment with neuroleptics on striatal acetylcholine concentration¹

1976 • 24 citations

BRAIN ACETYLCHOLINE AND CHOLINESTERASE: EFFECT OF PHENOTHIAZINES AND PHYSOSTIGMINE INTERACTION IN RATS¹

1974 • 17 citations

Preferential effect of noncataleptogenic neuroleptics on mesolimbic dopaminergic function.

1977 • 17 citations

Advances in endogenous and exogenous opioids

1983 • 7 citations

Electron Microscopy of Negatively Stained tRNA

1973 • 3 citations

MECHANISMS OF SUPERSENSITIVITY IN THE ENKEPHALINERGIC SYSTEM

1981 • 2 citations