Serotonin function and treatment response to clozapine in schizophrenic patients

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

m-Chlorophenylpiperazine as a probe of serotonin function

1991 • 291 citations

Important Issues in the Drug Treatment of Schizophrenia

1980 • 286 citations

Comparative anxiogenic, neuroendocrine, and other physiologic effects of m-chlorophenylpiperazine given intravenously or orally to healthy volunteers

1989 • 202 citations

Neuroendocrine Effects ofM-Chlorophenylpiperazine, a Serotonin Agonist, in Humans

1985 • 181 citations

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites

1990 • 173 citations

Hormonal probes of central serotonergic activity: Do they really exist?

1987 • 148 citations

Clozapine, Chlorpromazine, and Placebo in Newly Hospitalized, Acutely Schizophrenic Patients

1979 • 146 citations

In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: Implications for drug mechanisms of action

1986 • 128 citations

Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity

1988 • 77 citations

Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain

1984 • 74 citations

Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat

1988 • 74 citations

The MCPP challenge test in schizophrenia: Hormonal and behavioral responses

1991 • 69 citations

Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats

1984 • 69 citations

Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: Studies with chronic clozapine and haloperidol

1982 • 67 citations

Effects of serotonin antagonists on m-chlorophenylpiperazine-mediated responses in normal subjects

1990 • 50 citations

Serotonin function in schizophrenia: Effects of meta- chlorophenylpiperazine in schizophrenia patients and healthy subjects

1992 • 49 citations

Clozapine versus Perphenazine: The Value of the Biochemical Mode of Action of Neuroleptics in Predicting their Therapeutic Activity

1976 • 43 citations

Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies

1990 • 43 citations

High-performance liquid chromatographic method for the analysis of plasma m-chlorophenylpiperazine

1990 • 39 citations

Differential Alteration of Striatal D-1 and D-2 Receptors Induced by the Long-Term Administration of Haloperidol, Sulpiride or Clozapine to Rats

1985 • 31 citations

MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment

1991 • 6 citations