Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Drugs, Neurotransmitters, and Schizophrenia

1974 • 832 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Serotonergic component of neuroleptic receptors

1978 • 621 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 541 citations

Dopamine-Sensitive Adenylate Cyclase in Mammalian Brain: A Possible Site of Action of Antipsychotic Drugs

1974 • 450 citations

3H-spiroperidol labels dopamine receptors in pituitary and brain

1977 • 406 citations

Dopamine receptor binding: Differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol

1975 • 390 citations

Chemotherapy in Psychiatry

2012 • 358 citations

IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.

1965 • 348 citations

Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system

1973 • 296 citations

Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain

1977 • 290 citations

The Action of Neuroleptic Drugs on Dopamine-Stimulated Adenosine Cyclic 3',5'-Monophosphate Production in Rat Neostriatum and Limbic Forebrain

1974 • 240 citations

Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine.

1978 • 230 citations

HETEROGENEITY OF HISTAMINE Hi‐RECEPTORS: SPECIES VARIATIONS IN [³H]MEPYRAMINE BINDING OF BRAIN MEMBRANES

1979 • 225 citations

3H-spiroperidol labels serotonin receptors in rat cerebral cortex and hippocampus

1978 • 206 citations

Neurotransmitter Receptors in the Brain: Biochemical Identification

1976 • 186 citations

The dopamine receptor: Differential binding of d-LSD and related agents to agonist and antagonist states

1975 • 165 citations

Tricyclic antidepressants block histamine H1 receptors of mouse neuroblastoma cells

1978 • 108 citations

Chemotherapy in Psychiatry

1977 • 98 citations

Comparison of the effects of substituted benzamides and standard neuroleptics on the binding of 3H-spiroperidol in the rat pituitary and striatum with effects on rat prolactin secretion

1979 • 70 citations

Butaclamol hydrochloride (AY-23,028): an early evaluation in severely ill schizophrenics.

1975 • 11 citations