Interleukin-1β-converting enzyme-deficient mice resist central but not systemic endotoxin-induced anorexia

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

Biological basis of the behavior of sick animals

1988 • 2,123 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

1995 • 1,413 citations

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

1988 • 414 citations

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.

1992 • 319 citations

Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS

1995 • 300 citations

Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat

1992 • 299 citations

Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism

1995 • 228 citations

Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropin-releasing hormone neurons and ACTH secretion.

1995 • 214 citations

Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice

1994 • 199 citations

Effect of endotoxin in IL-1 beta-deficient mice.

1996 • 190 citations

Anorexia induced by cytokine interactions at pathophysiological concentrations

1996 • 186 citations

Mechanisms of sickness-induced decreases in food-motivated behavior

1996 • 184 citations

Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally

1996 • 162 citations

The inflammatory response in interleukin-1β-deficient mice: comparison with other cytokine-related knock-out mice

1996 • 160 citations

Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin

1994 • 154 citations

The role of interleukin-1 and tumor necrosis factor α in the neurochemical and neuroendocrine responses to endotoxin

1992 • 148 citations

Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide

1996 • 126 citations

Stress Downregulates Lipopolysaccharide-Induced Expression of Proinflammatory Cytokines in the Spleen, Pituitary, and Brain of Mice

1995 • 105 citations

Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1β

1992 • 94 citations

Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing factor

1991 • 91 citations

Characterization of mice deficient in interleukin-1β converting enzyme

1997 • 86 citations

Evidence for a direct central anorectic effect of tumor-necrosis-factor-alpha in the rat

1993 • 78 citations

Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats

1995 • 78 citations

Corticosterone modulates behavioral and metabolic effects of lipopolysaccharide

1996 • 67 citations

Centrally administered bacterial lipopolysaccharide depresses feeding in rats

1993 • 65 citations

Synergistic effect of rhTNF-alpha and rhIL-1 alpha in inducing anorexia in rats

1994 • 55 citations

Immunology discovers physiology

1994 • 54 citations

Endogenous glucocorticoids down regulate central effects of interleukin-1 β on body temperature and behaviour in mice

1995 • 48 citations

Proinflammatory Cytokines as Pathogenetic Mediators in the Central Nervous System: Brain-Periphery Connections

1995 • 41 citations

Effects of lipopolysaccharide and glucocorticoids on expression of interleukin-1β converting enzyme in the pituitary and brain of mice

1996 • 40 citations

Peripheral Endocrine and Metabolic Responses to Centrally Administered lnterleukin-1

1994 • 23 citations