Temperature-dependent tyrosine phosphorylation of microtubule-associated protein kinase in epidermal growth factor-stimulated human fibroblasts.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Oncogenes and signal transduction

1991 • 2,816 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Epidermal growth factor.

1990 • 1,645 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton.

1989 • 457 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1991 • 422 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies.

1991 • 392 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.

1988 • 166 citations

Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.

1991 • 157 citations

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.

1990 • 142 citations

Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes.

1990 • 141 citations

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

1985 • 125 citations

Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts.

1983 • 118 citations

Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1.

1988 • 110 citations

Rapid microassay for protein kinase C translocation in Swiss 3T3 cells

1986 • 100 citations

Lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis

1982 • 93 citations

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.

1991 • 92 citations

Cell Cycle Tyrosine Phosphorylation of p34^cdc2 and a Microtubule- Associated Protein Kinase Homolog in Xenopus Oocytes and Eggs

1991 • 79 citations

Role of protein phosphorylation in the maturation-induced activation of a myelin basic protein kinase from sea star oocytes.

1991 • 65 citations

Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

1991 • 62 citations

Tyrosine Phosphorylation and Activation of Homologous Protein Kinases during Oocyte Maturation and Mitogenic Activation of Fibroblasts

1991 • 61 citations

Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells

1991 • 59 citations

Major Substrate for Growth Factor-Activated Protein-Tyrosine Kinases Is a Low-Abundance Protein

1985 • 54 citations

Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells.

1991 • 52 citations

Related Proteins Are Phosphorylated at Tyrosine in Response to Mitogenic Stimuli and at Meiosis

1989 • 42 citations

Mitogen‐stimulated tyrosine phosphorylation of a 42‐kD cellular protein: Evidence for a protein kinase‐C requirement

1988 • 40 citations

Insulin-like effects of epidermal growth factor and insulin-like growth factor-I on [3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes

1989 • 33 citations

Tyrosine Phosphorylation of Specific Proteins After Mitogen Stimulation of Chicken Embryo Fibroblasts

1983 • 33 citations

Defective Regulation of Mitogen-Activated Protein Kinase Activity in a 3T3 Cell Variant Mitogenically Nonresponsive to Tetradecanoyl Phorbol Acetate

1991 • 26 citations

Identification of a major maturation-activated acetyl-CoA carboxylase kinase in sea star oocytes as p44mpk

1991 • 25 citations