In microdissected ductal carcinoma in situ, HER-2/neu amplification, but notp53 mutation, is associated with high nuclear grade and comedo histology

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

1992 • 757 citations

Mammographically detected duct carcinoma in situ. Frequency of local recurrence following tylectomy and prognostic effect of nuclear grade on local recurrence

1989 • 563 citations

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

1994 • 513 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Fifteen-year results of breast-conserving surgery and definitive breast irradiation for the treatment of ductal carcinoma in situ of the breast.

1996 • 361 citations

Loss of Tumor Marker-Immunostaining Intensity on Stored Paraffin Slides of Breast Cancer

1996 • 294 citations

HER-2/neu (c-erb-B2) gene and protein in breast cancer.

1999 • 285 citations

Heterogeneity of intraductai carcinoma of the breast

1989 • 250 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

Consensus conference on the classification of ductal carcinoma in Situ

1997 • 236 citations

Ductal carcinoma in situ (intraductal carcinoma) of the breast treated with breast-conserving surgery and definitive irradiation correlation of pathologic parameters with outcome of treatment

1993 • 209 citations

A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group.

1997 • 198 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Immunohistochemical demonstration of c-erbB-2 protein in mammary ductal carcinoma in situ

1990 • 163 citations

p53 protein expression in mammary ductal carcinoma in situ: Relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein

1993 • 157 citations

Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation

1994 • 152 citations

Variability of immunohistochemical reactivity on stored paraffin slides.

1998 • 149 citations

Mammographically-detected ductal in situ carcinoma of the breast analyzed with a new classification. A study of 127 cases: correlation with estrogen and progesterone receptors, p53 and c-erbB-2 proteins, and proliferative activity.

1994 • 147 citations

Polymorphism at codon 213 within the p53 gene.

1991 • 137 citations

Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c-erbB-2 protein

1995 • 132 citations

The classification of ductal carcinoma in situ and its association with biological markers.

1994 • 128 citations

HER-2/neu Amplification in Benign Breast Disease and the Risk of Subsequent Breast Cancer

2000 • 127 citations

Optimization of immunohistochemical detection of ERBB2 in human breast cancer: Impact of fixation

1994 • 123 citations

Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast.

1990 • 122 citations

Immunohistochemical Detection of c-erbB-2 and p53 in Benign Breast Disease and Breast Cancer Risk

1998 • 108 citations

c-erbB-2 overexpression and histological type of in situ and invasive breast carcinoma.

1992 • 102 citations

Analysis of gene amplification in archival tissue by differential polymerase chain reaction.

1992 • 87 citations

p53 mutations in benign breast tissue.

1995 • 78 citations

Immunophenotype of intraductal carcinoma.

1996 • 77 citations

p53 mutations in mammary ductal carcinoma in situ but not in epithelial hyperplasias.

1998 • 66 citations

Pattern of gene alterations in intraductal breast neoplasms associated with histological type and grade.

1995 • 54 citations

Expression of proliferation and apoptosis-related proteins in usual ductal hyperplasia of the breast

1998 • 54 citations

Analysis of cerbB2 expression using a panel of 6 commercially available antibodies

1994 • 53 citations

Immunohistochemical expression of the mutant p53 protein and nuclear DNA content during the transition from benign to malignant breast disease

1994 • 52 citations

Ductal carcinoma in situ of the breast: correlation between histologic classifications and biologic markers.

1997 • 49 citations

p53 protein expression in ductal carcinoma in situ (DCIS) of the breast

1997 • 42 citations

Maintenance of DNA content and erbB-2 alterations in intraductal and invasive phases of mammary cancer

1995 • 42 citations

TP53 alterations in atypical ductal hyperplasia and ductal carcinomain situ of the breast

1996 • 29 citations

Modulation of biomarkers in minimal breast carcinoma

1998 • 24 citations

Microdissection and Molecular Genetic Analysis of HER2/neu in Breast Carcinoma

1995 • 21 citations

Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ

1996 • 21 citations