Back to search

Gel Kinetic Analysis of DNA Polymerase Fidelity in the Presence of Proofreading Using Bacteriophage T4 DNA Polymerase

Data up to Jan 2025

Published1995
Citations73
References47

Total Citations Per Year

Abstract

References (47)

Stochastic Processes in Physics and Chemistry

2007 • 9,372 citations

Stochastic Processes in Physics and Chemistry

1992 • 3,278 citations

Enzyme structure and mechanism

1977 • 2,935 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1972 • 594 citations

Enzyme Structure and Mechanism

1978 • 573 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Biochemical Basis of DNA Replication Fidelity

1993 • 441 citations

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

1991 • 364 citations

Kinetic mechanism of DNA polymerase I (Klenow)

1987 • 352 citations

Studies on the Biochemical Basis of Spontaneous Mutation

1972 • 340 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

1990 • 293 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Mutagenesis by transient misalignment.

1988 • 265 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Kinetic characterization of the polymerase and exonuclease activities of the gene 43 protein of bacteriophage T4

1992 • 207 citations

An in vitro transversion by a mutationally altered T4-induced DNA polymerase

1968 • 190 citations

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

1986 • 177 citations

Studies on the biochemical basis of spontaneous mutation

1974 • 170 citations

Error induction and correction by mutant and wild type T4 DNA polymerases. Kinetic error discrimination mechanisms.

1979 • 167 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates.

1992 • 145 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID, X. INFLUENCE OF BROMOURACIL SUBSTITUTIONS ON REPLICATION

1962 • 110 citations

Hydrolysis of Template and Newly Synthesized Deoxyribonucleic Acid by the 3′ to 5′ Exonuclease Activity of the T4 Deoxyribonucleic Acid Polymerase

1972 • 105 citations

Pre-Steady-State Kinetic Analysis of Sequence-Dependent Nucleotide Excision by the 3'-Exonuclease Activity of Bacteriophage T4 DNA Polymerase

1994 • 99 citations

Introduction to stochastic models

1987 • 98 citations

Influence of neighboring bases on DNA polymerase insertion and proofreading fidelity.

1985 • 98 citations

Enzymatic determinants of DNA polymerase accuracy. Theory of coliphage T4 polymerase mechanisms

1978 • 90 citations

Processive proofreading is intrinsic to T4 DNA polymerase.

1992 • 87 citations

Influence of 5'-nearest neighbors on the insertion kinetics of the fluorescent nucleotide analog 2-aminopurine by Klenow fragment

1993 • 86 citations

Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-)

1991 • 81 citations

Studies on the biochemical basis of spontaneous mutation

1977 • 76 citations

Kinetic Analysis of Base Substitution Mutagenesis by Transient Misalignment of DNA and by Miscoding

1989 • 70 citations

Kinetics of deoxyribonucleotide insertion and extension at abasic template lesions in different sequence contexts using HIV-1 reverse transcriptase.

1993 • 58 citations

Multi-stage proofreading in DNA replication

1993 • 56 citations

On the fidelity of DNA replication. The accuracy of T4 DNA polymerases in copying phi X174 DNA in vitro.

1984 • 53 citations

Influence of template primary and secondary structure on the rate and fidelity of DNA synthesis.

1985 • 48 citations

The half-of-the-sites reactivity of horse liver alcohol dehydrogenase in the presence of alcohol substrates

1974 • 44 citations

Mutagen specificity and position effects on mutation in T4rII nonsense sites

1976 • 43 citations

Influence of local nucleotide sequence on substitution of 2-aminopurine for adenine during deoxyribonucleic acid synthesis in vitro

1983 • 39 citations

A new approach to DNA polymerase kinetics

1979 • 33 citations

Specificity and efficiency of editing of mismatches involved in the formation of base-substitution mutations by the 3'----5' exonuclease activity of phage T4 DNA polymerase.

1987 • 23 citations

A fidelity assay using "dideoxy" DNA sequencing: a measurement of sequence dependence and frequency of forming 5-bromouracil X guanine base mispairs.

1985 • 23 citations

Cited By (0)

No citing papers found in database

Gel Kinetic Analysis of DNA Polymerase Fidelity in the Presence of Proofreading Using… (1995) – Journal of Biological Chemistry | Metascience Observatory Explorer