p38 Mitogen-activated Protein Kinase and Extracellular Signal-regulated Kinases Play Distinct Roles in the Activation of Dendritic Cells by Two Representative Haptens, NiCl2 and 2,4-dinitrochlorobenzene

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

LPS induction of gene expression in human monocytes

2001 • 2,276 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

1998 • 1,448 citations

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

1998 • 1,190 citations

Dendritic Cell Survival and Maturation Are Regulated by Different Signaling Pathways

1998 • 685 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Cutting Edge: Secondary Lymphoid-Tissue Chemokine (SLC) and CC Chemokine Receptor 7 (CCR7) Participate in the Emigration Pathway of Mature Dendritic Cells from the Skin to Regional Lymph Nodes

1999 • 621 citations

Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies.

1987 • 592 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

Regulation and function of the JNK subgroup of MAP kinases

1997 • 484 citations

The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte–derived dendritic cells

2000 • 440 citations

A Critical Role for p38 Mitogen-Activated Protein Kinase in the Maturation of Human Blood-Derived Dendritic Cells Induced by Lipopolysaccharide, TNF-α, and Contact Sensitizers

2001 • 404 citations

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice

1999 • 390 citations

Cultured Human Langerhans Cells Resemble Lymphoid Dendritic Cells in Phenotype and Function

1989 • 376 citations

p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages.

1999 • 296 citations

Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co‐stimulatory molecules

1997 • 252 citations

The role of p38 mitogen-activated protein kinase in IL-1 beta transcription.

1999 • 241 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

The Role of p38 Mitogen-Activated Protein Kinase in IL-1β Transcription

1999 • 212 citations

Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling

2001 • 182 citations

Contact Allergens and Epidermal Proinflammatory Cytokines Modulate Langerhans Cell E-cadherin Expression in Situ

1996 • 176 citations

An Essential Role for CD44 Variant Isoforms in Epidermal Langerhans Cell and Blood Dendritic Cell Function

1997 • 176 citations

Expression and function of B7 on human epidermal Langerhans cells.

1993 • 166 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Interleukin-1β and Granulocyte-Macrophage Colony-Stimulating Factor Mediate Langerhans Cell Maturation Differently

1996 • 96 citations

Langerhans’ cells produce type IV collagenase (MMP‐9) following epicutaneous stimulation with haptens

1997 • 81 citations

In vitro treatment of human transforming growth factor‐β₁‐treated monocyte‐derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction

2000 • 80 citations

Up-Regulation of α4 Integrin on Activated Langerhans Cells: Analysis of Adhesion Molecules on Langerhans Cells Relating to Their Migration from Skin to Draining Lymph Nodes

1993 • 68 citations

Induction of Tyrosine Phosphorylation in Human MHC Class II-Positive Antigen-Presenting Cells by Stimulation with Contact Sensitizers

1998 • 61 citations

Expression of Maturation-/Migration-Related Molecules on Human Dendritic Cells from Blood and Skin

1998 • 60 citations

Expression of B7 Costimulatory Molecule in Cultured Human Epidermal Langerhans Cells Is Regulated at the mRNA Level

1994 • 53 citations

Human Epidermal Langerhans Cells Express β1 Integrins that Mediate Their Adhesion to Laminin and Fibronectin

1992 • 28 citations

Signal transduction triggered by lipid A-like molecules in 70Z/3 pre-B lymphocyte tumor cells

1999 • 4 citations