p38 but not p44/42 mitogen-activated protein kinase is required for nitric oxide synthase induction mediated by lipopolysaccharide in RAW 264.7 macrophages.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (45)
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
1996 • 5,936 citations
NITRIC OXIDE AND MACROPHAGE FUNCTION
1997 • 4,106 citations
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
1990 • 4,041 citations
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
1994 • 3,219 citations
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
1994 • 2,659 citations
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
1995 • 2,238 citations
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.
1994 • 2,216 citations
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
1997 • 2,137 citations
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
1992 • 1,524 citations
NF-κB: A lesson in family values
1995 • 1,266 citations
Identification and Characterization of an IκB Kinase
1997 • 1,166 citations
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
1993 • 1,141 citations
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
1993 • 1,129 citations
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.
1993 • 1,127 citations
The MAP kinase cascade is essential for diverse signal transduction pathways
1993 • 1,091 citations
Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.
1993 • 1,077 citations
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
1993 • 1,047 citations
Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity
1996 • 960 citations
MAPKs: new JNK expands the group
1994 • 949 citations
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
1992 • 877 citations
IκB-β regulates the persistent response in a biphasic activation of NF-κB
1995 • 780 citations
Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†
1996 • 717 citations
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.
1993 • 639 citations
Macrophages and Inflammatory Mediators in Tissue Injury
1995 • 613 citations
The search for physiological substrates of MAP and SAP kinases in mammalian cells
1997 • 544 citations
Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages.
1996 • 475 citations
Diversity in function and regulation of MAP kinase pathways
1994 • 469 citations
Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages.
1992 • 402 citations
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14.
1993 • 302 citations
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
1991 • 291 citations
Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages
1993 • 249 citations
Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.
1996 • 240 citations
Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB
1996 • 228 citations
Lipopolysaccharide Signals Activation of Tumor Necrosis Factor Biosynthesis Through the Ras/Raf-1/MEK/MAPK Pathway
1994 • 228 citations
Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages.
1996 • 215 citations
Lipopolysaccharide induces activation of the Raf-1/MAP kinase pathway. A putative role for Raf-1 in the induction of the IL-1 beta and the TNF-alpha genes.
1994 • 146 citations
Antisense oligonucleotides targeting protein kinase C-alpha, -beta I, or -delta but not -eta inhibit lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages: involvement of a nuclear factor kappa B-dependent mechanism.
1998 • 122 citations
Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events.
1995 • 115 citations
Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14
1996 • 114 citations
A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial Cells
1996 • 110 citations
Protein Kinase C η Mediates Lipopolysaccharide-induced Nitric-oxide Synthase Expression in Primary Astrocytes
1998 • 106 citations
Mechanism for Biphasic Rel A· NF-κB1 Nuclear Translocation in Tumor Necrosis Factor α-stimulated Hepatocytes
1997 • 103 citations
Evidence for Common Mechanisms in the Transcriptional Control of Type II Nitric Oxide Synthase in Isolated Hepatocytes
1996 • 100 citations
ATP-induced arachidonic acid release in cultured astrocytes is mediated by Gi protein coupled P2Y1 and P2Y2 receptors
1998 • 58 citations
Role of protein kinase C subtypes alpha and delta in the regulation of bradykinin-stimulated phosphoinositide breakdown in astrocytes.
1995 • 48 citations