Activation of protein kinase C in human neutrophils attenuates agonist-stimulated rises in cytosolic free Ca2+ concentration by inhibiting bivalent-cation influx and intracellular Ca2+ release in addition to stimulating Ca2+ efflux

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

1989 • 520 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

Agonists stimulate divalent cation channels in the plasma membrane of human platelets

1985 • 303 citations

Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux.

1984 • 272 citations

Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium

1983 • 217 citations

Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2

1984 • 203 citations

Exogenous ATP raises cytoplasmic free calcium in fura‐2 loaded piglet aortic endothelial cells

1986 • 200 citations

Phorbol esters inhibit the fMet-Leu-Phe- and leukotriene B4-stimulated calcium mobilization and enzyme secretion in rabbit neutrophils.

1985 • 196 citations

Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.

1984 • 193 citations

A diacylglycerol analogue reduces neuronal calcium currents independently of protein kinase C activation

1989 • 190 citations

Nucleotide regulatory protein-mediated activation of phospholipase C in human polymorphonuclear leukocytes is disrupted by phorbol esters.

1987 • 184 citations

Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.

1985 • 179 citations

Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.

1984 • 177 citations

Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells

1985 • 176 citations

Tumour‐promoting phorbol esters inhibit agonist‐induced phosphatidate formation and Ca²⁺ flux in human platelets

1985 • 173 citations

Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms.

1988 • 166 citations

Regulation of erythrocyte Ca2+ pump activity by protein kinase C.

1988 • 160 citations

Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

1986 • 157 citations

Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation.

1988 • 133 citations

Rapid increases in cytosolic free calcium in response to muscarinic stimulation of rat parotid acinar cells.

1987 • 124 citations

Calcium influx stimulates a second pathway for sustained diacylglycerol production in leukocytes activated by chemoattractants.

1988 • 119 citations

Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes.

1985 • 119 citations

Receptor-mediated Ca2+ entry: diversity of function and mechanism

1989 • 105 citations

Stimulation of Ca²⁺ efflux from fura‐2‐loaded platelets activated by thrombin or phorbol myristate acetate

1987 • 96 citations

Calcium fluxes and calcium buffering in human neutrophils.

1986 • 89 citations

Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe‐stimulated neutrophils

1985 • 88 citations

Stimulated calcium efflux from fura‐2‐loaded human platelets.

1987 • 88 citations

Evidence that phorbol ester interferes with stimulated Ca2+ redistribution by activating Ca2+ efflux in neutrophil leucocytes

1985 • 76 citations

Phorbol 12, myristate 13, acetate potentiates the respiratory burst while inhibits phosphoinositide hydrolysis and calcium mobilization by formyl-methionyl-leucyl-phenylalanine in human neutrophils

1986 • 73 citations

Role of cytosolic free calcium and phospholipase C in leukotrien‐B4‐stimulated secretion in human neutrophils

1987 • 45 citations

Analysis of Calcium Homeostasis in Activated Human Polymorphonuclear Leukocytes

1989 • 28 citations

Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters

1987 • 22 citations

Synthetic Diacylglycerols Trigger an Increase of Intracellular Free Calcium in Promyelocytic HL60 Cells

1989 • 22 citations

Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes

1987 • 16 citations