Human Resident Langerhans Cells Display a Lysosomal compartment Enriched in MHC Class II

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 • 846 citations

An Electron Microscope Study of Basal Melanocytes and High-Level Clear Cells (Langerhans Cells) in Vitiligo**From the Chester Beatty Research Institute, Royal Cancer Hospital, London, S.W. 3, and the Departments of Anatomy, and Dermatology, St. Mary's Hospital Medical School (University of London) London, W. 2, England.

1961 • 812 citations

Immunologic Functions of Ia-Bearing Epidermal Langerhans Cells

1978 • 732 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells.

1989 • 542 citations

Antigen-bearing Langerhans cells in skin, dermal lymphatics and in lymph nodes

1976 • 510 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections.

1981 • 387 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Possible pathways for lysosomal enzyme delivery.

1985 • 253 citations

Liposome-encapsulated antigens are processed in lysosomes, recycled, and presented to T cells

1991 • 250 citations

Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles.

1988 • 241 citations

Glomerular filtration of proteins: Clearance of anionic, neutral, and cationic horseradish peroxidase in the rat

1978 • 239 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

1993 • 221 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Human Epidermal Langerhans Cells Undergo Profound Morphologic and Phenotypical Changes During In Vitro Culture

1990 • 210 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Differences in the endosomal distributions of the two mannose 6-phosphate receptors.

1993 • 185 citations

In vitro evidence that Langerhans cells can adopt two functionally distinct forms capable of antigen presentation to T lymphocytes.

1989 • 177 citations

Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells.

1992 • 167 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain.

1991 • 145 citations

Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.

1985 • 135 citations

Immunogenic peptides bind to class II MHC molecules in an early lysosomal compartment.

1993 • 124 citations

Quantitation of Surface Antigens on Cultured Murine Epidermal Langerhans Cells: Rapid and Selective Increase in the Level of Surface MHC Products

1988 • 103 citations

9 Localization of Macromolecular Components by Application of the Immunogold Technique on Cryosectioned Bacteria

1988 • 88 citations

Hepatitis B surface antigen in urine of hemodialysis patients

1978 • 76 citations

Epidermal Cell-Induced Generation of Cytotoxic T-Lymphocyte Responses Against Alloantigens or TNP-Modified Syngeneic Cells: Requirement for Ia-Positive Langerhans Cells

1983 • 62 citations

The Langerhans Cell Granule Is an Adsorptive Endocytic Organelle

1985 • 54 citations

Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74).

1991 • 53 citations

Cytomembrane-Derived Birbeck Granules Transport Horseradish Peroxidase to the Endosomal Compartment in the Human Langerhans Cells

1992 • 46 citations

Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells

1991 • 42 citations

HLA class II expression on human epidermal langerhans cells in situ: Upregulation during the elicitation of allergic contact dermatitis

1992 • 41 citations

Localization of Class II Molecules in Storage Vesicles, Endosomes and Lysosomes in Human Dendritic Cells

1991 • 25 citations