Optimal primer design using the novel primer design program: MSPprimer provides accurate methylation analysis of the ATM promoter

MGMTGene Silencing and Benefit from Temozolomide in Glioblastoma

2005 • 6,591 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Gene Silencing in Cancer in Association with Promoter Hypermethylation

2003 • 3,332 citations

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

1992 • 3,099 citations

MethPrimer: designing primers for methylation PCRs

2002 • 2,493 citations

Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating Agents

2000 • 2,127 citations

High sensitivity mapping of methylated cytosines

1994 • 1,863 citations

COBRA: a sensitive and quantitative DNA methylation assay

1997 • 1,184 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

Improved Nearest-Neighbor Parameters for Predicting DNA Duplex Stability

1996 • 829 citations

Thermodynamics and NMR of Internal G·T Mismatches in DNA

1997 • 588 citations

Nearest-Neighbor Thermodynamics and NMR of DNA Sequences with Internal A·A, C·C, G·G, and T·T Mismatches

1999 • 560 citations

AutoDimer: a screening tool for primer-dimer and hairpin structures

2004 • 497 citations

Functional Diversity of DNA Methyltransferase Inhibitors in Human Cancer Cell Lines

2006 • 380 citations

Effects of Sodium Ions on DNA Duplex Oligomers: Improved Predictions of Melting Temperatures

2004 • 321 citations

Nearest-Neighbor Thermodynamics of Internal A·C Mismatches in DNA: Sequence Dependence and pH Effects

1998 • 251 citations

Nearest Neighbor Thermodynamic Parameters for Internal G·A Mismatches in DNA

1998 • 239 citations

Thermodynamics of internal C.T mismatches in DNA

1998 • 236 citations

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL

2005 • 233 citations

Gene Promoter Methylation in Plasma and Sputum Increases with Lung Cancer Risk

2005 • 208 citations

BiSearch: primer-design and search tool for PCR on bisulfite-treated genomes

2005 • 183 citations

Activation of the p53 DNA Damage Response Pathway after Inhibition of DNA Methyltransferase by 5-Aza-2′-deoxycytidine

2001 • 174 citations

Methylation Profiling of Archived Non–Small Cell Lung Cancer: A Promising Prognostic System

2005 • 125 citations

The ATM gene is a target for epigenetic silencing in locally advanced breast cancer

2004 • 105 citations

Ataxia-Telangiectasia-Mutated ( ATM ) Gene in Head and Neck Squamous Cell Carcinoma

2004 • 99 citations

Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line

2002 • 95 citations

CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype

2005 • 89 citations

ATM mutations are associated with inactivation of theARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma

2002 • 81 citations

Analysis of 11q21–24 loss of heterozygosity candidate target genes in breast cancer: Indications of TSLC1 promoter hypermethylation

2002 • 80 citations

Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy

2004 • 66 citations

Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity

2006 • 62 citations

The ATM/p53 pathway is commonly targeted for inactivation in squamous cell carcinoma of the head and neck (SCCHN) by multiple molecular mechanisms

2005 • 53 citations

Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL.

1998 • 49 citations

A novel strategy to design highly specific PCR primers based on the stability and uniqueness of 3′-end subsequences

2005 • 36 citations

ATM promoter analysis in childhood lymphoid malignancies: A brief communication

2005 • 15 citations