Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity

The 2007 WHO Classification of Tumours of the Central Nervous System

2007 • 13,561 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

The WHO Classification of Tumors of the Nervous System

2002 • 1,931 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

2000 • 1,182 citations

DNA methylation and gene silencing in cancer

2005 • 1,110 citations

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

2005 • 692 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Predominance of null mutations in ataxia-telangiectasia

1996 • 293 citations

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.

1996 • 251 citations

Molecular pathology of ataxia telangiectasia

2005 • 240 citations

Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

2002 • 225 citations

ATM signaling and genomic stability in response to DNA damage

2004 • 209 citations

Radiosensitivity in Ataxia-telangiectasia: Anomalies in Radiation-induced Cell Cycle Delay

1994 • 192 citations

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

1995 • 167 citations

Splitting the ATM: distinct repair and checkpoint defects in ataxia–telangiectasia

1998 • 160 citations

Contributions of ATM mutations to familial breast and ovarian cancer.

2003 • 158 citations

Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system

2000 • 150 citations

Ataxia telangiectasia gene mutations in leukaemia and lymphoma

2001 • 146 citations

ATM gene and lymphoid malignancies

2003 • 115 citations

Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53

2001 • 107 citations

The ATM gene is a target for epigenetic silencing in locally advanced breast cancer

2004 • 105 citations

Ataxia-Telangiectasia-Mutated ( ATM ) Gene in Head and Neck Squamous Cell Carcinoma

2004 • 99 citations

Aberrant methylation of the ATM promoter correlates with increased radiosensitivity in a human colorectal tumor cell line

2002 • 95 citations

ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture

2001 • 82 citations

Expression of Glial and Vimentin Type Intermediate Filaments in Cultures Derived from Human Glial Material

1981 • 67 citations

Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer

2003 • 58 citations

Ionizing Radiation and Cell Cycle Progression in Ataxia Telangiectasia

1994 • 49 citations

Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity.

1999 • 35 citations

Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells

2004 • 32 citations

Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway

2000 • 21 citations

Chromosomal breakage correlates with delayed lethality in normal and ataxia telangiectasia cell lines treated with bleomycin

1996 • 6 citations