Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Applications of the Morris water maze in the study of learning and memory

2001 • 1,926 citations

Protein Kinase C: Structure, Function, and Regulation

1995 • 1,640 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

A Portrait of Alzheimer Secretases--New Features and Familiar Faces

2001 • 492 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Calcium-Mediated Reduction of Ionic Currents: A Biophysical Memory Trace

1984 • 399 citations

Memory-enhancing effects of secreted forms of the β-amyloid precursor protein in normal and amnestic mice

1998 • 350 citations

Memory function in very early Alzheimer's disease

1994 • 335 citations

Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network

2000 • 320 citations

Standardization of measurement of β-amyloid_(1-42)in cerebrospinal fluid and plasma

2000 • 301 citations

Aβ-Generating Enzymes

2000 • 298 citations

Evidence for the Biosynthesis of Bryostatins by the Bacterial Symbiont “ Candidatus Endobugula sertula” of the Bryozoan Bugula neritina

2001 • 268 citations

Protein kinase Cδ

1999 • 243 citations

Decreased levels of protein kinase C in Alzheimer brain

1988 • 242 citations

Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.

1994 • 237 citations

Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice

2002 • 235 citations

Regulation of the α‐secretase ADAM10 by its prodomain and proprotein convertases

2001 • 232 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

Turnover of Amyloid β-Protein in Mouse Brain and Acute Reduction of Its Level by Phorbol Ester

1998 • 213 citations

Chemistry and clinical biology of the bryostatins

2000 • 178 citations

Soluble β-Amyloid Induction of Alzheimer's Phenotype for Human Fibroblast K ⁺ Channels

1994 • 168 citations

Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

2000 • 166 citations

Protein kinase C inhibits amyloid β‐peptide neurotoxicity by acting on members of the Wnt pathway

2002 • 160 citations

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

1993 • 144 citations

Time domains of neuronal Ca2+ signaling and associative memory: steps through a calexcitin, ryanodine receptor, K+ channel cascade

1998 • 135 citations

Attenuated protein kinase C activity and translocation in Alzheimer's Disease brain

1994 • 118 citations

The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1

1998 • 109 citations

Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients

1993 • 105 citations

Aging Increased Amyloid Peptide and Caused Amyloid Plaques in Brain of Old APP/V717I Transgenic Mice by a Different Mechanism than Mutant Presenilin1

2000 • 101 citations

Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

2000 • 97 citations

Alzheimer’s-specific effects of soluble β-amyloid on protein kinase C-α and -γ degradation in human fibroblasts

1998 • 76 citations

Age-related alteration of PKC, a key enzyme in memory processes

1998 • 76 citations

Conventional protein kinase C (PKC)‐α and novel PKCε, but not ‐δ, increase the secretion of an N‐terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

1995 • 70 citations

Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis

1999 • 70 citations

Modeling, Chemistry, and Biology of the Benzolactam Analogues of Indolactam V (ILV). 2. Identification of the Binding Site of the Benzolactams in the CRD2 Activator-Binding Domain of PKCδ and Discovery of an ILV Analogue of Improved Isozyme Selectivity

1997 • 67 citations

An Etiological Role of Amyloidogenic Carboxyl‐Terminal Fragments of the β‐Amyloid Precursor Protein in Alzheimer's Disease

1997 • 64 citations

Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C.

1996 • 56 citations

Blockade of PKCϵ Activation Attenuates Phorbol Ester-Induced Increase of α-Secretase-Derived Secreted Form of Amyloid Precursor Protein

2001 • 51 citations

Amyloid β Peptide Formation in Cell-free Preparations

1996 • 49 citations

New Amide-Bearing Benzolactam-Based Protein Kinase C Modulators Induce Enhanced Secretion of the Amyloid Precursor Protein Metabolite sAPPα

2002 • 43 citations

Structure-Based Design of a New Class of Protein Kinase C Modulators

1998 • 37 citations

Alzheimer’s Disease in Man and Transgenic Mice

2001 • 33 citations

Protein kinase Cα and β1 isoforms are regulators of α‐secretory proteolytic processing of amyloid precursor protein in vivo

2001 • 30 citations

Regulation of Amyloid Precursor Protein (APP) Secretion by Protein Kinase Cα in Human Ntera 2 Neurons (NT2N)

2000 • 29 citations

Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug

1999 • 27 citations

Characterization and Distribution of Protein Kinase C Isoforms in Human Skin Fibroblasts

1994 • 27 citations

The Transient Increase of Tight Junction Permeability Induced by Bryostatin 1 Correlates with Rapid Downregulation of Protein Kinase C-α

2000 • 26 citations

Potential novel targets for Alzheimer pharmacotherapy: I. Secretases

2002 • 24 citations

Benzolactam (BL) enhances sAPP secretion in fibroblasts and in PC12 cells

1999 • 24 citations

Human amyloid-β causes changes in the levels of endothelial protein kinase C and its α isoform in vitro

2002 • 24 citations

Ionic and signal transduction alterations in Alzheimer’s disease

1999 • 21 citations

Restoration of TEA-Induced Calcium Responses in Fibroblasts from Alzheimer's Disease Patients by a PKC Activator

1998 • 12 citations

Protein kinase C: a nexus in the biochemical events that underlie associative learning.

1993 • 12 citations