Pharmacology and clinical experience with bryostatin 1: a novel anticancer drug

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Protein kinase C

1991 • 914 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

The protein kinase C family

1992 • 399 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

1986 • 255 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

Phase I Study of Bryostatin 1: Assessment of Interleukin 6 and Tumor Necrosis Factor Induction In Vivo

1993 • 185 citations

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

1985 • 167 citations

A phase I study of intravenous bryostatin 1 in patients with advanced cancer

1993 • 147 citations

Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity.

1992 • 133 citations

A phase I trial of bryostatin 1 in patients with advanced malignancy using a 24 hour intravenous infusion

1995 • 120 citations

Biology of the protein kinase C family

1989 • 120 citations

Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells

1988 • 119 citations

Phase I study of bryostatin 1 in patients with relapsed non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

1998 • 110 citations

Differential effects of bryostatin 1 and phorbol ester on human breast cancer cell lines.

1992 • 104 citations

Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

1987 • 104 citations

The Vascular Smooth Muscle Type I Angiotensin II Receptor mRNA Is Destabilized by Cyclic AMP-Elevating Agents

1997 • 102 citations

Bryostatin 1, a unique biologic response modifier: anti-leukemic activity in vitro

1990 • 95 citations

Successful treatment of murine melanoma with bryostatin 1.

1991 • 94 citations

A phase II study of bryostatin 1 in metastatic malignant melanoma

1998 • 79 citations

Agents that Down-Regulate or Inhibit Protein Kinase C Circumvent Resistance to 1-β-D-Arabinofuranosylcytosine-Induced Apoptosis in Human Leukemia Cells that Overexpress Bcl-2

1997 • 78 citations

Immunomodulating properties of a novel series of protein kinase C activators. The bryostatins.

1988 • 76 citations

Varied differentiation responses of human leukemias to bryostatin 1.

1989 • 70 citations

Activation of human T lymphocytes by bryostatin.

1988 • 70 citations

Effect of bryostatin 1 on taxol-induced apoptosis and cytotoxicity in human leukemia cells (U937)

1998 • 66 citations

The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF‐7 breast carcinoma cells

1994 • 63 citations

Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts.

1998 • 63 citations

Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells

1989 • 61 citations

Effects of activators of protein kinase C, including bryostatins 1 and 2, on the growth of A549 human lung carcinoma cells

1989 • 58 citations

Activation and growth of murine tumor-specific T-cells which have in vivo activity with bryostatin 1.

1992 • 54 citations

Evidence of a Functional Role for the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1/MDA6in the Reciprocal Regulation of PKC Activator-Induced Apoptosis and Differentation in Human Myelomonocytic Leukemia Cells

1998 • 54 citations

Phase Ib trial of bryostatin 1 in patients with refractory malignancies.

1998 • 51 citations

Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.

1994 • 49 citations

The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma

1995 • 47 citations

In vivo administration of the anticancer agent bryostatin 1 activates platelets and neutrophils and modulates protein kinase C activity.

1993 • 43 citations

Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro

1994 • 42 citations

Bryostatin 1-induced hairy cell features on chronic lymphocytic leukemia cells in vitro.

1993 • 42 citations

Modulation of gene expression in the acute promyelocytic leukemia cell line NB4.

1993 • 41 citations

Successful treatment of human chronic lymphocytic leukemia xenografts with combination biological agents auristatin PE and bryostatin 1.

1998 • 41 citations

The action of bryostatin on normal human hematopoietic progenitors is mediated by accessory cell release of growth factors

1990 • 40 citations

Mitogen-activated Protein Kinase Is Involved in the Degradation of p53 Protein in the Bryostatin-1-induced Differentiation of the Acute Promyelocytic Leukemia NB4 Cell Line

1999 • 37 citations

Protein kinase C activation without membrane contact in platelets stimulated by bryostatin.

1993 • 37 citations

Bryostatin 1, a novel antineoplastic agent and protein kinase C activator, induces human myalgia and muscle metabolic defects: a 31P magnetic resonance spectroscopic study

1995 • 34 citations

The Antineoplastic Agent Bryostatin-1 Induces Proinflammatory Cytokine Production in Human Monocytes: Synergy With Interleukin-2 and Modulation of Interleukin-2Rγ Chain Expression

1997 • 34 citations

Protein kinase C--an enzyme and its relatives.

1994 • 31 citations

Potentiation of 2-Chlorodeoxyadenosine Activity by Bryostatin 1 in the Resistant Chronic Lymphocytic Leukemia Cell Line (WSU-CLL): Association with Increased Ratios of dCK/5'-NT and Bax/Bcl-2

1998 • 31 citations

PKC-independent modulation of multidrug resistance in cells with mutant (V185) but not wild-type (G185) p-glycoprotein by bryostatin 1

1998 • 30 citations

Potential for protein kinase C inhibitors in cancer therapy

1995 • 28 citations

Differential effects of bryostatin 1 on human non-hodgkin's B-lymphoma cell lines

1993 • 28 citations

Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells.

1995 • 26 citations

Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML

1998 • 25 citations

Synergistic interaction of selected marine animal anticancer drugs against human diffuse large cell lymphoma

1998 • 24 citations

Differentiation and Growth Modulation of Myeloid Leukemia Cells by the Protein Kinase C Activating Agent Bryostatin-1

1993 • 24 citations

Effect of protein kinase C inhibitors on invasiveness of human melanoma clones expressing different levels of protein kinase C isoenzymes

1994 • 24 citations

Protein kinase C activators can interact synergistically with granulocyte colony-stimulating factor or interleukin-6 to stimulate colony formation from enriched granulocyte-macrophage colony-forming cells

1993 • 22 citations

Bryostatin 1 modulates the proliferation and lineage commitment of human myeloid progenitor cells exposed to recombinant interleukin-3 and recombinant granulocyte-macrophage colony-stimulating factor

1992 • 22 citations

Effect of the protein kinase C activating agent bryostatin 1 on the clonogenic response of leukemic blast progenitors to recombinant granulocyte-macrophage colony-stimulating factor.

1991 • 22 citations

Bryostatin 1-activated T cells can traffic and mediate tumor regression

1992 • 21 citations

In vivo synergistic effect of the immunomodulator AS101 and the PKC inducer bryostatin

1992 • 19 citations

Bryostatin 1 Activates T Cells That Have Antitumor Activity

1992 • 19 citations

Comparison of effects of growth factors and protein kinase C activators on cellular sensitivity to cis‐diamminedichloroplatinum(II)

1994 • 18 citations

Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro

1998 • 18 citations

Modulation by staurosporine of phorbol‐ester‐induced effects on growth and protein kinase C localization in a549 human lung‐carcinoma cells

1992 • 18 citations

Activation of T-cells by bryostatins: Induction of the IL-2 receptor gene transcription and down-modulation of surface receptors

1990 • 17 citations

Conversion of high grade lymphoma tumor cell line to intermediate grade with tpa and bryostatin 1 as determined by polypeptide analysis on 2D gel electrophoresis

1990 • 17 citations

Modulation of bryostatin 1 muscle toxicity by nifedipine: effects on muscle metabolism and oxygen supply

1996 • 17 citations

Regulation of hematopoiesis-IV: The role of interleukin-3 and bryostatin 1 in the growth of erythropoietic progenitors from normal and anemic W/Wv mice

1988 • 16 citations

Effect of bryostatin 1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM).

1992 • 14 citations

Modulation of ara-C induced apoptosis in leukemia by the PKC activator bryostatin 1

1997 • 13 citations

A sensitive platelet activation-based functional assay for the antileukemic agent bryostatin 1

1995 • 12 citations

Compatibility and stability of bryostatin 1 in infusion devices

1998 • 12 citations

Effects of bryostatin 1 and calcium ionophore (A23187) on apoptosis and differentiation in human myeloid leukemia cells (HL-60) following 1-beta-D-arabinofuranosylcytosine exposure.

1998 • 11 citations

Radiosensitization of HL-60 human leukaemia cells by bryostatin-1 in the absence of increased DNA fragmentation or apoptotic cell death

1996 • 10 citations

High-performance liquid chromatographic assay for the novel antitumor drug, bryostatin-1, incorporating a serum extraction technique

1998 • 9 citations

Induction of Differentiation of B-Cell Leukemia Cell Lines JVM-2 and EHEB bj Bryostatin 1

1993 • 9 citations

Bryostatin 1 acts synergistically with interleukin-1 alpha to induce secretion of G-CSF and other cytokines from marrow stromal cells.

1996 • 9 citations

The Effect of Bryostatin 1 on Human Lymphocyte-Mediated Cytotoxicity

1991 • 8 citations

The Effects of the Macrocyclic Lactone Bryostatin-1 on Leukemic Cells in Vitro

1992 • 7 citations

Role of TNFα in bryostatin-induced inhibition of human hematopoiesis

1999 • 7 citations

Bryostatins trigger human polymorphonuclear neutrophil and monocyte oxidative metabolism: association with in vitro antineoplastic activity

1995 • 7 citations

In vivo stimulation of murine haematopoiesis by the antineoplastic agent bryostatin-1

1990 • 7 citations

Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors

1993 • 6 citations