The biological cost of antibiotic resistance

Inactivation of Antibiotics and the Dissemination of Resistance Genes

1994 • 1,766 citations

Tuberculosis: Commentary on a Reemergent Killer

1992 • 1,400 citations

Epidemiology of Drug Resistance: Implications for a Post—Antimicrobial Era

1992 • 1,325 citations

The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland

1997 • 1,221 citations

The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance

1999 • 780 citations

Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.

1986 • 650 citations

Compensatory Mutations, Antibiotic Resistance and the Population Genetics of Adaptive Evolution in Bacteria

2000 • 620 citations

Antimicrobial agent resistance in mycobacteria: molecular genetic insights

1995 • 601 citations

Effects of Environment on Compensatory Mutations to Ameliorate Costs of Antibiotic Resistance

2000 • 457 citations

Evolution of a bacteria/plasmid association

1988 • 450 citations

Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis

1996 • 422 citations

The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions

2000 • 417 citations

Adaptation to the fitness costs of antibiotic resistance inEscherichia coli

1997 • 411 citations

Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs

1999 • 378 citations

Virulence of antibiotic-resistant Salmonella typhimurium

1998 • 340 citations

The antibiotic paradox: how miracle drugs are destroying the miracle

1993 • 330 citations

Selection in chemostats

1983 • 323 citations

The Population Genetics of Antibiotic Resistance

1997 • 320 citations

Compensatory Evolution in Rifampin-Resistant Escherichia coli

2000 • 267 citations

Survival of rifampin-resistant mutants of Pseudomonas fluorescens and Pseudomonas putida in soil systems

1988 • 260 citations

Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis

1999 • 243 citations

Mechanisms of Bacterial Resistance to Antibiotics

1991 • 213 citations

Impact ofgyrAandparCMutations on Quinolone Resistance, Doubling Time, and Supercoiling Degree ofEscherichia coli

1999 • 201 citations

Studies of antibiotic resistance within the patient, hospitals and the community using simple mathematical models

1999 • 199 citations

Expression of katG in Mycobacterium tuberculosis Is Associated with Its Growth and Persistence in Mice and Guinea Pigs

1998 • 196 citations

The cost of antibiotic resistance from a bacterial perspective

2000 • 173 citations

Effect of Antimicrobial Use and Other Risk Factors on Antimicrobial Resistance in Pneumococci

1997 • 173 citations

Genetic analysis of a plasmid-encoded, host genotype-specific enhancement of bacterial fitness

1994 • 168 citations

Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis

1995 • 166 citations

The Maintenance of Plasmid-containing Organisms in Populations of Escherichia coli

1981 • 163 citations

Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug

1996 • 157 citations

Horizontal Genetic Exchange, Evolution, and Spread of Antibiotic Resistance in Bacteria

1998 • 153 citations

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

1999 • 151 citations

Inactivation of the ampD gene causes semiconstitutive overproduction of the inducible Citrobacter freundii beta-lactamase

1987 • 150 citations

Bacterial fitness and plasmid loss: the importance of culture conditions and plasmid size

1998 • 148 citations

A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci.

1990 • 146 citations

Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis

1997 • 131 citations

Understanding, predicting and controlling the emergence of drug-resistant tuberculosis: a theoretical framework

1998 • 128 citations

Quantifying Fitness and Gene Stability in Microorganisms

1991 • 121 citations

Genetic analyses of sulfonamide resistance and its dissemination in gram-negative bacteria illustrate new aspects of R plasmid evolution

1991 • 116 citations

COEVOLUTION IN BACTERIAL-PLASMID POPULATIONS

1991 • 105 citations

Expression of tetracycline resistance in pBR322 derivatives reduces the reproductive fitness of plasmid-containing Escherichia coli

1985 • 96 citations

Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli

1997 • 83 citations

Clonal Spread of Group A Streptococcus with the New Type of Erythromycin Resistance

1998 • 83 citations

Fitness costs associated with class IIa bacteriocin resistance in Listeria monocytogenes B73

1998 • 81 citations

The Dynamic Structure of EF-G Studied by Fusidic Acid Resistance and Internal Revertants

1996 • 78 citations

General mechanisms of resistance to antibiotics

1988 • 76 citations

Transmission Dynamics of Epidemic Methicillin‐ResistantStaphylococcus aureusand Vancomycin‐Resistant Enterococci in England and Wales

1999 • 72 citations

β-Lactamase Induction in Gram-Negative Bacteria Is Intimately Linked to Peptidoglycan Recycling

1995 • 68 citations

Antimicrobial agent resistance in mycobacteria: molecular genetic insights.

1995 • 57 citations

Epidemiology of emerging/re-emerging antimicrobial-resistant bacterial pathogens

1998 • 51 citations

Mechanisms of bacterial resistance to antibiotics

1991 • 50 citations

Plasmid macro-evolution: selection of deletions during adaptation in a nutrient-limited environment

1991 • 49 citations

Coevolution in Bacterial-Plasmid Populations

1991 • 47 citations

Fusidic acid‐resistant EF‐G perturbs the accumulation of ppGpp

2000 • 46 citations

Antibacterial efflux systems.

1997 • 43 citations

Adaptation of Escherichia coli growth rates to the presence of pBR322

1993 • 32 citations

Overview of mechanisms of bacterial resistance

1989 • 31 citations

Structure and functions of the Bordetella tracheal cytotoxin.

1988 • 24 citations

Conditions for the Existence of R-Plasmids in Bacterial Populations

1980 • 24 citations

Urinary Tract Infection in Primary Health Care in Northern Sweden: III. Bacteriology in Relation to Clinical and Epidemiological Factors

1987 • 13 citations

Einfach-Mendelnde Merkmale

1922 • 1 citations

Deleted Work

1955 • 0 citations