The cost of antibiotic resistance from a bacterial perspective

Escherichia coli and Salmonella :cellular and molecular biology

1996 • 8,124 citations

The Effect of Changes in the Consumption of Macrolide Antibiotics on Erythromycin Resistance in Group A Streptococci in Finland

1997 • 1,221 citations

The biological cost of antibiotic resistance

1999 • 868 citations

High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

1996 • 836 citations

The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance

1999 • 780 citations

Compensatory Mutations, Antibiotic Resistance and the Population Genetics of Adaptive Evolution in Bacteria

2000 • 620 citations

Evaluating treatment protocols to prevent antibiotic resistance

1997 • 495 citations

Effects of Environment on Compensatory Mutations to Ameliorate Costs of Antibiotic Resistance

2000 • 457 citations

Evolution of a bacteria/plasmid association

1988 • 450 citations

Compensatory ahp C Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis

1996 • 422 citations

The epidemiology of antibiotic resistance in hospitals: Paradoxes and prescriptions

2000 • 417 citations

Adaptation to the fitness costs of antibiotic resistance inEscherichia coli

1997 • 411 citations

Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs

1999 • 378 citations

Proliferation of mutators in A cell population

1997 • 342 citations

Virulence of antibiotic-resistant Salmonella typhimurium

1998 • 340 citations

The Population Genetics of Antibiotic Resistance

1997 • 320 citations

Survival of rifampin-resistant mutants of Pseudomonas fluorescens and Pseudomonas putida in soil systems

1988 • 260 citations

Physiological Cost of Rifampin Resistance Induced In Vitro in Mycobacterium tuberculosis

1999 • 243 citations

Studies of antibiotic resistance within the patient, hospitals and the community using simple mathematical models

1999 • 199 citations

Expression of katG in Mycobacterium tuberculosis Is Associated with Its Growth and Persistence in Mice and Guinea Pigs

1998 • 196 citations

The Influence of the Growth Environment on the Stability of a Drug Resistance Plasmid in Escherichia coli K12

1979 • 189 citations

Recombination between short DNA homologies causes tandem duplication

1981 • 184 citations

Evidence That Gene Amplification Underlies Adaptive Mutability of the Bacterial lac Operon

1998 • 184 citations

Effect of Antimicrobial Use and Other Risk Factors on Antimicrobial Resistance in Pneumococci

1997 • 173 citations

Genetic analysis of a plasmid-encoded, host genotype-specific enhancement of bacterial fitness

1994 • 168 citations

Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis

1995 • 166 citations

The Maintenance of Plasmid-containing Organisms in Populations of Escherichia coli

1981 • 163 citations

Characterization of the pleiotropic phenotypes of rifampin-resistant rpoB mutants of Escherichia coli

1989 • 153 citations

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium

1999 • 151 citations

Generation time-prolonging R plasmids: Correlation between increases in the generation time of Escherichia coli caused by R plasmids and their molecular size

1980 • 132 citations

Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis

1997 • 131 citations

Understanding, predicting and controlling the emergence of drug-resistant tuberculosis: a theoretical framework

1998 • 128 citations

Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice

1995 • 123 citations

COEVOLUTION IN BACTERIAL-PLASMID POPULATIONS

1991 • 105 citations

Expression of tetracycline resistance in pBR322 derivatives reduces the reproductive fitness of plasmid-containing Escherichia coli

1985 • 96 citations

AMELIORATION OF THE DELETERIOUS PLEIOTROPIC EFFECTS OF AN ADAPTIVE MUTATION INBACILLUS SUBTILIS

1994 • 94 citations

To be a mutator, or how pathogenic and commensal bacteria can evolve rapidly

1997 • 88 citations

Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis expressed in a knockout mutant of Escherichia coli

1997 • 83 citations

Fitness costs associated with class IIa bacteriocin resistance in Listeria monocytogenes B73

1998 • 81 citations

The Dynamic Structure of EF-G Studied by Fusidic Acid Resistance and Internal Revertants

1996 • 78 citations

Plasmid expression and maintenance during long-term starvation-survival of bacteria in well water

1989 • 61 citations

Development of -Lactamase-Mediated Resistance to Penicillin in Middle-Ear Isolates of Moraxella catarrhalis in Finnish Children, 1978-1993

1995 • 54 citations

Epidemiology of emerging/re-emerging antimicrobial-resistant bacterial pathogens

1998 • 51 citations

Plasmid macro-evolution: selection of deletions during adaptation in a nutrient-limited environment

1991 • 49 citations

Coevolution in Bacterial-Plasmid Populations

1991 • 47 citations

Amelioration of the Deleterious Pleiotropic Effects of an Adaptive Mutation in Bacillus subtilis

1994 • 37 citations

Genetic changes accompanying increased fitness in evolving populations of Escherichia coli.

1992 • 34 citations

Adaptation of Escherichia coli growth rates to the presence of pBR322

1993 • 32 citations

Parameters affecting plasmid stability in Bacillus subtilis

1991 • 30 citations

E. coliGrowth Inhibition by a High Copy Number Derivative of Plasmid pBR322

1996 • 24 citations

Conditions for the Existence of R-Plasmids in Bacterial Populations

1980 • 24 citations