Lupus Susceptibility Genes on Human Chromosome 1

Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

1993 • 3,693 citations

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER

1997 • 1,730 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

1996 • 794 citations

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

1997 • 698 citations

Antibodies to DNA

1998 • 672 citations

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.

1997 • 661 citations

Uncoupling of Immune Complex Formation and Kidney Damage in Autoimmune Glomerulonephritis

1998 • 621 citations

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases

1998 • 601 citations

Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.

1995 • 542 citations

Interleukin 10 secretion in relation to human IL-10 locus haplotypes

1998 • 478 citations

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

1996 • 476 citations

Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

1998 • 458 citations

Detecting Marker-Disease Association by Testing for Hardy-Weinberg Disequilibrium at a Marker Locus

1998 • 369 citations

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families

1998 • 362 citations

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

1998 • 340 citations

Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.

1998 • 336 citations

Genome-Wide Screen for Systemic Lupus Erythematosus Susceptibility Genes in Multiplex Families

1999 • 319 citations

Complement deficiency and disease

1991 • 316 citations

GENETIC SUSCEPTIBILITY TO SYSTEMIC LUPUS ERYTHEMATOSUS

1998 • 313 citations

Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin-10: Interferon-γ–secreting cells in the peripheral blood

1996 • 292 citations

Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.

1997 • 279 citations

Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus

1998 • 250 citations

Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus.

1997 • 242 citations

Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.

1990 • 232 citations

Skewed distribution of IGG FC receptor iia (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients

1995 • 213 citations

TCR zeta chain lacking exon 7 in two patients with systemic lupus erythematosus

1998 • 209 citations

Association between polymorphisms at the human IL‐10 locus and systemic lupus erythematosus

1997 • 176 citations

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

1994 • 174 citations

Synergistic effect betweenIL-10 andbcl-2 genotypes in determining susceptibility to systemic lupus erythematosus

1998 • 159 citations

Dysregulation of interleukin‐10 production in relatives of patients with systemic lupus erythematosus

1997 • 132 citations

Genetic susceptibility to Alzheimer disease

1995 • 128 citations

Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus

1999 • 126 citations

Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese

1999 • 117 citations

TFc?RIIIA-158F allele is a risk factor for systemic lupus erythematosus

1998 • 116 citations

FcγRIIa polymorphism in systemic lupus erythematosus (SLE): no association with disease

1996 • 112 citations

PARP alleles within the linked chromosomal region are associated with systemic lupus erythematosus

1999 • 110 citations

Fc? receptor IIa polymorphism in caucasian patients with systemic lupus erythematosus: Association with clinical symptoms

1998 • 103 citations

Antibody reactivity to the hres‐1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes

1995 • 99 citations

Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles

1997 • 96 citations

Apoptosis in the rheumatic diseases

1997 • 94 citations

Abnormal distribution of Fc? receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus

1998 • 94 citations

Overrepresentation of the Fc? receptor type IIA R131/R131 genotype in Caucasoid systemic lupus erythematosus patients with autoantibodies to C1q and glomerulonephritis

1999 • 94 citations

An abnormality of the gene that encodes neutrophil Fc receptor III in a patient with systemic lupus erythematosus.

1990 • 87 citations

Confirmation of genetic linkage between human systemic lupus erythematosus and chromosome 1q41

1999 • 78 citations

Increased number of interleukin-10-producing cells in systemic lupus erythematosus patients and their first-degree relatives and spouses in Icelandic multicase families

1999 • 67 citations

Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease.

1997 • 65 citations

Altered distribution of Fc? receptor IIIA alleles in a cohort of Korean patients with lupus nephritis

1999 • 62 citations

Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus correlate with systemic lupus erythematosus and autoreactivity

1999 • 56 citations

Mapping of a gene for hypergammaglobulinemia to the distal region on chromosome 4 in NZB mice and its contribution to systemic lupus erythematosus in (NZB×NZW)F₁ mice

1994 • 56 citations

Mutations in T cell Receptor ζ Chain mRNA of Peripheral T cells from Systemic Lupus Erythematosus Patients

1998 • 55 citations

Dubois' Lupus Erythematosus, 6th ed

2003 • 54 citations

Poly(ADP-ribose) polymerase alleles in French Caucasians are associated neither with lupus nor with primary antiphospholipid syndrome

1999 • 33 citations

Single-nucleotide polymorphisms of T cell receptor ? chain in patients with systemic lupus erythematosus

1999 • 31 citations

Molecular basis of IgG Fc receptor III defect in a patient with systemic lupus erythematosus

1991 • 30 citations

Altered metabolism of poly(adp‐ribose) in the peripheral blood lymphocytes of patients with systemic lupus erythematosus

1989 • 28 citations

Decreased mRNA Levels Coding for Poly(ADP-Ribose) Polymerase in Lymphocytes of Patients with SLE

1994 • 19 citations

Duboisʼ Lupus Erythematosus, 6th Edition

2002 • 8 citations

Tolerance abnormalities in systemic lupus erythematosus

1993 • 1 citations