How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity?

The hazard of accelerated tumor clonogen repopulation during radiotherapy

1988 • 1,592 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

[Fractionation in radiotherapy].

1972 • 487 citations

Fractionation in Radiotherapy

1988 • 345 citations

Survey of radiosensitivity in a variety of human cell strains.

1980 • 271 citations

Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx

1990 • 239 citations

Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury.

1994 • 220 citations

X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders.

1980 • 201 citations

Evidence for individual differences in the radiosensitivity of human skin

1992 • 193 citations

Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients

1993 • 186 citations

Dose and volume effects on fibrosis after breast conservation therapy

1994 • 162 citations

Prediction of normal-tissue tolerance to radiotherapy from in-vitro cellular radiation sensitivity

1992 • 161 citations

Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer

1995 • 137 citations

Alpha/beta value and the importance of size of dose per fraction for late complications in the supraglottic larynx

1986 • 132 citations

The ESTRO Regaud lecture Inherent radio sensitivity of tumor and normal tissue cells as a predictor of human tumor response

1990 • 129 citations

Evidence for a Positive Correlation betweenin VitroRadiosensitivity of Normal Human Skin Fibroblasts and the Occurrence of Subcutaneous Fibrosis after Radiotherapy

1994 • 125 citations

Comparative Human Cellular Radiosensitivity: II. The Survival Following Gamma-irradiation of Unstimulated (G₀) T-lymphocytes, T-lymphocyte Lines, Lymphoblastoid Cell Lines and Fibroblasts from Normal Donors, from Ataxia-telangiectasia Patients and from Ataxia-telangiectasia Heterozygotes

1988 • 114 citations

Clinical correlations between late normal tissue endpoints after radiotherapy: Implications for predictive assays of radiosensitivity

1993 • 111 citations

Re-evaluation ofin VitroRadiosensitivity of Human Fibroblasts of Different Genetic Origins

1986 • 109 citations

An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia

1990 • 108 citations

Dose, time, and fraction size issues for late effects in head and neck cancers

1992 • 94 citations

Radiotherapeutic management of medulloblastoma in a pediatric patient with ataxia telangiectasia

1987 • 91 citations

The Importance of Genetics for the Optimization of Radiation Therapy A Hypothesis

1988 • 90 citations

Radiosensitivity in Cultured Human Fibroblasts

1980 • 83 citations

Lack of Correlation of Human Fibroblast Radiosensitivityin Vitrowith Early Skin Reactions in Patients Undergoing Radiotherapy

1993 • 82 citations

In Vitro Radiosensitivity of Human Diploid Fibroblasts Derived from Women with Unusually Sensitive Clinical Responses to Definitive Radiation Therapy for Breast Cancer

1990 • 82 citations

Ataxia telangiectasia with cancer. An indication for reduced radiotherapy and chemotherapy doses

1983 • 69 citations

Hyperfractionated radiotherapy in the treatment of squamous cell carcinomas of the supraglottic larynx

1989 • 67 citations

Radiosensitivity in vitro of human fibroblasts derived from patients with a severe skin reaction to radiation therapy

1980 • 50 citations

Sensitivity of Human Diploid Fibroblast Cell Strains from Various Genetic Disorders to Acute and Protracted Radiation Exposure

1990 • 48 citations

Sensitivity of cultured cells to gamma radiation in a patient exhibiting marked in vivo radiation sensitivity

1988 • 39 citations