Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders.

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Geographical relation between Alzheimer's disease and aluminum in drinking water.

1989 • 600 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Limits of Neurogenesis in Primates

1985 • 486 citations

Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

1987 • 472 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

Dementia of the Alzheimer Type

1981 • 451 citations

Metabolism and possible health effects of aluminum.

1986 • 440 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

1988 • 386 citations

Risk factors for clinically diagnosed Alzheimer's disease

1986 • 365 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

1989 • 345 citations

Pathological changes in olfactory neurons in patients with Alzheimer's disease

1989 • 310 citations

PRESENILE DEMENTIA AND ALZHEIMER'S DISEASE IN MONGOLISM

1969 • 292 citations

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

1987 • 275 citations

PREDISPOSING LOCUS FOR ALZHEIMER'S DISEASE ON CHROMOSOME 21

1989 • 271 citations

The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein gene

1987 • 271 citations

Alzheimer's disease: Genetic aspects and associated clinical disorders

1983 • 269 citations

MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE

1989 • 266 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

Rapid detection of human chromosome 21 aberrations by in situ hybridization.

1988 • 251 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Chromosome Segregation in Mitosis and Meiosis

1985 • 193 citations

Human amyloidosis, Alzheimer disease and related disorders.

1988 • 177 citations

Differential regulation of amyloid-beta-protein mRNA expression within hippocampal neuronal subpopulations in Alzheimer disease.

1988 • 176 citations

Familial Alzheimer's disease

1963 • 156 citations

Dementia of the Alzheimer type

1987 • 143 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

Case‐control study of late onset “probable Alzheimer's disease”

1987 • 130 citations

The Genetics of Alzheimer's Disease

1977 • 116 citations

A Study of Familial Factors in Alzheimer's Disease

1982 • 101 citations

Premature centromere division: A mechanism of non‐disjunction causing X chromosome aneuploidy in somatic cells of man

1975 • 94 citations

Alterations in the adenine-plus-thymine-rich region of CEN3 affect centromere function in Saccharomyces cerevisiae.

1987 • 92 citations

Regional location of α1-antichymotrypsin and α1-antitrypsin genes on human chromosome 14

1986 • 92 citations

Hypothesis: microtubules, a key to Alzheimer disease.

1989 • 91 citations

People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.

1989 • 73 citations

Abnormal skin fibroblast cytogenetics in four dysmorphic patients with normal lymphocyte chromosomes.

1979 • 72 citations

α1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits

1989 • 70 citations

Hyper-Reactivity to Atropine in Down's Syndrome

1968 • 68 citations

Chromosome studies of patients with Alzheimer disease

1983 • 66 citations

Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology.

1991 • 62 citations

Increased aneuploidy in Alzheimer disease

1979 • 60 citations

Cytogenetic studies of familial and sporadic Alzheimer disease

1981 • 57 citations

Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD)

1986 • 55 citations

Roberts syndrome and SC phocomelia. A single genetic entity

1987 • 53 citations

Alzheimer disease: evidence for susceptibility loci on chromosomes 6 and 14.

1983 • 52 citations

ATROPINE IN MONGOLISM

1959 • 52 citations

Metaphase and anaphase analysis of V79 cells exposed to erionite, UICC chrysotile and UICC crocidolite

1987 • 50 citations

A Possible Unitary Genetic Hypothesis for Alzheimer's Disease and Down Syndromea

1985 • 46 citations

Chromosome changes in Alzheimer's presenile dementia.

1983 • 44 citations

An efficient method for selecting unique-sequence clones from DNA libraries and its application to fluorescent staining of human chromosome 21 using in situ hybridization

1989 • 41 citations

Premature centromere division (PCD): a dominantly inherited cytogenetic anomaly

1987 • 40 citations

Chromosome aberrations induced in vitro by low doses of radiation: nondisjunction in lymphocytes of young adults.

1975 • 31 citations

Alterations in the Adenine-plus-Thymine-Rich Region of CEN3 Affect Centromere Function in Saccharomyces cerevisiae

1987 • 30 citations

Chromosomes and Mental Status

1974 • 16 citations

Centromere separation and aneuploidy in human mitotic mutants: Roberts syndrome.

1989 • 8 citations

Linkage studies of late-onset familial Alzheimer's disease.

1990 • 7 citations