Gabaergic and dopaminergic transmission in the rat cerebral cortex: Effect of stress, anxiolytic and anxiogenic drugs

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Handbook of Psychopharmacology

1988 • 2,778 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

Chemical Neuroanatomy

1984 • 1,646 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

Selective antagonists of benzodiazepines

1981 • 1,235 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

Stress in Health and Disease

1976 • 972 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

Type I and Type II GABA _A -Benzodiazepine Receptors Produced in Transfected Cells

1989 • 716 citations

Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat

1971 • 685 citations

Electrophysiology of GABAA and GABAB receptor subtypes

1988 • 645 citations

Molecular Mechanisms in the Receptor Action of Benzodiazepines

1979 • 579 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1982 • 549 citations

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

1983 • 544 citations

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

1986 • 543 citations

The dopamine hypothesis of schizophrenia: focus on the dopamine receptor

1976 • 543 citations

Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors.

1980 • 542 citations

Two novel GABAA receptor subunits exist in distinct neuronal subpopulations

1989 • 532 citations

Brain Microdialysis

1989 • 518 citations

Dopaminergic Terminals in the Rat Cortex

1973 • 502 citations

Pharmacology of mesocortical dopamine neurons.

1983 • 478 citations

Mechanism of Action of Benzodiazepines

1976 • 437 citations

Differential effects of inescapable footshocks and of stimuli previously paired with inescapable footshocks on dopamine turnover in cortical and limbic areas of the rat

1982 • 424 citations

Neuropsychopharmacology of monoamines and their regulatory enzymes.

1974 • 416 citations

EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM¹

1969 • 394 citations

Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties.

1987 • 368 citations

Footshock and conditioned stress increase 3, 4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra

1985 • 355 citations

Possible involvement of GABA in the central actions of benzodiazepines.

1975 • 346 citations

Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat

1979 • 328 citations

Ethanol Specifically Potentiates GABA-Mediated Neurotransmission in Feline Cerebral Cortex

1980 • 322 citations

Benzodiazepine Receptor-Mediated Experimental "Anxiety" in Primates

1982 • 314 citations

Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-gaba receptor-ionophore complex

1984 • 298 citations

Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

1978 • 291 citations

Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep mice

1986 • 280 citations

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1984 • 279 citations

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.

1986 • 274 citations

Functional Coupling of γ-Aminobutyric Acid Receptors to Chloride Channels in Brain Membranes

1985 • 270 citations

Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels

1987 • 264 citations

The anxiogenic action of benzodiazepine antagonists

1982 • 263 citations

Benzodiazepine/GABA receptors and chloride channels : structural and functional properties

1986 • 260 citations

Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurones

1977 • 254 citations

Benzodiazepine receptor ligands with positive and negative efficacy

1983 • 244 citations

Benzodiazepine recognition site ligands: biochemistry and pharmacology.

1983 • 244 citations

Ethyl β-carboline carboxylate lowers seizure threshold and antagonizes flurazepam-induced sedation in rats

1981 • 225 citations

beta-Carbolines enhance shock-induced suppression of drinking in rats.

1983 • 217 citations

Binding of [3H]alpha-dihydropicrotoxinin, a gamma-aminobutyric acid synaptic antagonist, to rat brain membranes.

1978 • 216 citations

Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function.

1988 • 211 citations

Stress-induced enhancement of dopamine and acetylcholine release in limbic structures: role of corticosterone

1989 • 211 citations

Convulsant potencies of tetrazoles are highly correlated with actions on GABA/benzodiazepine/picrotoxin receptor complexes in brain

1984 • 192 citations

Stress in Health and Disease.

1977 • 191 citations

Diazepam enhancement of low affinity GABA binding to rat brain membranes

1982 • 166 citations

Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat.

1986 • 165 citations

Anxiogenic and non-anxiogenic benzodiazepine antagonists

1983 • 165 citations

GABAergic transmission and anxiety

1986 • 161 citations

Ligands for benzodiazepine receptors with positive and negative efficacy

1984 • 157 citations

Binding Characteristics and Interactions of Depressant Drugs with [³⁵S]t-Butylbicyclophosphorothionate, a Ligand that Binds to the Picrotoxinin Site

1984 • 156 citations

Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus

1976 • 155 citations

Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?

1985 • 155 citations

Evaluation of the ?-carboline ZK 93 426 as a benzodiazepine receptor antagonist

1984 • 154 citations

Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy

1989 • 153 citations

Imidazopyridines as a tool for the characterization of benzodiazepine receptors: A proposal for a pharmacological classification as omega receptor subtypes

1988 • 146 citations

Stress‐Related Changes in Cerebral Catecholamine and Indoleamine Metabolism: Lack of Effect of Adrenalectomy and Corticosterone

1988 • 145 citations

Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.

1975 • 141 citations

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

1984 • 136 citations

Decrease in the Function of the γ‐Aminobutyric Acid‐Coupled Chloride Channel Produced by the Repeated Administration of Pentylenetetrazol to Rats

1990 • 134 citations

Chloride channels and their modulation by neurotransmitters and drugs.

1988 • 134 citations

The effects of naloxone and picrotoxin on the sedative and anticonflict effects of benzodiazepines

1978 • 124 citations

Modulation of neurotransmitter action: control of the gamma- aminobutyric acid response through the benzodiazepine receptor

1985 • 121 citations

The effects of footshock stress on regional brain dopamine metabolism and pituitary β-endorphin release in rats previously sensitized to amphetamine

1987 • 120 citations

Neurochemical Responses in Stress: Relationships Between the Hypothalamic-Pituitary-Adrenal and Catecholamine Systems

1984 • 119 citations

Enhancement of GABA binding by benzodiazepines and related anxiolytics

1983 • 118 citations

Rapid changes in GABA binding induced by stress in different areas of the rat brain

1981 • 115 citations

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

1987 • 113 citations

Proconflict effect of benzodiazepine receptor inverse agonists and other inhibitors of GABA function

1984 • 109 citations

ZK 91296, a partial agonist at benzodiazepine receptors

1984 • 107 citations

[35S]-t-butylbicyclophosphorothionate binding sites are constituents of the gamma-aminobutyric acid benzodiazepine receptor complex

1984 • 106 citations

Molecular substrates of anxiety: Clues from the heterogeneity of benzodiazepine receptors

1982 • 105 citations

Selective increase in dopamine metabolism in the prefrontal cortex by the anxiogenic beta-carboline FG 7142

1985 • 101 citations

Stress and β-carbolines decrease the density of low affinity gaba binding sites

1984 • 100 citations

Tolerance to the anticonvulsant effect of benzodiazepines

1988 • 96 citations

Structure-toxicity relationships of 2,6,7-trioxabicyclo[2.2.2]-octanes and related compounds

1976 • 94 citations

Discriminative stimulus properties of ?-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors

1984 • 94 citations

γ-Aminobutyric acid activation of36Cl-flux in rat hippocampal slices and its potentiation by barbiturates

1984 • 94 citations

Metrazol tolerance in a “normal” volunteer population

1958 • 91 citations

GABA receptors induced in Xenopus oocytes by chick brain mRNA: evaluation of TBPS as a use-dependent channel-blocker

1987 • 89 citations

The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

1986 • 86 citations

Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity

1985 • 86 citations

Benzodiazepine Enhancement of γ‐Aminobutyric Acid‐Mediated Chloride Ion Flux in Rat Brain Synaptoneurosomes

1988 • 86 citations

Neuropeptide modulation of GABA receptor Cl− channels

1985 • 83 citations

Acute, stress-induced changes in the benzodiazepine/gamma-aminobutyric acid receptor complex are confined to the chloride ionophore.

1986 • 82 citations

?-Carbolines can enhance or antagonize the effects of punishment in mice

1985 • 82 citations

Foot‐Shock Stress and Anxiogenic β‐Carbolines Increase t‐[³⁵S]Butylbicyclophosphorothionate Binding in the Rat Cerebral Cortex, an Effect Opposite to Anxiolytics and γ‐Aminobutyric Acid Mimetics

1988 • 81 citations

METRAZOL TOLERANCE IN A “NORMAL” VOLUNTEER POPULATION

1970 • 80 citations

Barbiturate and picrotoxin‐sensitive chloride efflux in rat cerebral cortical synaptoneurosomes

1984 • 80 citations

Benzodiazepines: behavioral and neurochemical mechanisms

1977 • 80 citations

Development of tolerance to the anticonvulsant effect of diazepam in dogs

1984 • 79 citations

Modulation of the chloride ionophore by benzodiazepine receptor ligands: influence of gamma-aminobutyric acid and ligand efficacy.

1986 • 77 citations

Tolerance to the anticonvulsant action of benzodiazepines

1985 • 77 citations

On the measurement in rats of the convulsant effect of drugs and the changes which follow electroconvulsive shock

1980 • 75 citations

GABAergic synapses supramolecular organization and biochemical regulation

1983 • 75 citations

gamma-Aminobutyric acid-gated chloride channels in cultured cerebral neurons.

1984 • 74 citations

Methyl-β-carboline-induced convulsions are antagonized by Ro 15-1788 and by propyl-β-carboline

1982 • 71 citations

Potentiation by intraventricular muscimol of the anticonflict effect of benzodiazepines

1980 • 70 citations

Depression of benzodiazepine binding and diazepam potentiation of GABA-mediated inhibition after chronic exposure of spinal cord cultures to diazepam

1983 • 68 citations

Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.

1986 • 66 citations

Effect of corticosterone on the synthesis of [3H]catecholamines in the brains of CD-1 mice

1977 • 63 citations

The formation of deaminated metabolites of dopamine in the locus coeruleus depends upon noradrenergic neuronal activity

1985 • 55 citations

Stimulatory and protective effects of benzodiazepines on GABA receptors labeled with [3H]muscimol

1982 • 55 citations

Proconflict effect of GABA receptor complex antagonists

1986 • 54 citations

Changes in GABAergic transmission induced by stress, anxiogenic and anxiolytic β-carbolines

1987 • 52 citations

THE CONVULSANT ACTION OF HYDRAZIDES AND REGIONAL CHANGES IN CEREBRAL ?-AMINOBUTYRIC ACID AND PYRIDOXAL PHOSPHATE CONCENTRATIONS

1979 • 52 citations

Further evidence for GABA-ergic mechanisms in the action of benzodiazepines.

1977 • 48 citations

Chronic administration of diazepam to rats causes changes in EEG patterns and in coupling between GABA receptors and benzodiazepine binding sites in vitro

1984 • 48 citations

Effects of alterations in impulse flow on transmitter metabolism in central dopaminergic neurons.

1974 • 46 citations

The action of stress, beta-carbolines, diazepam, and Ro 15-1788 on GABA receptors in the rat brain.

1983 • 43 citations

Anticonvulsant action in the photosensitive baboon, Papio papio, of a novel β-carboline derivative, ZK 91296

1983 • 43 citations

Enhancement of GABAergic transmission by zolpidem, an imidazopyridine with preferential affinity for type I benzodiazepine receptors

1989 • 42 citations

Kindling and withdrawal changes at the benzodiazepine receptor

1987 • 41 citations

Foot shock stress decreases chloride efflux from rat brain synaptoneurosomes

1987 • 40 citations

Anxiety-like subjective effect of ethanol antagonist Ro 15-4513 demonstrated in pentylenetetrazol discrimination

1987 • 38 citations

Stress‐Induced Changes in t‐[³⁵S]Butylbicyclophosphorothionate Binding to γ‐Aminobutyric Acid‐Gated Chloride Channels Are Mimicked by In Vitro Occupation of Benzodiazepine Receptors

1987 • 38 citations

Relationship of γ-aminobutyric acid (GABA) to antianxiety effects of benzodiazepines

1980 • 38 citations

Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat

1989 • 36 citations

Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling.

1986 • 36 citations

Stress and GABAergic transmission: biochemical and behavioural studies.

1986 • 36 citations

Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms

1987 • 36 citations

Behavioral measurement of benzodiazepine tolerance and GABAergic subsensitivity in the substantia nigra pars reticulata

1988 • 35 citations

Interaction of t‐Butylbicyclophosphorothionate with γ‐Aminobutyric Acid‐Gated Chloride Channels in Cultured Cerebral Neurons

1986 • 33 citations

Tolerance to anti-pentylenetetrazol effects following chronic diazepam

1986 • 32 citations

gamma-Aminobutyric acid receptor-regulated 36Cl- flux in mouse cortical slices.

1987 • 32 citations

Enhanced sensitivity to β-carboline inverse agonists in rats chronically treated with FG 7142

1987 • 30 citations

Benzodiazepine and β-carboline modulation of GABA-stimulated 36Cl-influx in cultured spinal cord neurons

1987 • 29 citations

Involvement of benzodiazepine recognition sites in the foot shock-induced decrease of low affinity GABA receptors in the rat cerebral cortex

1985 • 28 citations

The role of GABA in the anticonflict action of sodium valproate and chlordiazepoxide

1984 • 28 citations

Anxiolytic cyclopyrrolone drugs allosterically modulate the binding of [35S]t-butylbicyclophosphorothionate to the benzodiazepine/gamma-aminobutyric acid-A receptor/chloride anionophore complex.

1984 • 28 citations

Long-lasting proconflict effect induced by chronic administration of the β-carboline derivative FG 7142

1985 • 25 citations

Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.

1984 • 25 citations

Isoniazid, an inhibitor of GABAergic transmission, enhances [35S]TBPS binding in rat cerebral cortex

1989 • 25 citations

Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142

1987 • 25 citations

The effects of drugs acting at the GABA_A‐receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142

1986 • 24 citations

Behavioral and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142

1986 • 24 citations

Ethyl-β-carboline-3-carboxylate decreases [3H]GABA binding in membrane preparations of rat cerebral cortex

1983 • 23 citations

In Vivo Administration of Ethanol Enhances the Function of the γ‐Aminobutyric Acid‐Dependent Chloride Channel in the Rat Cerebral Cortex

1990 • 21 citations

Evidence for an involvement of GABA receptors in the mediation of the proconvulsant action of ethyl-β-carboline-3-carboxylate

1984 • 20 citations

Ro 15-4513, like anxiogenic β-carbolines, increases dopamine metabolism in the prefrontal cortex of the rat

1988 • 20 citations

The anxiolytic β-carboline ZK 93423 prevents the stress-induced increase in dopamine turnover in the prefrontal cortex

1987 • 20 citations

Chronic treatment with diazepam or the inverse benzodiazepine receptor agonist FG 7142 causes differential changes in the effects of GABA receptor stimulation

1988 • 20 citations

Modulation of GABA-stimulated chloride influx by β-carbolines in rat brain membrane vesicles

1988 • 20 citations

Evaluation of the muscle relaxant properties of a novel β‐carboline, ZK 93423 in rats and cats

1985 • 20 citations

Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by triazolobenzodiazepines

1988 • 19 citations

Foot-shock stress enhances the increase of [35S]TBPS binding in the rat cerebral cortex and the convulsions induced by isoniazid

1991 • 19 citations

Enhancement of γ‐Aminobutyric Acid Binding by Quazepam, a Benzodiazepine Derivative with Preferential Affinity for Type I Benzodiazepine Receptors

1986 • 18 citations

Sudden decrease in cerebellar GABA binding induced by stress

1980 • 16 citations

Neurotransmitters in Epilepsy

1988 • 14 citations

Increase of cyclic GMP in cerebellum by methyl-6, 7-dimethoxy-4-ethyl-β-carboline-3-car☐ylate (DMCM)

1983 • 14 citations

Behavioral and EEG effects of benzodiazepines and their antagonists in the cat.

1983 • 14 citations

Structural basis of the GABA-activated chloride channel: molecular biology and molecular electrophysiology.

1988 • 13 citations

Modulation of GABA-stimulated chloride influx into membrane vesicles from rat cerebral cortex by benzodiazepines and nonbenzodiazepines.

1988 • 13 citations

Changes of 36Cl- flux and 35S-TBPS binding induced by stress and gabaergic drugs.

1988 • 13 citations

The β-carboline ZK 93423 inhibits reticulata neurons: An effect reversed by benzodiazepine antagonists

1987 • 10 citations

Dramatic increase in nigral t-[35S]butylbicyclophosphorothionate binding sites elicited by the degeneration of the striato-nigral GABAergic pathway: reversal by diazepam

1989 • 10 citations

Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142.

1988 • 10 citations

Decrease in [3H]flunitrazepam receptor binding in rats tolerant to the effects of nitrazepam

1988 • 10 citations

Enhancement of γ‐Aminobutyric Acid Binding by the Anxiolytic β‐Carbolines ZK 93423 and ZK 91296

1987 • 8 citations

Diazepam enhances bicuculline-induced increase of binding in unwashed membrane preparations from rat cerebral cortex

1990 • 7 citations

Decreased sensitivity to diazepam induced by chronic administration of FG 7142

1988 • 6 citations

Chronic treatment with FG 7142 reduces the function of the GABA-A receptor-coupled chloride ionophore in rats

1988 • 5 citations

Chloride channel modulation through the benzodiazepine recognition site.

1988 • 3 citations