Chronic treatment with lorazepam and FG 7142 may change the effects of benzodiazepine receptor agonists, antagonists and inverse agonists by different mechanisms

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

1983 • 544 citations

Chronic benzodiazepine treatment decreases postsynaptic GABA sensitivity

1984 • 279 citations

Acute and chronic effects of the benzodiazepine receptor ligand FG 7142: proconvulsant properties and kindling

1984 • 136 citations

Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding

1981 • 133 citations

Chronic clonazepam administration induced benzodiazepine receptor subsensitivity

1982 • 91 citations

Decreased 3H-diazepam binding is a specific response to chronic benzodiazepine treatment

1979 • 87 citations

Evidence that tolerance develops to the anxiolytic effect of diazepam in rats

1985 • 86 citations

Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity

1985 • 86 citations

Experimental induction of benzodiazepine tolerance and physical dependence.

1983 • 85 citations

A comparative study of certain pharmacologic responses following acute and chronic administrations of chlordiazepoxide

1967 • 82 citations

Development of tolerance to the anticonvulsant effect of diazepam in dogs

1984 • 79 citations

Studies on the post-ictal rise in seizure threshold

1981 • 76 citations

Reduced diazepam binding following chronic benzodiazepine treatment

1978 • 73 citations

Depression of benzodiazepine binding and diazepam potentiation of GABA-mediated inhibition after chronic exposure of spinal cord cultures to diazepam

1983 • 68 citations

Differences between the tolerance characteristics of two anticonvulsant benzodiazepines

1985 • 66 citations

Spontaneous and Ro 15-1788-induced reversal of subsensitivity to GABA following chronic benzodiapines

1985 • 61 citations

Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse

1983 • 60 citations

Radioreceptor assay for benzodiazepines in biological fluids using a new dry and stable receptor preparation

1981 • 58 citations

Profile of acute tolerance to three sedative anxiolytics

1983 • 56 citations

Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines

1977 • 50 citations

Alterations in a low affinity GABA recognition site following chronic benzodiazepine treatment

1984 • 50 citations

Chronic administration of diazepam to rats causes changes in EEG patterns and in coupling between GABA receptors and benzodiazepine binding sites in vitro

1984 • 48 citations

Functional tolerance to lorazepam in the rat

1983 • 47 citations

Chronic benzodiazepine treatment increases [3H]muscimol binding in mouse brain

1982 • 43 citations

Modulation of Neuronal Function through Benzodiazepine Receptors: Biochemical and Electrophysiological Studies of Neurons in Primary Monolayer Cell Culture

1984 • 43 citations

Benzodiazepine - specific and nonspecific tolerance following chronic flurazepam treatment

1983 • 36 citations

Tolerance and Dependence

1985 • 30 citations

Long-lasting single-dose tolerance to neurologic deficits induced by diazepam

1984 • 26 citations

Selective changes in the in vivo effects of benzodiazepine receptor ligands after chemical kindling with FG 7142

1987 • 25 citations

Lack of tolerance development to benzodiazepines in antagonism of the pentylenetetrazol discriminative stimulus

1979 • 23 citations

Cerebellar cyclic GMP and behavioral effects after acute and repeated administration of benzodiazepines in mice

1982 • 14 citations

Benzodiazepine receptor binding by membranes from brain cell cultures following chronic treatment with diazepam

1983 • 8 citations

Functional tolerance to alprazolam-induced neurologic deficits in mice

1984 • 7 citations