Molecular Basis for Substrate Specificity of Protein-tyrosine Phosphatase 1B

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate

1997 • 811 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

From Form to Function: Signaling by Protein Tyrosine Phosphatases

1996 • 526 citations

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

1994 • 392 citations

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: A paradigm for inhibitor design

1997 • 392 citations

The PTPase YopH inhibits uptake ofYersinia, tyrosine phosphorylation of p130^Casand FAK, and the associated accumulation of these proteins in peripheral focal adhesions

1997 • 373 citations

Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions

1997 • 366 citations

Crystal Structure of the Dual Specificity Protein Phosphatase VHR

1996 • 340 citations

Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130Cas

1996 • 272 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

Identification of p130^cas as a Substrate for the Cytosolic Protein Tyrosine Phosphatase PTP-PEST

1996 • 263 citations

Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis

1998 • 261 citations

Dissecting the catalytic mechanism of protein-tyrosinephosphatases.

1994 • 255 citations

Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography

1998 • 233 citations

Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.

1992 • 228 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Crystal Structure of Bovine Low Molecular Weight Phosphotyrosyl Phosphatase Complexed with the Transition State Analog Vanadate^,

1997 • 199 citations

Substrate specificity of the protein tyrosine phosphatases.

1993 • 189 citations

Protein Tyrosine Phosphatase Substrate Specificity: Size and Phosphotyrosine Positioning Requirements in Peptide Substrates

1994 • 171 citations

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction

1995 • 134 citations

Pre-steady-state and steady-state kinetic analysis of the low molecular weight phosphotyrosyl protein phosphatase from bovine heart

1991 • 120 citations

A Continuous Spectrophotometric and Fluorometric Assay for Protein Tyrosine Phosphatase Using Phosphotyrosine-Containing Peptides

1993 • 117 citations

A ligand-induced conformational change in theyersiniaprotein tyrosine phosphatase

1995 • 112 citations

Kinetic and Mechanistic Characterization of a Mammalian Protein-tyrosine Phosphatase, PTP1

1995 • 89 citations

Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTPβ, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors

1993 • 72 citations

Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an E. coli expression system

1991 • 67 citations

Comparative Kinetic Analysis and Substrate Specificity of the Tandem Catalytic Domains of the Receptor-like Protein-tyrosine Phosphatase α

1997 • 61 citations

Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction

1998 • 59 citations

Rapid Loop Dynamics of Yersinia Protein Tyrosine Phosphatases

1997 • 58 citations

Specificity of T‐cell protein tyrosine phosphatase toward phosphorylated synthetic peptides

1993 • 55 citations

Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1

1993 • 43 citations

Comparison of the Specificity of Bacterially Expressed Cytoplasmic Protein‐Tyrosine Phosphatases SHP and SH‐PTP2 Towards Synthetic Phosphopeptide Substrates

1995 • 32 citations

Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes

1991 • 30 citations