Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes: a new role for homocysteine in liver fibrosis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Homocysteine and Cardiovascular Disease

1998 • 2,177 citations

Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population

1993 • 1,920 citations

Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis.

1969 • 1,846 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1993 • 1,330 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Disorders of transsulfuration

1989 • 1,053 citations

Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

1993 • 865 citations

Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis.

1994 • 812 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

1989 • 649 citations

The metabolism of homocysteine: pathways and regulation

1998 • 583 citations

Construction of DNA sequences complementary to rat .alpha.1 and .alpha.2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D

1984 • 568 citations

Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.

1984 • 414 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Hyperhomocysteinemia After an Oral Methionine Load Acutely Impairs Endothelial Function in Healthy Adults

1998 • 342 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

The EMBL data library.

1988 • 314 citations

Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B(-1)2, and vitamin B-6 status

1996 • 307 citations

Homocysteine as a Risk Factor for Vascular Disease

1997 • 269 citations

Acute methionine load‐induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage‐derived tissue factor activity in rats

1997 • 218 citations

Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis.

1997 • 211 citations

Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells.

1996 • 207 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

Elevated Plasma Homocysteine in Alcoholics

1993 • 189 citations

Altered Balance Between Matrix Metalloproteinases and Their Inhibitors in Experimental Biliary Fibrosis

1998 • 188 citations

The GenBank^®genetic sequence data bank

1988 • 187 citations

Synergistic Transcriptional Activation of the Tissue Inhibitor of Metalloproteinases-1 Promoter via Functional Interaction of AP-1 and Ets-1 Transcription Factors

1996 • 179 citations

Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation

1996 • 177 citations

Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43.

1993 • 175 citations

Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c‐fos and c‐myb in smooth muscle cells

1997 • 130 citations

Hepatocyte proliferation in primary biliary cirrhosis as assessed by proliferating cell nuclear antigen and Ki-67 antigen labelling

1995 • 127 citations

HOMOCYSTEINE AND VASCULAR DYSFUNCTION

1997 • 127 citations

Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells

1998 • 124 citations

Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes

1998 • 102 citations

The EMBL data library

1986 • 93 citations

Carbon tetrachloride–induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: Effect ofS-adenosylmethionine treatment

1995 • 89 citations

Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

1993 • 85 citations

Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease

1997 • 83 citations

Homocysteine stimulates the production and secretion of cholesterol in hepatic cells

1998 • 80 citations

TIMP expression in toxic and cholestatic liver injury in rat

1997 • 78 citations

Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter

1998 • 74 citations

Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis

1994 • 65 citations

Reduction-oxidation (redox) state regulation of extracellular matrix metalloproteinases and tissue inhibitors in cardiac normal and transformed fibroblast cells

1996 • 65 citations

Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis

1993 • 58 citations

Synthesis of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in human hepatoma cells (HepG2) Up‐regulation by interleukin‐6 and transforming growth factor β1

1992 • 56 citations

ERK2 Activation by Homocysteine in Vascular Smooth Muscle Cells

1998 • 55 citations

Altered processing of precursor transcripts and increased levels of the subunit I of mitochondrial cytochrome c oxidase in Syrian hamster fetal cells initiated with ionizing radiation

1997 • 11 citations