Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

1985 • 702 citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.

1989 • 579 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

1992 • 333 citations

Structure of the human type IV collagenase gene.

1990 • 310 citations

In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in nonparenchymal liver cells

1989 • 281 citations

Expression of platelet-derived growth factor and its receptors in normal human liver and during active hepatic fibrogenesis.

1996 • 279 citations

Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)

1991 • 278 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

The synthesis of proteoglycans in fat-storing cells of rat liver

1987 • 259 citations

Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver.

1994 • 253 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Cellular Sources of Noncollagenous Matrix Proteins: Role of Fat-Storing Cells in Fibrogenesis

1990 • 227 citations

Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2

1991 • 227 citations

Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths

1992 • 221 citations

The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver

1992 • 212 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2

1991 • 198 citations

Distribution of collagenase and tissue inhibitor of metalloproteinases (TIMP) in colorectal tumours

1991 • 192 citations

Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis

1990 • 192 citations

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

1989 • 177 citations

Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats

1995 • 167 citations

Distinct localization of collagenase and tissue inhibitor of metalloproteinases expression in wound healing associated with ulcerative pyogenic granuloma.

1992 • 167 citations

Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.

1994 • 162 citations

Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts.

1987 • 146 citations

Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver.

1990 • 144 citations

Increase in type I and type III collagens in human alcoholic liver cirrhosis.

1976 • 125 citations

The complex between a tissue inhibitor of metalloproteinases (TIMP‐2) and 72‐kDa progelatinase is a metalloproteinase inhibitor

1991 • 109 citations

Kupffer cell–derived 95-kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells

1995 • 109 citations

Identification of a serum- and phorbol ester-responsive element in the murine tissue inhibitor of metalloproteinase gene.

1991 • 98 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 97 citations

Human progelatinase A can be activated by matrilysin

1994 • 97 citations

Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver

1991 • 75 citations

Matrix Degradation in the Liver

1990 • 73 citations

Synthesis of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in human hepatoma cells (HepG2) Up‐regulation by interleukin‐6 and transforming growth factor β1

1992 • 56 citations

TIMP‐1 protein expression is stimulated by IL‐1β and IL‐6 in primary rat hepatocytes

1994 • 50 citations

Temporal and spatial patterns of proto-oncogene expression at early stages of toxic liver injury in the rat.

1991 • 49 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 23 citations

Large inhibitor of metalloproteinases (LIMP) contains tissue inhibitor of metalloproteinases (TIMP)-2 bound to 72,000-Mr progelatinase

1992 • 21 citations

Basal expression of the gene (TIMP) encoding the murine tissue inhibitor of metalloproteinases is mediated through AP1- and CCAAT-binding factors

1992 • 17 citations

Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization.

1992 • 6 citations