Cyclic AMP Regulation of Neutrophil Apoptosis Occurs via a Novel Protein Kinase A-independent Signaling Pathway

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

1991 • 1,017 citations

Epoxomicin, a potent and selective proteasome inhibitor, exhibitsin vivoantiinflammatory activity

1999 • 914 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

Granulocyte Apoptosis and Its Role in the Resolution and Control of Lung Inflammation

1999 • 526 citations

Molecular control of neutrophil apoptosis

2001 • 484 citations

Impairment of function in aging neutrophils is associated with apoptosis.

1993 • 467 citations

Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival

1998 • 349 citations

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral

1998 • 337 citations

MAPK/ERK Overrides the Apoptotic Signaling from Fas, TNF, and TRAIL Receptors

2001 • 337 citations

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.

1994 • 333 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

Glucocorticoids Promote Nonphlogistic Phagocytosis of Apoptotic Leukocytes

1999 • 292 citations

Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2

1992 • 284 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Granulocyte-Macrophage Colony-Stimulating Factor Delays Neutrophil Constitutive Apoptosis Through Phosphoinositide 3-Kinase and Extracellular Signal-Regulated Kinase Pathways

2000 • 262 citations

CYCLIC AMP SIGNALING AND GENE REGULATION

1998 • 257 citations

Lactacystin, a Specific Inhibitor of the Proteasome, Induces Apoptosis in Human Monoblast U937 Cells

1995 • 214 citations

Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation

1996 • 206 citations

Hypoxia prolongs neutrophil survival in vitro

1995 • 203 citations

Mitochondrial control of apoptosis: an overview

1999 • 201 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets

1999 • 168 citations

Differential Regulation of Raf-1 and B-Raf and Ras-Dependent Activation of Mitogen-Activated Protein Kinase by Cyclic AMP in PC12 Cells

1995 • 146 citations

Agents That Elevate cAMP Inhibit Human Neutrophil Apoptosis

1995 • 137 citations

Type I cAMP-dependent Protein Kinase Delays Apoptosis in Human Neutrophils at a Site Upstream of Caspase-3

1998 • 135 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells

1996 • 118 citations

Immunopharmacology of neutrophils

1994 • 111 citations

The neutrophil

1989 • 104 citations

Regulation of eosinophil and neutrophil apoptosis – similarities and differences

2001 • 96 citations

Dexamethasone-induced suppression of apoptosis in human neutrophils requires continuous stimulation of new protein synthesis

1997 • 93 citations

TO‐PRO‐3 iodide: A novel HeNe laser‐excitable DNA stain as an alternative for propidium iodide in multiparameter flow cytometry

1994 • 92 citations

Adenosine 3′,5′-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

2001 • 75 citations

Temperature-dependent Arrest of Neutrophil Apoptosis

2000 • 74 citations

Coupling of neutrophil apoptosis to recognition by macrophages: coordinated acceleration by protein synthesis inhibitors

1997 • 64 citations

Prostaglandin E2 inhibits apoptosis in human neutrophilic polymorphonuclear leukocytes: role of intracellular cyclic AMP levels.

1998 • 63 citations

Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.

1995 • 34 citations

Cyclic AMP Inhibits PDGF-stimulated Mitogen-activated Protein Kinase Activity in Rat Aortic Smooth Muscle Cells via Inactivation of c-Raf-1 Kinase and Induction of MAP Kinase Phosphatase-1

1997 • 28 citations

Tyrosine Kinase and Phosphatidylinositol 3-Kinase Activation Are Required for Cyclic Adenosine 3′,5′-Monophosphate-Dependent Potentiation of Deoxyribonucleic Acid Synthesis Induced by Insulin-Like Growth Factor-I in FRTL-5 Cells

2000 • 27 citations

Inflammation, Cell Injury, and Apoptosis

2020 • 18 citations