Prostaglandin D synthase: Structure and function

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.

1994 • 1,729 citations

The lipocalin protein family: structure and function

1996 • 1,658 citations

Activation of Ventrolateral Preoptic Neurons During Sleep

1996 • 1,077 citations

The structure of β-lactoglobulin and its similarity to plasma retinol-binding protein

1986 • 870 citations

Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein

1998 • 733 citations

Bovine β-lactoglobulin at 1.8 Å resolution — still an enigmatic lipocalin

1997 • 677 citations

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

1982 • 588 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Increased Production of Prostaglandin D2 in Patients with Systemic Mastocytosis

1980 • 430 citations

The three-dimensional structure of retinol-binding protein.

1984 • 404 citations

Molecular mechanisms of diverse actions of prostanoid receptors

1995 • 390 citations

Pheromone binding to two rodent urinary proteins revealed by X-ray crystallography

1992 • 368 citations

Fertility-Associated Proteins in Holstein Bull Seminal Plasma1

1993 • 361 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Crystal structure of the trigonal form of bovine beta-lactoglobulin and of its complex with retinol at 2.5 Å resolution

1987 • 336 citations

Molecular Cloning and Characterization of the Human Prostanoid DP Receptor

1995 • 332 citations

Crystallographic refinement of human serum retinol binding protein at 2Å resolution

1990 • 310 citations

β-Lactoglobulin Binds Palmitate within Its Central Cavity

1999 • 298 citations

Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase

1997 • 263 citations

Prostaglandin D2 formation and characterization of its synthetases in various tissues of adult rats

1988 • 258 citations

Endogenous sleep-promoting substances and sleep regulation

1989 • 256 citations

Homology and structure‐function correlations between α ₁ ‐acid glycoprotein and serum retinol‐binding protein and its relatives

1987 • 252 citations

Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D ₂ and E ₂

1991 • 242 citations

Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.

1993 • 239 citations

Purification and characterization of rat brain prostaglandin D synthetase.

1985 • 239 citations

Proteins in Normal Cerebrospinal Fluid Not Found in Serum.

1961 • 227 citations

Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene.

1994 • 226 citations

Prostaglandin D2, a cerebral sleep-inducing substance in monkeys.

1988 • 225 citations

The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues.

1989 • 221 citations

Domain swapping creates a third putative combining site in bovine odorant binding protein dimer

1996 • 215 citations

Lipocalin-type Prostaglandin D Synthase (β-Trace) Is a Newly Recognized Type of Retinoid Transporter

1997 • 209 citations

The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition

1996 • 208 citations

The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution.

1987 • 199 citations

Biological activities and mechanisms of action of PGJ2 and related compounds: an update

1992 • 188 citations

Purification and Chemical Characterization of β‐Trace Protein from Human Cerebrospinal Fluid: Its Identification as Prostaglandin D Synthase

1993 • 186 citations

Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins.

1991 • 184 citations

Nociceptive effects induced by intrathecal administration of prostaglandin D2, E2, or F2α to conscious mice

1990 • 178 citations

Role of prostaglandin D2 in the hypothermia of rats caused by bacterial lipopolysaccharide.

1982 • 177 citations

The biology and pharmacology of PGD2

1988 • 174 citations

Identification of a Fertility-Associated Protein in Bull Seminal Plasma As Lipocalin-Type Prostaglandin D Synthase1

1998 • 171 citations

Purification and characterisation of prostaglandin endoperoxide D-isomerase, a cytoplasmic, glutathione-requiring enzymE

1979 • 168 citations

Prostaglandin D2 and sleep regulation

1999 • 162 citations

Crystallization, crystal structure analysis and preliminary molecular model of the bilin binding protein from the insect Pieris brassicae

1987 • 162 citations

Promotion of sleep mediated by the A2a-adenosine receptor and possible involvement of this receptor in the sleep induced by prostaglandin D2 in rats.

1996 • 162 citations

Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D ₂

1998 • 161 citations

Expression of lipocalin-type prostaglandin D synthase (β-trace) in human heart and its accumulation in the coronary circulation of angina patients

1997 • 160 citations

Sleep-wake regulation by prostaglandins D2 and E2.

1988 • 157 citations

Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog.

1988 • 156 citations

Prostaglandin D2, a cerebral sleep-inducing substance in rats.

1983 • 154 citations

Crystal structures of a nitric oxide transport protein from a blood-sucking insect

1998 • 154 citations

Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.

1985 • 150 citations

c-Kit Ligand Mediates Increased Expression of Cytosolic Phospholipase A2, Prostaglandin Endoperoxide Synthase-1, and Hematopoietic Prostaglandin D2 Synthase and Increased IgE-dependent Prostaglandin D2 Generation in Immature Mouse Mast Cells

1995 • 149 citations

Occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin D2 in human urine.

1988 • 149 citations

Characterization of rat spleen prostaglandin H <scp>d</scp>-isomerase as a sigma-class GSH transferase

1995 • 149 citations

Prostanoid receptors and their biological actions

1993 • 147 citations

Effects of Neonatal Hypothyroidism on Rat Brain Gene Expression

1991 • 144 citations

Identification of β-Trace as Prostaglandin D Synthase

1994 • 142 citations

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

1994 • 142 citations

Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans.

1985 • 136 citations

Prostaglandin D2: A biochemical perspective

1989 • 133 citations

Biochemical and immunological characterization of rat spleen prostaglandin D synthetase.

1987 • 133 citations

The Structure of the Monomeric Porcine Odorant Binding Protein Sheds Light on the Domain Swapping Mechanism

1998 • 132 citations

Molecular characterization of β-trace protein in human serum and urine: a potential diagnostic marker for renal diseases

1997 • 131 citations

Purification and properties of prostaglandin D synthetase from rat brain.

1979 • 126 citations

Binding of Biliverdin, Bilirubin, and Thyroid Hormones to Lipocalin-Type Prostaglandin D Synthase

1999 • 125 citations

Mast cells contain spleen-type prostaglandin D synthetase.

1990 • 120 citations

The somnogenic T lymphocyte suppressor prostaglandin D2 is selectively elevated in cerebrospinal fluid of advanced sleeping sickness patients

1990 • 115 citations

Multiple molecular recognition properties of the lipocalin protein family

1995 • 114 citations

CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats

1997 • 112 citations

Prostaglandin D, E, and F synthases

1995 • 111 citations

Comparison of prostanoid forming capacity of neuronal and astroglial cells in primary cultures

1985 • 109 citations

Involvement of adenosine A2A receptor in sleep promotion

1998 • 105 citations

Lipocalin-Type Prostaglandin D Synthase in Human Male Reproductive Organs and Seminal Plasma1

1998 • 105 citations

The crystal structure of nitrophorin 4 at 1.5 å resolution: transport of nitric oxide by a lipocalin-based heme protein

1998 • 104 citations

Biochemical and immunological demonstration of prostaglandin D2, E2, and F2α formation from prostaglandin H2 by various rat glutathione S-transferase isozymes

1988 • 100 citations

Different responsiveness of prostaglandin D₂‐sensitive systems to prostaglandin D₂ and its analogues

1985 • 96 citations

Primary Structure of Rat Brain Prostaglandin D Synthetase Deduced from cDNA Sequence

1989 • 91 citations

IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2.

1995 • 87 citations

Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase.

1991 • 85 citations

Choroid plexus: the major site of mRNA expression for the β-trace protein (prostaglandin D synthase) in human brain

1996 • 83 citations

Carbohydrate Structures of β‐Trace Protein from Human Cerebrospinal Fluid: Evidence for “Brain‐Type”N‐Glycosylation

1994 • 83 citations

Crystal structure of liganded and unliganded forms of bovine plasma retinol-binding protein

1993 • 83 citations

Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain.

1987 • 82 citations

Lipocalin-Type Prostaglandin D Synthase (β-Trace) Is Located in Pigment Epithelial Cells of Rat Retina and Accumulates within Interphotoreceptor Matrix

1996 • 82 citations

Probing the Molecular Basis of Allergy

1999 • 82 citations

Plasmodium falciparum Produces Prostaglandins that are Pyrogenic, Somnogenic, and Immunosuppressive Substances in Humans

1998 • 81 citations

Structural and Functional Significance of Cysteine Residues of Glutathione-independent Prostaglandin D Synthase

1995 • 80 citations

Multiple control of fever production in the central nervous system of rabbits.

1988 • 80 citations

Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process.

1997 • 79 citations

Are cerebral prostanoids of astroglial origin? Studies on the prostanoid forming system in developing rat brain and primary cultures of rat astrocytes

1987 • 79 citations

Use of an Antiserum Against Cerebrospinal Fluid in Demonstration of Trace Proteins in Biological Fluids.

1962 • 79 citations

Cultured Leptomeningeal Cells Secrete Cerebrospinal Fluid Proteins

1996 • 75 citations

Immunological comparison of some proteins found in cerebrospinal fluid, urine and extracts from brain and kidney

1964 • 74 citations

Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds

1991 • 74 citations

Structural organization of the gene for prostaglandin D synthase in the rat brain.

1992 • 73 citations

Prostaglandin D Synthase (β-Trace) in Human Arachnoid and Meningioma Cells: Roles as a Cell Marker or in Cerebrospinal Fluid Absorption, Tumorigenesis, and Calcification Process

1997 • 73 citations

Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase

1998 • 69 citations

Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids

1996 • 69 citations

cDNA Cloning, Expression, and Mutagenesis Study of Liver-type Prostaglandin F Synthase

1999 • 67 citations

II. Isozyme specificity of rat liver glutathione S-transferases in the formation of PGF2α and PGE2 from PGH2

1987 • 66 citations

Protein synthesis at the blood-brain barrier. The major protein secreted by amphibian choroid plexus is a lipocalin

1992 • 65 citations

Eicosanoids are produced by microglia, not by astrocytes, in rat glial cell cultures

1995 • 64 citations

SUPPRESSIVE EFFECT OF PROSTAGLANDIN (PG)D₂ON PULSATILE LUTEINIZING HORMONE RELEASE IN CONSCIOUS CASTRATED RATS

1982 • 64 citations

Alterations in nociception after intracisternal administration of prostaglandin D2, E2 or F2α to conscious mice

1986 • 64 citations

β‐Trace protein in cerebrospinal fluid: A blood–CSF barrier–related evaluation in neurological diseases

1998 • 64 citations

Comparative Mapping of Lipocalin Genes in Human and Mouse: The Four Genes for Complement C8 γ Chain, Prostaglandin-d-Synthase, Oncogene-24P3, and Progestagen-Associated Endometrial Protein Map to HSA9 and MMU2

1994 • 63 citations

Expression of messenger RNA for the prostaglandin D receptor in the leptomeninges of the mouse brain

1997 • 63 citations

Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.

1986 • 62 citations

Inhibition of nociceptin‐induced allodynia in conscious mice by prostaglandin D₂

1997 • 62 citations

The first lipocalin with enzymatic activity

1991 • 61 citations

Prostaglandin D ₂ Inhibits Inducible Nitric Oxide Synthase Expression in Rat Vascular Smooth Muscle Cells

1998 • 59 citations

Characterization and Distribution of Prostaglandin D Synthetase in Rat Skin

1988 • 57 citations

Developmental expression of murine β-trace in embryos and adult animals suggests a function in maturation and maintenance of blood-tissue barriers

1996 • 57 citations

Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats

1994 • 55 citations

Beta-trace protein concentration in cerebrospinal fluid is decreased in patients with bacterial meningitis

1998 • 54 citations

Structure and chromosomal localization of the human gene for a brain form of prostaglandin D2 synthase

1992 • 54 citations

Trace Proteins in Biological Fluids. IV. Physicochemical Properties and Sites of Formation of -Trace and -Trace Proteins.

1967 • 53 citations

Dominant Expression of Rat Prostanoid DP Receptor mRNA in Leptomeninges, Inner Segments of Photoreceptor Cells, Iris Epithelium, and Ciliary Processes

1998 • 52 citations

Rat Prostaglandin D2 Synthetase: Its Tissue Distribution, Changes during Maturation, and Regulation in the Testis and Epididymis1

1998 • 52 citations

Prostaglandin D Synthase Concentration in Cerebrospinal Fluid and Serum of Patients with Neurological Disorders

1997 • 51 citations

METABOLIC STUDIES ON ¹²⁵I‐LABELLED BETA‐TRACE PROTEIN, WITH SPECIAL REFERENCE TO SYNTHESIS WITHIN THE CENTRAL NERVOUS SYSTEM

1973 • 50 citations

Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.

1996 • 49 citations

Glutathione-independent prostaglandin D synthase as a lead molecule for designing new functional proteins

1996 • 48 citations

Glutathione-Independent Prostaglandin D2 Synthase in Ram and Stallion Epididymal Fluids: Origin and Regulation1

1999 • 47 citations

Three‐dimensional structure and active site of three hydrophobic molecule‐binding proteins with significant amino acid sequence similarity

1992 • 47 citations

Purification and N-terminal sequence of β-trace, a protein abundant in human cerebrospinal fluid

1993 • 47 citations

BETA-TRACE PROTEIN CONCENTRATION IN CSF IN NEUROLOGICAL DISORDERS

1972 • 46 citations

Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system

1987 • 46 citations

Quantification of prostaglandin D synthetase in cerebrospinal fluid: A potential marker for brain tumor

1998 • 46 citations

Prostaglandins and sleep

1995 • 45 citations

X-ray crystallographic identification of a protein-binding site for both all-trans- and 9-cis-retinoic acid.

1993 • 44 citations

Purification and characterization of prostaglandin F synthase from bovine liver

1992 • 44 citations

Prostaglandin D Synthase in Human Megakaryoblastic Cells

1997 • 43 citations

Molecular mechanism of sleep regulation by prostaglandin D2

1996 • 42 citations

Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells.

1995 • 41 citations

Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (β-trace) gene

1998 • 38 citations

Roles of Prostaglandins D₂ and E₂ in Interleukin‐1‐Induced Activation of Norepinephrine Turnover in the Brain and Peripheral Organs of Rats

1995 • 37 citations

Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids.

1998 • 37 citations

β-Trace Gene Expression Is Regulated by a Core Promoter and a Distal Thyroid Hormone Response Element

1997 • 37 citations

Hypothyroidism Alters the Expression of Prostaglandin D₂ Synthase/β‐ Trace in Specific Areas of the Developing Rat Brain

1997 • 37 citations

Brain-type prostaglandin D synthetase occurs in the rat cochlea.

1987 • 35 citations

CORRELATION BETWEEN THE CONCENTRATION OF -TRACE PROTEIN AND THE NUMBER OF SPERMATOZOA IN HUMAN SEMEN

1975 • 34 citations

Isolation and amino terminal sequence of β-trace, a novel protein from human cerebrospinal fluid

1991 • 34 citations

Acute and transient increase of lipocalin-type prostaglandin D synthase (β-trace) level in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage

1999 • 33 citations

Brain-Specific Prostaglandin D2 Synthetase mRNA Is Dependent on Thyroid Hormone during Rat Brain Development

1993 • 33 citations

Neuronal and glial prostaglandin D synthase isozymes in chick dorsal root ganglia: a light and electron microscopic immunocytochemical study

1995 • 33 citations

Astrocytes synthesize and secrete prostaglandin D synthetase in vitro

1996 • 31 citations

Trace proteins in cerebrospinal fluid and other biological fluids I. Effect of various fractionation procedures on β-trace and γ-trace proteins and methods for isolation of both proteins

1963 • 30 citations

Muramyl dipeptide-elicited production of PGD2 from astrocytes in culture

1988 • 30 citations

Quantitative Sandwich Enzyme-linked Immunosorbent Assay for Human Secretory Prostaglandin D Synthase (.BETA.-Trace).

1996 • 28 citations

9 alpha,11 beta-prostaglandin F2 formation in various bovine tissues. Different isozymes of prostaglandin D2 11-ketoreductase, contribution of prostaglandin F synthetase and its cellular localization.

1990 • 27 citations

IMMUNOCHEMICAL AND IMMUNOFLUORESCENCE STUDIES OF BETA‐TRACE PROTEIN IN DIFFERENT SPECIES AND ORGANS, WITH SPECIAL REFERENCE TO THE CENTRAL NERVOUS SYSTEM

1973 • 27 citations

Identification of a brain-specific human cerebrospinal fluid glycoprotein, beta-trace protein.

1993 • 26 citations

Analysis of low-molecular-mass proteins in cerebrospinal fluid by sodium dodecyl sulfate capillary gel electrophoresis

1997 • 25 citations

Induction of Hematopoietic Prostaglandin D Synthase in Human Megakaryocytic Cells by Phorbol Ester

1997 • 23 citations

Circadian Variations of Prostaglandins D2, E2, and F2α in the Cerebrospinal Fluid of Anesthetized Rats

1995 • 23 citations

DISTRIBUTION OF SERUM PROTEINS AND BETA‐TRACE PROTEIN WITHIN THE NERVOUS SYSTEM

1973 • 22 citations

Sodium dodecyl sulfate–capillary gel electrophoretic analysis of molecular mass microheterogeneity of β-trace protein in cerebrospinal fluid from patients with central nervous system diseases

1998 • 21 citations

Prostaglandin D synthase is the key enzyme in the promotion of physiological sleep.

1993 • 20 citations

The lipocalin XLCpl1 expressed in the neural plate of Xenopus laevis embryos is a secreted retinaldehyde binding protein

1996 • 20 citations

Constitutive secretion of β-trace protein by cultivated porcine choroid plexus epithelial cells: Elucidation of its complete amino acid and cDNA sequences

1996 • 19 citations

Expression of bovine lung prostaglandin F synthase in Escherichia coli

1991 • 17 citations

Prostaglandin D2 synthase: a component of human amniotic fluid and its association with fetal abnormalities

1996 • 17 citations

Inhibition of brain prostaglandin d synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids

1983 • 16 citations

Functionally diverse purinergic P2Y-receptors mediate prostanoid synthesis in cultured rat astrocytes: the role of ATP-induced phosphatidyl-inositol breakdown.

1992 • 12 citations

Isolation and partial characterization of "trace" proteins and immunoglobulin G from cerebrospinal fluid.

1965 • 12 citations

Biosynthesis of prostaglandin D2 by motoneurons and dorsal horn microneurons: A biochemical and high resolution immunocytochemical study in chick spinal cord

1995 • 11 citations

Prostaglandin-D-synthase (β-trace protein) levels in rat cerebrospinal fluid

1998 • 10 citations

Demonstration of synthesis of beta-trace protein in different tissues of squirrel monkey.

1975 • 9 citations

Different Effects of Prostaglandin E₁, E₂ and D₂ on Pancreatic Somatostatin Release

2008 • 6 citations

Immunodetection of prostaglandin D synthase: conditions of localization in a defined subclass of primary sensory neurons.

1995 • 5 citations

EVIDENCE OF PROSTAGLANDIN PRODUCTION BY THE HUMAN MALARIA PARASITE, PLASMODIUM FALCIPARUM

1998 • 3 citations