Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism

Immunol. Cell Biol.

1995 • 2,564 citations

Cancer statistics, 1998

1998 • 2,407 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer.

1994 • 467 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Clinical Trials: IL-12 Deaths: Explanation and a Puzzle

1995 • 333 citations

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.

1996 • 248 citations

IL-12: a key cytokine in immune regulation

1996 • 236 citations

Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.

1992 • 232 citations

TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma

1983 • 223 citations

Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides.

1993 • 213 citations

Systemic administration of rIL-12 induces complete tumor regression and protective immunity: response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells

1995 • 202 citations

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

1996 • 193 citations

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

1999 • 192 citations

Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.

1992 • 187 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Amount of interleukin 12 available at the tumor site is critical for tumor regression.

1996 • 177 citations

HER-2/neu Protein: A Target for Antigen-Specific Immunotherapy of Human Cancer

1997 • 173 citations

Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

1995 • 172 citations

Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.

1994 • 167 citations

A nonimmunogenic sarcoma transduced with the cDNA for interferon gamma elicits CD8+ T cells against the wild-type tumor: correlation with antigen presentation capability.

1992 • 159 citations

Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer.

1997 • 150 citations

Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.

1999 • 141 citations

Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.

1995 • 138 citations

IL-12 regulates VEGF and MMPs in a murine breast cancer model

1998 • 138 citations

CD4 T cells inhibit in vivo the CD8‐mediated immune response against murine colon carcinoma cells transduced with interleukin‐12 genes

1995 • 125 citations

Cytokine Gene Therapy of Cancer Using Gene Gun Technology: Superior Antitumor Activity of Interleukin-12

1997 • 118 citations

Primary proliferative T cell response to wild‐type p53 protein in patients with breast cancer

1995 • 98 citations

The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity.

1994 • 85 citations

Gene Gun-Mediated IL-12 Gene Therapy Induces Antitumor Effects in the Absence of Toxicity: A Direct Comparison With Systemic IL-12 Protein Therapy

1999 • 81 citations

The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.

1997 • 69 citations

Human tumour antigens recognized by T cells: new perspectives for anti-cancer vaccines?

1997 • 55 citations

Cancer Trial of Interleukin-12 Halted

1995 • 51 citations

Breast cancer immunotherapy: Current status and future prospects

1996 • 48 citations

Human tumor antigens recognized by T lymphocytes: implications for cancer therapy

1996 • 47 citations

Interleukin-12: potential role in cancer therapy.

1995 • 38 citations

Cytokine gene-modified vaccines in the therapy of cancer

1996 • 33 citations

Alloantigen-activated lymphocytes from mice bearing a spontaneous "nonimmunogenic" adenocarcinoma inhibit its growth in vivo by recruiting host immunoreactivity.

1985 • 26 citations

IL-12 anticancer gene therapy: magic bullets from a golden gun

1996 • 24 citations

Tumor transplantation and tumor immunity: a personal view.

1991 • 21 citations

Administration of Recombinant Interleukin 12 Prevents Outgrowth of Tumor Cells Metastasizing Spontaneously to Lung and Lymph Nodes

1997 • 17 citations

The Role of NK Cells in the Regulation of Experimental Metastasis in a Murine Lymphoma System

1991 • 8 citations