Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

Central nervous system control of food intake

2000 • 6,305 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome

2000 • 2,695 citations

Comparative distribution of estrogen receptor-? and -? mRNA in the rat central nervous system

1997 • 2,244 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Distribution of androgen and estrogen receptor mRNA‐containing cells in the rat brain: An in situ hybridization study

1990 • 2,107 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Increased adipose tissue in male and female estrogen receptor-α knockout mice

2000 • 1,226 citations

Signals That Regulate Food Intake and Energy Homeostasis

1998 • 1,190 citations

From Lesions to Leptin

1999 • 1,165 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Hypothalamic insulin signaling is required for inhibition of glucose production

2002 • 852 citations

Diabetes, Obesity, and the Brain

2005 • 840 citations

Immunolocalization of Estrogen Receptor β in the Mouse Brain: Comparison with Estrogen Receptor α

2003 • 818 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography

1986 • 548 citations

A Controlled High-Fat Diet Induces an Obese Syndrome in Rats

2003 • 526 citations

Unraveling the central nervous system pathways underlying responses to leptin

1998 • 520 citations

Direct effects of sex steroid hormones on adipose tissues and obesity

2004 • 492 citations

Increased Estrogen Production in Obese Men*

1979 • 489 citations

Estrogen increases in vivo leptin production in rats and human subjects

1997 • 482 citations

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

2003 • 458 citations

Gonadal effects on food intake and adiposity: A metabolic hypothesis

1979 • 444 citations

Quantitative study of insulin secretion and clearance in normal and obese subjects.

1988 • 438 citations

Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

1995 • 434 citations

Femtosecond time-resolved X-ray diffraction from laser-heated organic films

1997 • 434 citations

Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities

2003 • 427 citations

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

1986 • 416 citations

The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations

2002 • 416 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight

1999 • 398 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 382 citations

Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain

1998 • 380 citations

Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei

1998 • 376 citations

Is the Energy Homeostasis System Inherently Biased Toward Weight Gain?

2003 • 355 citations

Sexual dimorphism of age-related changes in whole-body fat distribution in the obese

1994 • 350 citations

The morphology and metabolism of intraabdominal adipose tissue in men

1992 • 334 citations

Food Intake and the Regulation of Body Weight

2000 • 331 citations

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

2003 • 327 citations

Localization and Characterization of Insulin Receptors in Rat Brain and Pituitary Gland Usingin VitroAutoradiography and Computerized Densitometry*

1987 • 319 citations

Cyclic Estradiol Treatment Normalizes Body Weight and Restores Physiological Patterns of Spontaneous Feeding and Sexual Receptivity in Ovariectomized Rats

2002 • 317 citations

Distribution of estrogen receptor α and β in the mouse central nervous system: In vivo autoradiographic and immunocytochemical analyses

2004 • 311 citations

Intranasal Insulin Reduces Body Fat in Men but not in Women

2004 • 270 citations

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

1996 • 257 citations

Distinct Physiologic and Neuronal Responses to Decreased Leptin and Mild Hyperleptinemia¹

1999 • 250 citations

Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in

1998 • 239 citations

Monitoring of stored and available fuel by the CNS: implications for obesity

2003 • 231 citations

Regulation of Jak Kinases by Intracellular Leptin Receptor Sequences

2002 • 228 citations

In Vivo and in Vitro ob Gene Expression and Leptin Secretion in Rat Adipocytes: Evidence for a Regional Specific Regulation by Sex Steroid Hormones

1999 • 220 citations

Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y

2001 • 208 citations

Obesity, diabetes and the central nervous system

1998 • 185 citations

Androgenic control of food intake and body weight in male rats.

1976 • 160 citations

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

2003 • 156 citations

Eating Elicited by Orexin-A, But Not Melanin-Concentrating Hormone, Is Opioid Mediated

2002 • 154 citations

Acute third ventricular administration of insulin decreases food intake in two paradigms

2002 • 148 citations

Relationship between serum sex hormones and glucose, insulin and lipid abnormalities in men with myocardial infarction.

1977 • 143 citations

Differential Expression and Regulation of Leptin Receptor Isoforms in the Rat Brain: Effects of Fasting and Oestrogen

1998 • 141 citations

The evaluation of insulin as a metabolic signal influencing behavior via the brain

1996 • 138 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 130 citations

Leptin: A Significant Indicator of Total Body Fat but Not of Visceral Fat and Insulin Insensitivity in African-American Women

1996 • 126 citations

Differential Expression of Estrogen Receptor &agr; and &bgr; Immunoreactivity by Oxytocin Neurons of Rat Paraventricular Nucleus

1997 • 124 citations

Serum leptin concentration, body composition, and gonadal hormones during puberty

1999 • 123 citations

Central implants of diluted estradiol: independent effects on ingestive and reproductive behaviors of ovariectomized rats

1989 • 122 citations

Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus

1998 • 108 citations

Identification of estrogen receptor-containing neurons projecting to the rat supraoptic nucleus

1997 • 96 citations

CNS Melanocortin System Involvement in the Regulation of Food Intake

2000 • 95 citations

Leptin and OB-R: Body weight regulation by a cytokine receptor

1996 • 95 citations

Intraventricular insulin and the level of maintained body weight in rats.

1995 • 95 citations

Identification of estrogen receptor in human adipose tissue and adipocytes.

1994 • 91 citations

Distribution of estrogen receptor beta mRNA-containing cells in ovariectomized and estrogen-treated female rat brain

2003 • 91 citations

Central vs. peripheral effects of estrogen on food intake and lipoprotein lipase activity in ovariectomized rats

1986 • 91 citations

The effects of gonadectomy on the sex differences in dietary self-selection patterns and carcass compositions of rats

1973 • 88 citations

Cyclical Variations in the Abundance of Leptin Receptors, but not in Circulating Leptin, Correlate with NPY Expression during the Oestrous Cycle

1999 • 73 citations

Relation of Steroid Hormones to Glucose Tolerance and Plasma Insulin Levels in Men: Importance of visceral adipose tissue

1995 • 72 citations

Insulin as an adiposity signal

2001 • 72 citations

Association of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese women

2002 • 71 citations

The Obesity in Bilateral Ovariectomized Rats Is Related to a Decrease in the Expression of Leptin Receptors in the Brain

2002 • 70 citations

Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake

2003 • 69 citations

Effects of ovariectomy and estradiol injections on food intake and body weight in rats with ventromedial hypothalamic lesions

1975 • 58 citations

Association of the mitochondrial DNA 15497G/A polymorphism with obesity in a middle-aged and elderly Japanese population

2003 • 55 citations

Effects of PVN lesions on the responsiveness of female rats to estradiol

1992 • 53 citations

Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European fat distribution study

1995 • 48 citations

Effects of Exogenous Gonadal Steroids on Leptin Homeostasis in Rats

1999 • 47 citations

Leptin receptor 5′untranslated regions in the rat: relative abundance, genomic organization and relation to putative response elements

2001 • 42 citations

Central implants of dilute estradiol enhance the satiety effect if CCK-8.

1996 • 41 citations

Neuroendocrine regulation of food intake and body weight

1980 • 40 citations

Reduced energy expenditure after ventromedial hypothalamic lesions in female rats

1984 • 37 citations

Hypothalamic implants of dilute estradiol fail to reduce feeding in ovariectomized rats

2002 • 36 citations

Central implants of dilute estradiol enhance the satiety effect if CCK-8.

1996 • 34 citations

Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII

2003 • 31 citations

Identification and Characterization of a Functionally Distinct Form of Human Estrogen Receptor β

2002 • 31 citations

Relations of body fat and fat distribution to the serum lipid, apolipoprotein and insulin concentrations of Samoan men and women.

1995 • 30 citations

Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance

1996 • 27 citations

Relationships of Resting Energy Expenditure with Body Fat Distribution and Abdominal Fatness in Japanese Population.

2003 • 21 citations

Ventromedial hypothalamic lesions abolish compensatory reduction in energy expenditure to weight loss

1990 • 12 citations