Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

Integrin Signaling

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Transmembrane crosstalk between the extracellular matrix and the cytoskeleton

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1996 • 1,900 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

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Molecular complexity and dynamics of cell-matrix adhesions

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Structure of an IκBα/NF-κB Complex

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Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

The Crystal Structure of the IκBα/NF-κB Complex Reveals Mechanisms of NF-κB Inactivation

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Integrin signalling and tyrosine phosphorylation: just the FAKs?

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The Molecular Architecture of Focal Adhesions

1995 • 479 citations

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Integrin-linked kinase (ILK) and its interactors

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Protein kinase C involvement in focal adhesion formation

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Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.

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Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations

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C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes

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The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells

1999 • 300 citations

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

1998 • 287 citations

Drosophila Integrin-Linked Kinase Is Required at Sites of Integrin Adhesion to Link the Cytoskeleton to the Plasma Membrane

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Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

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A New Focal Adhesion Protein That Interacts with Integrin-Linked Kinase and Regulates Cell Adhesion and Spreading

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Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.

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A Conserved LIM Protein That Affects Muscular Adherens Junction Integrity and Mechanosensory Function in Caenorhabditis elegans

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Integrin-linked Kinase (ILK) Binding to Paxillin LD1 Motif Regulates ILK Localization to Focal Adhesions

2001 • 208 citations

A Novel Integrin-Linked Kinase–Binding Protein, Affixin, Is Involved in the Early Stage of Cell–Substrate Interaction

2001 • 207 citations

Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell Adhesion

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The <scp>UNC-112</scp> Gene in Caenorhabditis elegansEncodes a Novel Component of Cell–Matrix Adhesion Structures Required for Integrin Localization in the Muscle Cell Membrane

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Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.

1996 • 188 citations

Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

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The integrin αvβ6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin

1998 • 153 citations

Parvin, a 42 kDa focal adhesion protein, related to the α-actinin superfamily

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Activated R-Ras, Rac1, Pi 3-Kinase and Pkcε Can Each Restore Cell Spreading Inhibited by Isolated Integrin β1 Cytoplasmic Domains

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A Critical Role of the PINCH-Integrin-linked Kinase Interaction in the Regulation of Cell Shape Change and Migration

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Integrin-linked kinase and PINCH: partners in regulation of cell-extracellular matrix interaction and signal transduction

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Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc

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Dissection of Pathways Implicated in Integrin-mediated Actin Cytoskeleton Assembly

1997 • 94 citations

Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations

1998 • 87 citations

Regulation of fibronectin matrix deposition and cell proliferation by the PINCH‐ILK‐CH‐ILKBP complex

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The Distribution and Regulation of Integrin-Linked Kinase in Normal and Diabetic Kidneys

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Solution Structure of the Focal Adhesion Adaptor PINCH LIM1 Domain and Characterization of Its Interaction with the Integrin-linked Kinase Ankyrin Repeat Domain

2001 • 78 citations

The Roles of Integrin-Linked Kinase in the Regulation of Myogenic Differentiation

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Requirement for diacylglycerol and protein kinase C in HeLa cell-substratum adhesion and their feedback amplification of arachidonic acid production for optimum cell spreading.

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Protein kinase C modulation of fibronectin matrix assembly.

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ILK interactions

2001 • 38 citations