Helicobacter pylori Urease Suppresses Bactericidal Activity of Peroxynitrite via Carbon Dioxide Production

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity.

1997 • 1,109 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Helicobacter pylori infection induces gastric cancer in Mongolian gerbils

1998 • 997 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

Inducible nitric oxide synthase: what difference does it make?

1997 • 964 citations

Helicobacter pylori and the Pathogenesis of Gastroduodenal Inflammation

1990 • 688 citations

“NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms

1996 • 660 citations

Dichlorodihydrofluorescein and Dihydrorhodamine 123 Are Sensitive Indicators of Peroxynitritein Vitro:Implications for Intracellular Measurement of Reactive Nitrogen and Oxygen Species

1997 • 616 citations

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

1995 • 506 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

Mechanisms of nitric oxide-related antimicrobial activity

1997 • 439 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils.

1998 • 412 citations

Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis☆, ☆☆

1999 • 408 citations

Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid

1990 • 400 citations

Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis

1996 • 339 citations

Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori

1994 • 333 citations

Reactive Nitrogen Species and Tyrosine Nitration in the Respiratory Tract

1999 • 308 citations

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

1996 • 277 citations

Kinetics of Peroxynitrite Reaction with Amino Acids and Human Serum Albumin

1999 • 253 citations

Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil.

1998 • 249 citations

Expression of Helicobacter pylori urease genes in Escherichia coli grown under nitrogen-limiting conditions

1992 • 232 citations

Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

1997 • 226 citations

Helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury

1992 • 197 citations

The Helicobacter pylori UreI Protein Is Not Involved in Urease Activity but Is Essential for Bacterial Survival In Vivo

1998 • 181 citations

Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite

1996 • 168 citations

Free Radicals in Viral Pathogenesis: Molecular Mechanisms Involving Superoxide and NO

1998 • 167 citations

What Role Does Helicobacter pylori Play in Gastric Cancer?

1997 • 166 citations

Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells

1993 • 158 citations

Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice

1997 • 154 citations

Experimental Infection of Mongolian Gerbils with Wild-Type and Mutant Helicobacter pylori Strains

1998 • 140 citations

CO₂-Catalyzed One-Electron Oxidations by Peroxynitrite: Properties of the Reactive Intermediate

1998 • 138 citations

Characterization of the Helicobacter pylori urease and purification of its subunits

1991 • 134 citations

Effect of nitric oxide on staphylococcal killing and interactive effect with superoxide

1996 • 117 citations

Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients.

1999 • 111 citations

Diffusion of Peroxynitrite in the Presence of Carbon Dioxide

1999 • 110 citations

Helicobacter pyloriGenerates Superoxide Radicals and Modulates Nitric Oxide Metabolism

1998 • 109 citations

Pathophysiology of Helicobacter pylori infection.

1994 • 107 citations

Urease Plays an Important Role in the Chemotactic Motility of Helicobacter pylori in a Viscous Environment

1998 • 107 citations

Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis

1993 • 103 citations

Possibility of chemoprevention by the eradication of Helicobacter pylori: oxidative DNA damage and apoptosis in H. pylori infection.

1997 • 97 citations

Activation of human phagocyte oxidative metabolism by Helicobacter pylori

1992 • 97 citations

Carbon Dioxide Modulation of Hydroxylation and Nitration of Phenol by Peroxynitrite

1997 • 95 citations

Quantitation of Protein-Bound 3-Nitrotyrosine and 3,4-Dihydroxyphenylalanine by High-Performance Liquid Chromatography with Electrochemical Array Detection

1997 • 88 citations

Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide

1993 • 76 citations

Pathophysiology ofHelicobacter pyloriInfection

1994 • 71 citations

Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobacter pylori infection in gastritis and gastric precancerous lesions in humans

1998 • 65 citations

[16] Measurement and significance of free and protein-bound 3-nitrotyrosine, 3-chlorotyrosine, and free 3-nitro-4-hydroxyphenylacetic acid in biologic samples: A high-performance liquid chromatography method using electrochemical detection

1999 • 65 citations

Toxicity of Peroxynitrite and Related Reactive Nitrogen Species toward Escherichia coli

1997 • 64 citations

Essential role of Helicobacter pylori urease in gastric colonization: definite proof using a urease-negative mutant constructed by gene replacement.

1994 • 56 citations

Modulatory Role of Nitric Oxide on Superoxide-Dependent Luminol Chemiluminescence

1996 • 55 citations

Highly Significant Role ofHelicobacter pyloriUrease in Phagocytosis and Production of Oxygen Metabolites by Human Granulocytes

1998 • 42 citations

Enhanced Expression of Inducible Nitric Oxide Synthase in Chronic Gastritis With Intestinal Metaplasia

1998 • 35 citations

The Mechanism of the Peroxynitrite–Carbon Dioxide Reaction Probed Using Tyrosine

1997 • 32 citations

Measurement of urea and ammonium concentrations in gastric juice.

1993 • 24 citations

Helicobacter pylori-human polymorphonuclear leucocyte interaction in the presence of ammonia

1997 • 12 citations

Modeling Transcriptional Regulation Using Microinjection intoXenopusOocytes

1999 • 11 citations